National Center for
Biotechnology Information

6PB0: Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35

PDB ID:

MMDB ID:

184095

PDB Deposition Date:

2019/6/12

Updated in MMDB:

2024/10

Experimental Method:

electron microscopy

Resolution:

3 Å

Source Organism:

synthetic construct▼

Taxonomy	Molecule
synthetic construct	N
Homo sapiens	R, U, A, B, G

Similar Structures:

Biological Unit for 6PB0: hexameric; determined by author

Molecular Components in 6PB0
Label	Count	Molecule
Proteins (6 molecules)
R	1	Corticotropin-releasing Factor Receptor 1
U	1	Urocortin
A	1	Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short,guanine Nucleotide-binding Protein G(i) Subunit Alpha-1,guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
B	1	Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
G	1	Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
N	1	Nanobody 35
Chemicals and Non-standard biopolymers (12 molecules)
1	5	CHOLESTEROL
2	7	PALMITIC ACID

* Click molecule labels to explore molecular sequence information.

Citing MMDB