| broad-scale environmental context | Human digestive system |
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| collection date | 2019 |
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| environmental medium | faeces |
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| geographic location | Sweden |
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| investigation type | metagenome-assembled genome |
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| isolation source | human feces metagenome |
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| project name | Recent studies have shown that probiotic supplementation has beneficial effects on bone metabolism. In a randomized controlled trial (RCT) we demonstrated that supplementation of Lactobacillus reuteri ATCC PTA 6475 reduced bone loss in older women with low bone mineral density. To investigate the mechanisms underlying the effect of L. reuteri ATCC PTA 6475 on bone metabolism, 20 women with the highest changes (good responders) and the lowest changes (poor responders) in tibia total volumetric BMD after one-year supplementation were selected from our previous RCT. In the current study we characterized the gut microbiome composition and function as well as serum metabolome in good responders and poor responders to the probiotic treatment as a secondary analysis. |
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| sample name | ERR9762687_bin.10_MetaWRAP_v1.3_MAG |
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| ENA-CHECKLIST | ERC000047 |
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| ENA-FIRST-PUBLIC | 2023-07-13T20:35:05Z |
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| ENA-LAST-UPDATE | 2023-07-13T20:35:05Z |
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| External Id | SAMEA114064237 |
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| INSDC center alias | EMG |
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| INSDC center name | EMG |
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| INSDC first public | 2023-07-13T20:35:05Z |
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| INSDC last update | 2023-07-13T20:35:05Z |
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| INSDC status | public |
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| Submitter Id | ERR9762687_bin.10_MetaWRAP_v1.3_MAG |
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| assembly quality | Many fragments with little to no review of assembly other than reporting of standard assembly statistics |
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| assembly software | metaspades v3.15.3 |
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| binning parameters | MaxBin2, MetaBat2, Concoct with default parameter of the metaWRAP pipeline. Bin refinement module used from metaWRAP with default parameters. |
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| binning software | MetaWRAP v1.3 |
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| broker name | EMG broker account, EMBL-EBI |
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| completeness score | 100 |
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| completeness software | CheckM |
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| contamination score | 0.0 |
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| geographic location (latitude) | 6399670.28 |
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| geographic location (longitude) | 323762.97 |
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| local environmental context | colon |
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| metagenomic source | human feces metagenome |
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| sample derived from | SAMEA14418837 |
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| scientific_name | Sutterella wadsworthensis |
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| sequencing method | Illumina NovaSeq 6000 |
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| taxonomic classification | The taxonomy of this Metagenome-Assembled Genome was originally computed with GTDBtk, which assigned the following taxonomic annotation: d__Bacteria;p__Proteobacteria;c__Betaproteobacteria;o__Burkholderiales;f__Sutterellaceae;g__Sutterella;s__Sutterella wadsworthensis |
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| taxonomic identity marker | multi-marker approach |
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