Figure 2.

Figure 2.

Hematoxylin and eosin stain of quadriceps muscle of an infant with GARS1-iSMA at 4X (A) and 10X (B) magnification showing findings typical of spinal muscular atrophy

A. Low power magnification demonstrates small atrophied fibers with marked variation in fiber size. Inflammatory cells are absent, and there is no increase in endomysial connective tissue.

B. Higher power magnification demonstrates clusters of large hypertrophied muscle fibers among large groups of small often rounded, atrophic muscle fibers.

From: GARS1-Associated Axonal Neuropathy

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