6ALE: A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model

PDB ID: 6ALEDownload
MMDB ID: 165416
PDB Deposition Date: 2017/8/7
Updated in MMDB: 2018/08
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 6ALE: dimeric; determined by author and by software (PISA)
Molecular Components in 6ALE
Label Count Molecule
Proteins (2 molecules)
1
Small Conductance Calcium-activated Potassium Channel Protein 2
Molecule annotation
1
Calmodulin-2
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
SULFATE IONSULFATE ION
2
1
(3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one(3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one
3
1
GLYCEROLGLYCEROL
4
2
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303