6QGV: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)

PDB ID: 6QGVDownload
MMDB ID: 183867
PDB Deposition Date: 2019/1/13
Updated in MMDB: 2020/02
Experimental Method:
x-ray diffraction
Resolution: 1.4  Å
Source Organism:
Similar Structures:
Biological Unit for 6QGV: monomeric; determined by author and by software (PISA)
Molecular Components in 6QGV
Label Count Molecule
Protein (1 molecule)
1
EGL Nine Homolog 1
(Gene symbol: EGLN1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
MANGANESE (II) IONMANGANESE (II) ION
2
1
8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione
3
1
GLYCEROLGLYCEROL
4
1
ISOPROPYL ALCOHOLISOPROPYL ALCOHOL
5
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303