See
Genome Information for Candida albicans
To delineate the functional role of ZCF32 in Candida albicans biology, we carried out the genome wide expression analysis of wild-type and zcf32 null mutants by global expression array. We analysed the gene expression profiles of YPK102/1 and YPK102/2 and the parent wild type (SC5314) strain grown in YPD liquid medium at 30°C till the start of the stationary phase. In the microarray analysis, a total of 607 genes were found to be differentially expressed (fold change < 1.5 at p-value < 0.05) between the wild type and two zcf32 null mutants. Out of the 607 differentially expressed genes, 438 genes were up-regulated whereas 169 genes were down-regulated. Gene ontology (GO) analysis of up-regulated and down-regulated genes suggests that biofilm, filamentation, iron homeostasis, cell wall biogenesis, oxidation, and cell cycle are the major pathways altered in zcf32 null mutant.
Overall design: Organism : Candida albicans , Agilent Custom Candida albicans Gene Expression 8x15k Array (AMADID: 026377) designed by Genotypic Technology Private Limited.
| Accession | PRJNA306506; GEO: GSE76165 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Candida albicans[Taxonomy ID: 5476] Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade; Candida; Candida albicans |
| Publications | Kakade P et al., "ZCF32, a fungus specific Zn(II)2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans.", Sci Rep, 2016 Aug 8;6:31124 |
| Submission | Registration date: 18-Dec-2015
Genotypic Technology |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 24808 |
| Data volume, Processed Mbytes | 1 |
| Data volume, Supplementary Mbytes | 12 |