6H9B: 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

PDB ID: 6H9BDownload
MMDB ID: 169856
PDB Deposition Date: 2018/8/3
Updated in MMDB: 2018/12
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 6H9B: pentameric; determined by author and by software (PISA)
Molecular Components in 6H9B
Label Count Molecule
Proteins (5 molecules)
2
Tubulin Alpha Chain
Molecule annotation
2
Tubulin Beta Chain
Molecule annotation
1
Stathmin-4
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
11
SULFATE IONSULFATE ION
2
2
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
3
2
MAGNESIUM IONMAGNESIUM ION
4
2
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
5
2
9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303