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Accession: PRJNA1010464 ID: 1010464

Distinct Transcriptional Landscapes Identified by Radiographic Response in Metastatic Triple-Negative Breast Cancer Treated with Carboplatin, Nab-Paclitaxel, and Pembrolizumab in a Single-Arm Phase II Trial (human)

See Genome Information for Homo sapiens
A single arm, Phase II trial of carboplatin, nab-paclitaxel, and pembrolizumab (CNP) in metastatic triple negative breast cancer (mTNBC) was designed to evaluate overall response rate (ORR), progression-free survival (PFS), duration of response (DOR), safety/tolerability, and identify pathologic and transcriptomic correlates of response to therapy. More...
AccessionPRJNA1010464; GEO: GSE241876
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsWilkerson AD et al., "Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer.", Clin Cancer Res, 2024 Jan 5;30(1):82-93
SubmissionRegistration date: 29-Aug-2023
CLEVELAND CLINIC LERNER COM-CWRU
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments19
Publications
PubMed1
PMC1
Other datasets
BioSample19
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes6
SRA Data Details
ParameterValue
Data volume, Gbases342
Data volume, Tbytes0.11

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