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Metagenome-Assembled Genome: DRR221363_bin.37_MetaWRAP_v1.3_MAG

Identifiers
BioSample: SAMEA114096467; SRA: ERS16080308
Organism
uncultured Ruminococcus sp.
cellular organisms; Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae; Ruminococcus; environmental samples
Attributes
broad-scale environmental contextHuman digestive system
collection date2018
environmental mediumfaeces
geographic locationChina
investigation typemetagenome-assembled genome
isolation sourcehuman feces metagenome
project nameDiabetic peripheral neuropathy (DPN) is one of the serious and long-term complications of diabetes mellitus, which has no modifiable treatment. Here we reported the results of using fecal microbiota transplantation (FMT) from the healthy donors as a therapeutic alternative for patients with DPN. Compared to the patients received placebo, the patients with FMT via mid-gut showed significant alleviation of the function of sensory and motor nerves after 12 weeks, accompanying with improvement of the gut barrier integrity and decrease of proinflammatory cytokines. The metagenomic sequencing data suggested that the gut microbiota in patients after FMT had higher capacity to produce butyrate and decreased the biosynthesis of endotoxin. Thus, our work provides the feasibility of using FMT to treatment for DPN.
sample nameDRR221363_bin.37_MetaWRAP_v1.3_MAG
ENA-CHECKLISTERC000047
ENA-FIRST-PUBLIC2023-07-18T16:27:38Z
ENA-LAST-UPDATE2023-07-18T16:27:38Z
External IdSAMEA114096467
INSDC center aliasEMG
INSDC center nameEMG
INSDC first public2023-07-18T16:27:38Z
INSDC last update2023-07-18T16:27:38Z
INSDC statuspublic
Submitter IdDRR221363_bin.37_MetaWRAP_v1.3_MAG
assembly qualityMany fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly softwaremetaspades v3.15.3
binning parametersMaxBin2, MetaBat2, Concoct with default parameter of the metaWRAP pipeline. Bin refinement module used from metaWRAP with default parameters.
binning softwareMetaWRAP v1.3
broker nameEMG broker account, EMBL-EBI
completeness score98.66
completeness softwareCheckM
contamination score0.34
geographic location (latitude)24.7
geographic location (longitude)113.6
local environmental contextcolon
metagenomic sourcehuman feces metagenome
sample derived fromSAMD00218069
scientific_nameuncultured Ruminococcus sp.
sequencing methodIllumina HiSeq 3000
taxonomic classificationThe taxonomy of this Metagenome-Assembled Genome was originally computed with GTDBtk, which assigned the following taxonomic annotation: d__Bacteria;p__Firmicutes;c__Clostridia;o__Eubacteriales;f__Oscillospiraceae;g__Ruminococcus;s__
taxonomic identity markermulti-marker approach
Description

This sample represents a Third Party Annotation (TPA) metagenome-assembled genome assembled from the metagenomic run DRR221363 of study DRP008416.

BioProject
PRJEB63337
Retrieve all samples from this project

Submission
EBI; 2023-07-21
Accession:
SAMEA114096467
ID:
36671501

BioProject Nucleotide

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