6XBM: Structure of human SMO-Gi complex with 24(S),25-EC

PDB ID: 6XBMDownload
MMDB ID: 193459
PDB Deposition Date: 2020/6/6
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.14  Å
Source Organism:
Mus musculus
Similar Structures:
Biological Unit for 6XBM: pentameric; determined by author
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6XBM: Structure of human SMO-Gi complex with 24(S),25-EC
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Interactions?
RR: Smoothened homologAA: Guanine nucleotide-binding protein G(i) subunit alpha-1BB: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1GG: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2SS: scFv161CO1: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL1CO1: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL
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Molecular Components in 6XBM
Label Count Molecule
Proteins (5 molecules)
1
Smoothened Homolog
1 Protein
SS Diagram
1125250375500625652652 residues, click to see VAST similar structures.helix 224-253helix 266-282helix 313-345helix 357-378helix 398-428helix 439-476helix 477-494helix 516-533strand 197-200strand 212-215strand 294-297strand 299-302strand 380-385strand 388-393
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
1 Protein
SS Diagram
3D Domains
1125250354354 residues, click to see VAST similar structures.helix 7-31helix 46-53helix 242-255helix 296-309helix 330-351strand 33-41strand 184-192strand 193-201strand 219-227strand 262-270strand 317-324Domain 1 (33-354): click to see VAST similar structures1
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
1 Protein
SS Diagram
3D Domains
1125250344344 residues, click to see VAST similar structures.helix 9-29strand 50-56strand 60-68strand 72-80strand 81-89strand 90-99strand 105-110strand 114-120strand 124-130strand 137-144strand 148-157strand 159-167strand 168-176strand 177-185strand 190-197strand 201-208strand 210-217strand 221-227strand 232-239strand 243-250strand 252-259strand 262-269strand 276-283strand 288-294strand 296-302strand 307-313strand 318-325strand 330-336strand 338-344Domain 1 (40-187): click to see VAST similar structures1Domain 2 (188-315): click to see VAST similar structures2Domain 1 (316-344): click to see VAST similar structures1
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
1 Protein
SS Diagram
17171 residues, click to see VAST similar structures.helix 12-22helix 30-44
1
Scfv16
1 Protein
SS Diagram
3D Domains
1125259259 residues, click to see VAST similar structures.strand 2-8strand 9-13strand 16-26strand 32-40strand 45-53strand 57-61strand 67-75strand 76-85strand 91-100strand 114-119strand 138-142strand 145-149strand 151-163strand 165-168strand 170-180strand 185-191strand 193-196strand 202-209strand 210-220strand 224-232strand 242-246Domain 1 (1-128): click to see VAST similar structures1Domain 2 (129-259): click to see VAST similar structures2
Chemicals and Non-standard biopolymers (2 molecules)
2
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