Web Appendix 4Summary of a systematic review on screening for extended spectrum beta-lactamase and the impact on surgical antibiotic prophylaxis

Medline (via PubMed)

1. “surgical wound infection”[Mesh] OR (surgical site infection* [TIAB] OR “SSI” OR “SSIs” OR surgical wound infection* [TIAB] OR surgical infection*[TIAB] OR post-operative wound infection* [TIAB] OR postoperative wound infection* [TIAB] OR wound infection*[TIAB]) OR “preoperative Care”[Mesh] OR “preoperative care” OR “pre-operative care” OR “perioperative Care”[Mesh] OR “perioperative care” OR “peri-operative care”
2. “beta-lactamases”[Mesh] OR beta-lactamase* OR “ESBL” OR “ESBLs” OR “extended spectrum beta lactamase” OR ((expanded spectrum OR extended spectrum OR extended spectra OR expanded spectra) AND (lactam* or betalactam*)) OR ((“Escherichia coli”[Mesh] OR “Escherichia coli”) AND (“Enterobacteriaceae”[Mesh] OR “Enterobacteriaceae” OR “Klebsiella”))
3. “epidemiological monitoring”[Mesh] OR “monitoring” OR “surveillance” [TIAB] OR “screen” or “screening” or “screened” OR “test” or “tests” or “testing” or “tested” OR “routine testing” OR “routine screening” OR “carrier state”[Mesh] OR “carrier” OR “detection” OR “detecting” OR “colonization” OR “colonized” OR “prevalence”[Mesh] OR “prevalence” OR “incidence”[Mesh] OR “incidence”
4. “antibiotic prophylaxis”[Mesh] OR “antibiotic prophylaxis” OR “antibacterial agents”[Mesh] OR “antibacterial” OR “anti bacterial* OR antibiotic* OR prophyla* OR “carbapenems”[Mesh] OR carbapenem OR carbapenems
5. Step 1 AND Step 2 AND Step 3 AND Step 4

EMBASE

1. ‘beta lactamase’/exp OR ‘beta lactamase’ OR ‘beta-lactamase’/exp OR ‘beta-lactamase’ OR ‘beta-lactamases’/exp OR ‘beta-lactamases’ OR ‘esbl’/exp OR esbl OR ‘esbls’ OR ‘extended spectrum beta lactamase’/exp OR ‘extended spectrum beta lactamase’ OR (‘expanded spectrum’ OR ‘extended spectrum’ OR ‘extended spectra’ OR ‘expanded spectra’ AND (lactam* OR betalactam*)) OR (‘Escherichia coli’/exp OR ‘Escherichia coli’ AND (‘enterobacteriaceae infection’/exp OR ‘enterobacteriaceae infection’ OR ‘enterobacteriaceae’/exp OR ‘enterobacteriaceae’ OR ‘Klebsiella’/exp OR ‘Klebsiella’))
2. ‘epidemiological monitoring’/exp OR ‘epidemiological monitoring’ OR ‘incidence’ OR ‘prevalence’ OR ‘heterozygote’/exp OR ‘heterozygote’ OR ‘monitoring’/exp OR monitoring OR surveillance:ab,ti OR screen OR ‘screening’/exp OR screening OR screened OR test OR tests OR testing OR tested OR ‘routine testing’ OR ‘routine screening’ OR carrier OR detection OR detecting OR colonization OR colonized OR colonised OR colonisation OR ‘prevalence’/exp OR prevalence OR ‘incidence’/exp OR incidence
3. ‘anti-infective agent’ OR ‘anti-infective agents’/exp OR ‘anti-infective agents’ OR ‘antiinfective agent’/exp OR ‘antiinfective agent’ OR ‘antiinfective agents’ OR ‘carbapenem derivative’/exp OR ‘carbapenem derivative’ OR ‘antibiotic prophylaxis’/exp OR ‘antibiotic prophylaxis’ OR ‘antibacterial’/exp OR ‘antibacterial’ OR ‘anti bacterial’ OR antibiotic* OR prophyla* OR ‘carbapenem’/exp OR carbapenem OR ‘carbapenems’/exp OR carbapenems
4. #1 AND #2 AND #3
5. ‘surgical infection’/exp OR ‘surgical site infection’:ab,ti OR ‘surgical site infections’:ab,ti OR ssis OR ‘surgical infection wound’:ab,ti OR‘surgical infection wounds’:ab,ti OR ‘surgical infection’:ab,ti OR ‘postoperative wound infection’:ab,ti OR ‘postoperative wound infections’:ab,ti OR ‘post-operative wound infection’:ab,ti OR ‘post-operative wound infections’:ab,ti OR ‘wound infection’:ab,ti OR ‘wound infections’:ab,ti OR ‘preoperative period’/exp OR ‘perioperative period’/exp OR ‘preoperative care’ OR ‘pre-operative care’ OR ‘perioperative care’ OR ‘peri-operative care’
6. #4 AND #5

CINAHL

1. (MH surgical wound infection) OR (AB surgical site infection* OR AB SSI OR AB SSIs OR AB surgical wound infection* OR AB surgical infection* OR AB post-operative wound infection* OR AB postoperative wound infection* OR AB wound infection*) OR AB postoperative wound infection* OR AB wound infection*) OR (MH “perioperative care+”) OR AB preoperative care OR AB pre-operative care OR AB perioperative care OR AB peri-operative care
2. AB beta-lactamase OR AB beta lactamases OR AB ESBL OR AB ESBLs OR ((AB expanded spectrum OR AB extended spectrum OR AB extended spectra OR AB expanded spectra) AND (AB lactam* OR AB betalactam*)) OR (((MH “Escherichia coli”) OR (MH “Escherichia coli infections”) OR AB Escherichia coli) AND ((MH “Enterobacteriaceae”) OR (MH “Enterobacteriaceae infections”) OR AB Enterobacteriaceae OR AB Klebsiella))
3. (MH “epidemiology+”) OR (MH “Incidence”) OR (MH “Prevalence”) OR (MH “Carrier State”) OR AB monitoring OR AB surveillance OR AB screen or AB screening or AB screened OR AB test or AB tests or AB testing or AB tested OR AB routine testing OR AB routine screening OR AB carrier OR AB detection OR AB detecting OR AB colonization OR AB colonized OR AB colonised OR AB colonisation OR AB prevalence OR AB incidence (MH “antibiotic prophylaxis”) OR (MH “antiinfective agents+”) OR AB anti-infective agent OR AB anti-infective agents OR AB antiinfective agent OR AB antiinfective agents OR AB antibiotic prophylaxis OR AB antibacterial OR AB anti bacterial OR AB antibiotic* OR AB prophyla* OR AB carbapenem OR AB carbapenems OR (MH “carbapenems”)
4. #1 AND #2 AND #3

Cochrane CENTRAL

1.

MeSH descriptor: [surgical wound infection] explode all trees

2.

MeSH descriptor: [perioperative care] explode all trees

3.

MeSH descriptor: [preoperative care] explode all trees

4.

surgical site infections or SSI or SSIs or surgical wound infection* or surgical infection* or post-operative wound infection* or postoperative wound infection* or wound infection* or “preoperative care” or “pre-operative care” or “perioperative care” or “peri-operative care”:ti,ab,kw (word variations have been searched)

5.

#1 or #2 or #3 or #4

6.

MeSH descriptor: [beta-lactamases] explode all trees

7.

beta-lactamase* or “ESBL” or “ESBLs” or “extended spectrum beta lactamase”:ti,ab,kw (word variations have been searched) 432

8.

#6 or #7

9.

expanded spectrum or extended spectrum or extended spectra or expanded spectra:ti,ab,kw (word variations have been searched)

10.

lactam* or betalactam*:ti,ab,kw (word variations have been searched)

11.

#9 and #10

12.

MeSH descriptor: [Escherichia coli] explode all trees

13.

“Escherichia coli”:ti,ab,kw (word variations have been searched)

14.

#12 or #13

15.

MeSH descriptor: [Enterobacteriaceae] explode all trees

16.

“Enterobacteriaceae” or “Klebsiella”:ti,ab,kw (word variations have been searched)

17.

#15 or #16

18.

#14 and #17

19.

#8 or #11 or #18

20.

MeSH descriptor: [epidemiological monitoring] explode all trees

21.

MeSH descriptor: [carrier state] explode all trees

22.

MeSH descriptor: [prevalence] explode all trees

23.

MeSH descriptor: [incidence] explode all trees

24.

monitoring or surveillance or screen or screening or screened or test or tests or testing or tested or “routine testing” or “routine screening” or carrier or detection or detecting or colonization or colonized or prevalence or incidence:ti,ab,kw (Word variations have been searched)

25.

#20 or #21 or #22 or #23 or #24

26.

MeSH descriptor: [antibiotic prophylaxis] explode all trees

27.

MeSH descriptor: [anti-bacterial agents] explode all trees

28.

MeSH descriptor: [carbapenems] explode all trees

29.

antibiotic prophylaxis or antibacterial or anti bacterial* or antibiotic* or prophyla* or carbapenem or carbapenems:ti,ab,kw (word variations have been searched)

#30.

MeSH descriptor: [anti-infective agents] explode all trees

#31.

#26 or #27 or #28 or #29 or #30

#32.

#5 and #19 and #25 and #31

WHO Global Health Library

((ssi) OR (surgical site infection) OR (surgical site infections) OR (wound infection) OR (wound infections))

ti:

title;

ab:

abstract;

kw:

key word