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6XBM:
Structure of human SMO-Gi complex with 24(S),25-EC
PDB ID:
6XBM
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MMDB ID:
193459
PDB Deposition Date:
2020/6/6
Updated in MMDB:
2024/10
Experimental Method:
electron microscopy
Resolution:
3.14 Å
Source Organism:
Mus musculus
▼
Taxonomy
Molecule
Mus musculus
S
Homo sapiens
R, A, B, G
Similar Structures:
VAST+
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Biological Unit
Asymmetric Unit
Biological Unit for 6XBM: pentameric; determined by author
Molecular Graphic
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Interactions
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R
R: Smoothened homolog
A
A: Guanine nucleotide-binding protein G(i) subunit alpha-1
B
B: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
G
G: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
S
S: scFv16
1
CO1: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL
1
CO1: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL
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Protein
Nucleotide
Chemical
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Format:
ASN.1 (Cn3D)
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Data Set:
alpha-Carbons
Single 3D structure
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Molecular Components in 6XBM
Label
Count
Molecule
Proteins (5 molecules)
R
1
Smoothened Homolog
1 Protein
SS Diagram
1
125
250
375
500
625
652
652 residues, click to see VAST similar structures.
helix 224-253
helix 266-282
helix 313-345
helix 357-378
helix 398-428
helix 439-476
helix 477-494
helix 516-533
strand 197-200
strand 212-215
strand 294-297
strand 299-302
strand 380-385
strand 388-393
A
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
1 Protein
SS Diagram
3D Domains
1
125
250
354
354 residues, click to see VAST similar structures.
helix 7-31
helix 46-53
helix 242-255
helix 296-309
helix 330-351
strand 33-41
strand 184-192
strand 193-201
strand 219-227
strand 262-270
strand 317-324
Domain 1 (33-354): click to see VAST similar structures
1
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B
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
1 Protein
SS Diagram
3D Domains
1
125
250
344
344 residues, click to see VAST similar structures.
helix 9-29
strand 50-56
strand 60-68
strand 72-80
strand 81-89
strand 90-99
strand 105-110
strand 114-120
strand 124-130
strand 137-144
strand 148-157
strand 159-167
strand 168-176
strand 177-185
strand 190-197
strand 201-208
strand 210-217
strand 221-227
strand 232-239
strand 243-250
strand 252-259
strand 262-269
strand 276-283
strand 288-294
strand 296-302
strand 307-313
strand 318-325
strand 330-336
strand 338-344
Domain 1 (40-187): click to see VAST similar structures
1
Domain 2 (188-315): click to see VAST similar structures
2
Domain 1 (316-344): click to see VAST similar structures
1
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G
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
1 Protein
SS Diagram
1
71
71 residues, click to see VAST similar structures.
helix 12-22
helix 30-44
S
1
Scfv16
1 Protein
SS Diagram
3D Domains
1
125
259
259 residues, click to see VAST similar structures.
strand 2-8
strand 9-13
strand 16-26
strand 32-40
strand 45-53
strand 57-61
strand 67-75
strand 76-85
strand 91-100
strand 114-119
strand 138-142
strand 145-149
strand 151-163
strand 165-168
strand 170-180
strand 185-191
strand 193-196
strand 202-209
strand 210-220
strand 224-232
strand 242-246
Domain 1 (1-128): click to see VAST similar structures
1
Domain 2 (129-259): click to see VAST similar structures
2
click domain graphic to toggle highlight of corresponding residues in 3D viewer
Chemicals and Non-standard biopolymers (2 molecules)
1
2
17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303
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