8RHT: Crystal Structure of Trypanosoma brucei DHFR in complex with the cofactor and inhibitor P25

PDB ID: 8RHTDownload
MMDB ID: 255217
PDB Deposition Date: 2023/12/17
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8RHT: monomeric; determined by author and by software (PISA)
Molecular Components in 8RHT
Label Count Molecule
Protein (1 molecule)
1
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303