BioProject

Class 1 integrons are genetic elements that have played a major role in the global dissemination of antibiotic resistance. More...

Class 1 integrons are genetic elements that have played a major role in the global dissemination of antibiotic resistance. This study aimed to close gaps in the current model for the evolution of class 1 integrons, now widely found in pathogens in clinical settings. In particular, we wanted to reconstruct how one variant of the class 1 integrons from environmental settings made its way into the human microbiota. Specifically, we wanted to identify bacterial hosts that might have facilitated this transition, understand the order of assembly of the diverse elements that form the typical integron from clinical contexts, and establish the potential selective forces that fixed the integron in human commensal flora. Less...