5LOF: Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1

PDB ID: 5LOFDownload
MMDB ID: 144416
PDB Deposition Date: 2016/8/9
Updated in MMDB: 2018/11
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 5LOF: monomeric; determined by software (PISA)
Molecular Components in 5LOF
Label Count Molecule
Protein (1 molecule)
1
Maltose-binding Periplasmic Protein,induced Myeloid Leukemia Cell Differentiation Protein Mcl-1
(Gene symbol: malE)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303