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Carlson LM, Christensen K, Lehmann GM, et al. A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures. Washington (DC): U.S. Environmental Protection Agency; 2023 Mar.

Cover of A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures

A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures.

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ABBREVIATIONS

ACTH

adrenocorticotropic hormone

ALT

alanine aminotransferase

AOP

adverse outcome pathway

AhR

aryl hydrocarbon receptor

AST

aspartate aminotransferase

ATSDR

Agency for Toxic Substances and Disease Registry

BUN

blood urea nitrogen

BW

body weight

CASRN

Chemical Abstracts Service registry number

CERCH

Center for Environmental Research and Children’s Health

CNS

central nervous system

CPAD

Chemical and Pollutant Assessment Division

CPHEA

Center for Public Health and Environmental Assessment

CYP450

cytochrome P450 CYP1A2

DoCTER

Document Classification and Topic Extraction Resource

EPA

Environmental Protection Agency

EPM

elevated plus maze

EZM

elevated zero maze

FVC

forced vital capacity

FEV1

forceful exhalation

GGT

gamma-glutamyltransferase

GSH

glutathione

HAWC

Health Assessment Workspace Collaborative

HDL

low high-density lipoprotein

HERO

Health and Environmental Research Online

HF

heart failure

HPA

hypothalamus-pituitary-adrenal

HPT

hypothalamus-pituitary-thyroid

IGT

impaired glucose tolerance

i.p.

intraperitoneal

IR

insulin resistance

i.v.

intravenous

IARC

International Agency for Research on Cancer

IHD

ischemic heart disease

IRIS

Integrated Risk Information System

MCH

mean corpuscular hemoglobin

MCV

mean corpuscular volume

ML

machine learning

MetS

metabolic syndrome

MOA

mode of action

MI

myocardial infarction

NCI

National Cancer Institute

NHANES

National Health and Nutrition Examination Survey

NK

natural killer cells

NLP

natural language processing

NTP

National Toxicology Program

ORD

Office of Research and Development

OW/OB

overweight/obesity

PCBs

polychlorinated biphenyls

PCDFs

polychlorinated dibenzofurans

PECO

populations, exposures, comparators, and outcomes

PK

pharmacokinetic

QA

Quality Assurance

QAPP

Quality Assurance Project Plan

RBCs

red blood cells

SD

standard deviation

SE

standard error

SEMs

systematic evidence maps

SGOT

serum glutamic oxaloacetic transaminase, also known as AST

SGPT

serum glutamic pyruvic transaminase, also known as ALT

TCDD

2,3,7,8-tetrachlorodibenzo-p-dioxin

TK

toxicokinetics

TSCATS

Toxic Substances Control Act Test Submissions

TSH

thyroid stimulating hormone

T4

thyroxine

T3

triiodothyronine

WOS

Web of Science

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