8SZH: Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs

PDB ID: 8SZHDownload
MMDB ID: 242398
PDB Deposition Date: 2023/5/29
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8SZH: pentameric; determined by author
Molecular Components in 8SZH
Label Count Molecule
Proteins (5 molecules)
2
Extracellular Calcium-sensing Receptor
(Gene symbol: CASR)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-3
(Gene symbol: GNAI3)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
(Gene symbol: GNB1)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
(Gene symbol: GNG2)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
9
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amineN-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
3
2
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
4
4
CALCIUM IONCALCIUM ION
5
2
TRYPTOPHANTRYPTOPHAN
6
2
PHOSPHATE IONPHOSPHATE ION
7
4
SPERMINESPERMINE
8
1
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303