8D80: Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3

PDB ID: 8D80Download
MMDB ID: 218234
PDB Deposition Date: 2022/6/7
Updated in MMDB: 2022/07
Experimental Method:
electron microscopy
Resolution: 3.6  Å
Source Organism:
Similar Structures:
Biological Unit for 8D80: trimeric; determined by author
Molecular Components in 8D80
Label Count Molecule
Proteins (3 molecules)
1
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
1
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
1
DNA-binding Protein Ikaros
(Gene symbol: IKZF1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
ZINC IONZINC ION
2
1
(3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione(3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303