BioProject

SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. More...

SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have performed an expression profiling experiment of LNCaP cells either overexpressing SOX4 or GFP to identify SOX4 target genes. Keywords: Gene expression Overall design: LNCaP prostate cancer cells were transfected with either SOX4 or GFP expression vectors and total RNA harvested 24 hours post-transfection. Each transfection and RNA isolation was performed in triplicate and each hybridization was performed in duplicate providing 12 overall hybridizations on the Illumina platform. Less...