8E9E: Rat protein farnesyltransferase in complex with FPP and inhibitor 2f

PDB ID: 8E9EDownload
MMDB ID: 222080
PDB Deposition Date: 2022/8/26
Updated in MMDB: 2022/11
Experimental Method:
x-ray diffraction
Resolution: 2.844  Å
Source Organism:
Similar Structures:
Biological Unit for 8E9E: dimeric; determined by author and by software (PISA)
Molecular Components in 8E9E
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha
(Gene symbol: Fnta)
Molecule annotation
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol: Fntb)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
4
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
2
9
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
4
1
ZINC IONZINC ION
5
1
(5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one(5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303