6S8L: Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes

PDB ID: 6S8LDownload
MMDB ID: 181799
PDB Deposition Date: 2019
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.801  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 6S8L: trimeric; determined by author and by software (PISA)
Molecular Components in 6S8L
Label Count Molecule
Proteins (3 molecules)
1
Tubulin Alpha-1b Chain
Molecule annotation
1
Tubulin Beta-3 Chain
Molecule annotation
1
Designed Ankyrin Repeat Protein (Darpin) D1
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione
4
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303