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5 additional projects are components of the Transcriptomic and Proteomic Effects of CDK8 and CDK19 Mediator Kinases.
RNA-Seq analysis was carried out to investigate the effects of expression of wild-type CDK8 (CDK8) or CDK19 (CDK19) or their kinase-inactive D173A mutants (CDK8M and CDK19M) in HEK293 cells (WT) and their CDK8/19 double-knockout (dKO) derivatives
Overall design: Two different sets of the re-expression derivatives of dKO cells generated with pHIV-dTomato or pHIV-luc-Blast based lentiviral constructs (dKO-V, dKO-8, dKO-8M, dKO-19 and dKO-19M; dKO-V_2, dKO-8_2, dKO-8M_2, dKO-19_2 and dKO-19M_2) and a set of the over-expression derivatives of WT cells generated with pHIV-luc-Blast based lentiviral constructs (WT-V, WT-8, WT-8M, WT-8M, WT-19 and WT-19M) were analyzed by RNA-Seq for transcriptomic profiles under regular culture condition. Each condition (expression derivative) was done in biological triplicate or more.
| Accession | PRJNA826484; GEO: GSE200753 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Chen M et al., "CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.", Nucleic Acids Res, 2023 Aug 11;51(14):7288-7313 |
| Submission | Registration date: 13-Apr-2022
College of Pharmacy, University of South Carolina |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 57 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 57 |
| GEO DataSets | 1 |