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National Clinical Guideline Centre (UK). Care of Dying Adults in the Last Days of Life. London: National Institute for Health and Care Excellence (NICE); 2015 Dec 16. (NICE Guideline, No. 31.)
L.1. Recognising Dying
Table 93Studies excluded from the clinical review of Recognising dying
Reference | Reason for exclusion |
---|---|
Al 201018 | Incorrect study design, review |
Alzahrani 201319 | Incorrect population, not last days of life. |
Anon 2012a3 | Incorrect study design, abstract |
Asch 200530 | Incorrect study design, discussion/editorial |
Barbera 200845 | Incorrect population, not last days of life. |
Barrett 199746 | Incorrect population, not last days of life. |
Bern-Klug 200654 | Incorrect population, not last days of life. |
Campbell 201280 | Incorrect study design, non-systematic review |
Casscells 200587 | Incorrect population, not last days of life. |
Cheng 200992 | Incorrect study design, non-systematic review |
Cobb 2000108 | Incorrect population, not last days of life. |
Conill 1997111 | No relevant diagnostic or prognostic data: symptom prevalence |
Cuervopinna 2009118 | Incorrect population, not last days of life. |
Currow 2010121 | No relevant diagnostic or prognostic data: symptom prevalence |
Downing 2011138 | Incorrect study design, non-systematic review |
Dunn 2002140 | Incorrect study design, non-systematic review |
Dunning 2012141 | Incorrect study design, literature review |
Ellershaw 1995145 | No relevant diagnostic or prognostic data: symptom prevalence |
Fainsinger 1991154 | No relevant diagnostic or prognostic data: symptom prevalence |
Fantoni 1996155 | Incorrect population, not last days of life. |
Feliu 2011157 | Incorrect population, not last days of life. |
Fordyce 2001162 | Incorrect study design, discussion/editorial |
Fortinsky 2014163 | Incorrect study design, literature review |
Fromme 2004168 | No relevant diagnostic or prognostic data: symptom prevalence |
Georges 2005a174 | No relevant diagnostic or prognostic data: symptom prevalence |
Gibbins 2009175 | Incorrect study design, discussion/editorial |
Gilbertsonwhite 2011176 | Incorrect study design, non-systematic review |
Gilman 2009177 | Incorrect study design, non-systematic review |
Glare 2008179 | Incorrect study design, non-systematic review |
Goebel 2009182 | Incorrect population, not last days of life. |
Gonzales 2011184 | Incorrect study design, non-systematic review |
Goodman 2010185 | Incorrect study design, non-systematic review |
Greer 2013188 | Incorrect study design, literature review |
Hendriks 2014204 | No relevant diagnostic or prognostic data: symptom prevalence |
Hirakawa 2006210 | No relevant diagnostic or prognostic data: symptom prevalence |
Hirakawa 2006a.214 | No relevant diagnostic or prognostic data: symptom prevalence |
Hirakawa 2006b213 | No relevant diagnostic or prognostic data: symptom prevalence |
Hirakawa 2006c.212 | No relevant diagnostic or prognostic data: symptom prevalence |
Hirakawa 2006d.211 | No relevant diagnostic or prognostic data: symptom prevalence |
Huang 2014225 | Incorrect population, not last days of life. |
Hussain 2014232 | Incorrect population, not last days of life. |
Janssen 2008240 | Incorrect study design, non-systematic review |
Kehl 2013255 | Incorrect study design, non-systematic review |
Klinkenberg 2003263 | No relevant diagnostic or prognostic data: symptom prevalence |
Kompanje 2005264 | Incorrect study design, case report |
Kripp 2014266 | Incorrect population, not last days of life. |
Kutner 2001269 | Incorrect population, not last days of life. |
Kutner 2007270 | Incorrect population, not last days of life. |
Leak 2013277 | No relevant diagnostic or prognostic data: symptom prevalence |
Lee 2014a281 | Incorrect population, not last days of life. |
Levenson 2000284 | Incorrect population, not last days of life. |
Li 2008285 | Incorrect population, not last days of life. |
Lichter 1990286 | No relevant diagnostic or prognostic data: symptom prevalence |
Lindleydavis 1991291 | Incorrect population, not last days of life. |
Lindqvist 2008293 | Incorrect population, not last days of life. |
Liu 2013294 | Incorrect population, not last days of life. |
Lutz 2001301 | No relevant diagnostic or prognostic data: symptom prevalence |
Mastersoncreber 2013309 | Incorrect population, not last days of life. |
Mazzocato 2010312 | No relevant diagnostic or prognostic data: symptom prevalence |
Mccarthy 2000313 | No relevant diagnostic or prognostic data: symptom prevalence |
Mercadante 2000317 | Incorrect population, not last days of life. |
Morita 1998328 | No relevant diagnostic or prognostic data: symptom prevalence |
Morita 2003330 | No relevant diagnostic or prognostic data: symptom prevalence |
Moyer 2011331 | Incorrect study design, non-systematic review |
Munizterrera 2013332 | Incorrect population, not last days of life. |
Murphy 2010333 | Incorrect population, not last days of life. |
Murtagh 2010334 | Incorrect population, not last days of life. |
Nordgren 2003351 | No relevant diagnostic or prognostic data: symptom prevalence |
Olajide 2007358,358 | Incorrect population, not last days of life. |
Ostgathe 2008361 | Incorrect study design, non-systematic review |
Pace 2009363 | No relevant diagnostic or prognostic data: symptom prevalence |
Peppin 2003366 | Incorrect study design, non-systematic review |
Pinzon 2013370 | No relevant diagnostic or prognostic data: symptom prevalence |
Potter 2013373 | Incorrect study design, non-systematic review |
Price 2013b374 | Incorrect population, not last days of life. |
Radbruch 2008379 | Incorrect study design, Guideline |
Rashid i2011384 | No relevant diagnostic or prognostic data: symptom prevalence |
Richards 2011390 | Incorrect population, not last days of life. |
Ridley 2013391 | Incorrect study design, non-systematic review |
Roberts 1993394 | No relevant outcomes on management of uncertainty, or recognising dying. |
Saini 2006400 | Incorrect population, not last days of life. |
Salpeter 2012a402 | Incorrect study design, non-systematic review |
Seah 2005407 | No relevant diagnostic or prognostic data: symptom prevalence |
Skaug 2007415 | Incorrect population, not last days of life. |
Solano 2006418 | Incorrect population, not last days of life. |
Solano 2006418 | Incorrect study design, non-systematic review |
Spoozak 2013419 | No relevant diagnostic or prognostic data: symptom prevalence |
Suh 2013425 | Incorrect population, not last days of life. |
Sullivan 2008424 | No relevant outcomes on management of uncertainty, or recognising dying. |
Trueman 2011434 | Incorrect study design, Discussion/editorial |
Tsai 2006435 | No relevant diagnostic or prognostic data: symptom prevalence |
Vandervoort 2013446 | No relevant diagnostic or prognostic data: symptom prevalence |
Veerbeek 2007447 | No relevant diagnostic or prognostic data: symptom prevalence |
Ventafridda 1990a448 | No relevant diagnostic or prognostic data: symptom prevalence |
Vitacca 2012452 | No relevant diagnostic or prognostic data: symptom prevalence |
Vongunten 2005453 | Incorrect population, not last days of life. |
Vongunten 2005453 | Incorrect study design, non-systematic review |
Walbert 2014459 | Incorrect study design, non-systematic review |
Yamanaka 2011477 | Incorrect population, not last days of life. |
Yanneo 2009478 | Incorrect study design, non-systematic review |
Yong 2009481 | Incorrect population, not last days of life. |
Zambroski 2005484 | No relevant diagnostic or prognostic data: symptom prevalence |
L.2. Communications
Table 94Studies excluded from the clinical review of Communications
Reference | Reason for exclusion |
---|---|
Abarshi 20115 | Topic does not match protocol (discussion of prognosis before last weeks of life) |
Abarshi 20114 | Topic does not match protocol (occurrence of communication) |
Abdul-Razzak 20147 | Population does not match protocol (death not imminent) |
Adamolekun 199811 | Indirect population (communication in a developing country) |
Adelman 199414 | Population does not match protocol (death not imminent) |
Anderson 201024 | Abstract only |
Anderson 201326 | Topic does not match protocol (describing communication in end-of-life care conversations) |
Apatira 200829 | Topic does not match protocol (balance of hope and truth) |
Azoulay 200933 | Topic does not match protocol (conflicts in ITU) |
Bachner 201436 | Full text unavailable |
Bajwah 201341 | Population does not match protocol |
Bakitas 200843 | Topic does not match protocol (quality of end of life care) |
Bailey39 | Topic does not match protocol (opioid use) |
Barry 200247 | Topic does not match protocol (barriers to preparedness for death) |
Beckstrand 200849 | Topic does not match protocol (barriers and facilitators to end of life care) |
Bekkema 201450 | Topic does not match protocol (barriers and facilitators to respecting autonomy) |
Bern-Klug 200455 | Topic does not match protocol (quality of end of life care) |
Biola 200756 | Topic does not match protocol (occurrence of communication) |
Bradby 201361 | Population does not match protocol (death not imminent) |
Broom 201465 | Full text unavailable |
Bruera 200071 | Topic does not match protocol (perceived need for communication) |
Butow 201478 | Abstract only |
Cherlin 200593 | Topic does not match protocol (timing and content of discussion) |
Clarke 2006100 | Topic does not match protocol (conversations at end of life) |
Clayton 2005102 | Population does not match protocol (death not imminent) |
Clayton 2005103 | Population does not match protocol (death not imminent) |
Clover 2004107 | Topic does not match protocol (decision making techniques) |
Conboy-Hill 1986110 | Incorrect study design (descriptive not analytic) |
Considine 2010112 | Topic does not match protocol (managing dialectical tensions) |
Crawford 2010116 | Population does not match protocol (death not imminent) |
Csikai 2006117 | Population does not match protocol (death not imminent) |
Curtis 2008126 | Population does not match protocol (death not imminent) |
Curtis 2004122 | Topic does not match protocol (end-of-life planning) |
Curtis 1999124 | Incorrect study design (descriptive not analytic) |
Curtis 2000125 | Topic does not match protocol (end-of-life planning) |
Curtis 1997123 | Topic does not match protocol (palliative care) |
El-Sahwi 2012144 | Incorrect study design (descriptive not analytic) |
Emanuel 2004146 | Topic does not match protocol (effects of communication) |
Endacott 2013147 | Abstract only |
Enguidanos 2014148 | Incorrect study design (descriptive not analytic) |
Evans 2009150 | feelings about uncertainty in prognostic community |
Evans 2014151 | Incorrect study design (descriptive not analytic) |
Evans 2012152 | Population does not match protocol (death not imminent) |
Exline 2012153 | Topic does not match protocol (communication within families) |
Friedrichsen 2000166 | Incorrect study design (descriptive not analytic) |
Gadoud 2013170 | Abstract only |
Granek 2013186 | Topic does not match protocol (end-of-life planning) |
Gutierrez 2012192 | Incorrect study design (descriptive not analytic) |
Hack 2010193 | Incorrect study design (descriptive not analytic) |
Hagerty 2004194 | Topic does not match protocol (need for prognosis) |
Hagerty 2005195 | Population does not match protocol (death not imminent) |
Hjelmfors 2013216 | Abstract only |
Hjelmfors 2013217 | Abstract only |
Hjelmfors 2014219 | Topic does not match protocol (occurrence of communication) |
Hjelmfors 2014218 | Population does not match protocol (death not imminent) |
Hjorleifsdottir 2000220 | Population does not match protocol (death not imminent) |
Hofmann 1997222 | Topic does not match protocol (care planning discussion) |
Jackson 2012237 | Population does not match protocol (death not imminent) |
Janssen 2011239 | Topic does not match protocol (care planning discussion) |
Kai 1993247 | Topic does not match protocol (care planning discussion) |
Kaplowitz 2002252 | Population does not match protocol (death not imminent) |
Klindtworth 2012262 | Abstract only |
Kozar 2014265 | Full text unavailable |
Lawrence 2013275 | Population does not match protocol (death not imminent) |
Lofmark 2005297 | Topic does not match protocol (occurrence of communication) |
Marcus 2014307 | Abstract only |
Nedjat-Haiem 2011346 | Abstract only |
Norton 2013353 | Incorrect study design (descriptive not analytic) |
Norton 2000352 | Topic does not match protocol (decision making) |
Palmer 2012364 | Abstract only |
Puntillo 2006377 | Incorrect study design (review) |
Randhawa 2003383 | Topic does not match protocol (general palliative care) |
Reinke 2008387 | Population does not match protocol (death not imminent) |
Reinke 2010388 | Incorrect study design (observational study describing practice) |
Rhondali 2014389 | Incorrect study design (observational study describing practice) |
Roscoe 2013397 | Topic does not match protocol (planning end of life care) |
Stallworthy 2014420 | Abstract only |
Tang 2014428 | Topic does not match protocol (planning end of life care) |
Tomlinson 2012433 | Topic does not match protocol (written information only) |
Van Der Wal 2014444 | Abstract only |
Voorhees 2009454 | Incorrect study design (observational study describing practice) |
Vvedenskaya 2010455 | Abstract only |
Vvedenskaya 2012456 | Abstract only |
Vvedenskaya 2009457 | Abstract only |
Wadensten 2007458 | Incorrect study design (observational study describing practice) |
Walczak 2013461 | Population does not match protocol (death not imminent) |
Walczak 2010460 | Population does not match protocol (death not imminent) |
Waldrop 2012462 | Topic does not match protocol (communication before death imminent) |
Weinandy 1997465 | Abstract only |
Wenrich 2001466 | Population does not match protocol (death not imminent) |
Wilkinson 2014469 | Population does not match protocol (death not imminent) |
Witkamp 2010473 | Abstract only |
Yin 2007480 | Topic does not match protocol (perceptions of communication) |
You 2014482 | Topic does not match protocol (importance of communication) |
Young 2006483 | Topic does not match protocol (discussion of use of narrative) |
L.3. Shared Decision Making
Table 95Studies excluded from the clinical review of Shared decision making
Reference | Reason for exclusion |
---|---|
Adams 201412 | Indirect population: healthcare professionals in the USA |
Bach 2009 35 | Indirect population: healthcare professionals in Canada |
Grbich 2006 187 | Indirect population: healthcare professionals in Australia |
Hilden 2006 206 | Indirect population: healthcare professionals in Finland |
Hilden 2006 207 | Indirect population healthcare professionals in Finland |
Jensen 2013 243 | Indirect population: healthcare professionals in Finland |
Lee 2009 280 | Indirect population: not in the last days of life. |
Macdonald 2011 302 | Indirect topic. The study focussed on an ethicist which does not apply to standard care in the UK. . |
Oberle 2001 357 | Indirect population: healthcare professionals in Canada |
Ostertag 2008 360 | Indirect population: healthcare professionals and family members in the USA |
Radwany 2009 381 | Indirect population: healthcare professionals in the USA |
Reed 2011386 | Non peer reviewed journal and poor quality, discussed with the Committee and excluded. |
Ryan 2011 399 | Indirect population: healthcare professionals in the Republic of Ireland |
Samara 2013 403 | Indirect population: healthcare professionals in Australia |
L.4. Maintaining Hydration
Table 96Studies excluded from the clinical review of clinically assisted hydration
Reference | Reason for exclusion |
---|---|
Boland 201357 | Systematic review that did not match protocol- included studies that were not controlled |
Nwosu 2014355 | Systematic review that did not match protocol- assessment of hydration status only |
Fritzon 2013167 | Retrospective study investigating people receiving fluids in the last day and week of life. |
L.5. Pharmacological Intervention
Table 97Studies excluded from the clinical reviews on anxiety, agitation, breathlessness, delirium and pain
Study | Exclusion reason |
---|---|
Abernethy 20039 | Not guideline condition |
Abernethy 201010 | Not guideline condition |
Abernethy 20118 | Not guideline condition |
Ahmedzai 199716 | Not guideline condition |
Ahmedzai 200417 | Not guideline condition |
Allard 199920 | Incorrect interventions |
Andersen 198823 | Incorrect interventions |
Anderson 200425 | Systematic review is not relevant to review question or unclear PICO |
Aurora 201232 | Systematic review is not relevant to review question or unclear PICO |
Bach 201334 | Not guideline condition |
Bailey 201440 | Incorrect interventions |
Bajwah 201342 | Systematic review: quality assessment is inadequate. Systematic review is not relevant to review question or unclear PICO |
Bandieri 201244 | Not guideline condition. Incorrect interventions |
Bausewein 201348 | Systematic review is not relevant to review question or unclear PICO |
Ben-Aharon 200851 | Systematic review is not relevant to review question or unclear PICO |
Ben-Aharon 201252 | Systematic review is not relevant to review question or unclear PICO |
Benitez-Rosario 200453 | Not guideline condition |
Booth 200460 | Systematic review is not relevant to review question or unclear PICO |
Breitbart 199663 | Not guideline condition |
Brescia 198764 | Not guideline condition |
Bruera 198572 | Not guideline condition |
Bruera 199070 | Not guideline condition |
Bruera 199274 | Not guideline condition |
Bruera 199369 | Not guideline condition |
Bruera 199367 | Not guideline condition |
Bruera 200375 | Not guideline condition |
Bush 201476 | Systematic review is not relevant to review question or unclear PICO |
Cadth 201479 | Systematic review: methods are not adequate or unclear |
Campbell 201381 | Not review population |
Candy 201283 | Systematic review is not relevant to review question or unclear PICO |
Candy 201284 | Not guideline condition |
Chan 201389 | Not guideline condition |
Charles 200891 | Not guideline condition |
Chew 201194 | Not guideline condition |
Clemens 2011104 | Not guideline condition |
Clemens 2011105 | Not guideline condition. Incorrect study design |
Coyne 2002114 | Not guideline condition |
Cranston 2008115 | Systematic review: withdrawn from publication |
Currow 2009119 | Not guideline condition |
Dale 2011127 | Systematic review is not relevant to review question or unclear PICO |
Danoff 2013128 | Systematic review: methods are not adequate or unclear |
Daud 2007130 | Systematic review: methods are not adequate or unclear |
Dietz 2013134 | Systematic review: quality assessment is inadequate |
Douglas 2009137 | Systematic review: quality assessment is inadequate |
Dudgeon 2007139 | Not guideline condition |
Eaton 1999142 | Not guideline condition |
Flume 2002161 | Systematic review: methods are not adequate or unclear |
Frank 1997165 | Systematic review is not relevant to review question or unclear PICO |
Gamborg 2013171 | Not guideline condition. Incorrect interventions |
Ganzini 2007172 | Incorrect study design |
Generali 2004173 | Systematic review: methods are not adequate or unclear |
Girard 2010178 | Not guideline condition |
Gomutbutra 2013183 | Not guideline condition |
Grosset 2005190 | Not guideline condition |
Hardy 1998197 | Not guideline condition. Not review population |
Harlow 2011198 | Not guideline condition |
Harris 2003201 | Not guideline condition |
Harris 2014200 | Not guideline condition |
Hinkka 2001208 | Inappropriate comparison |
Hochgerner 2009221 | Systematic review: quality assessment is inadequate |
Hui 2013229 | Not guideline condition |
Hunt 1999230 | Not guideline condition |
Husic 2011231 | Not guideline condition |
Imanaka 2013233 | Not guideline condition |
Israel 2010234 | Not guideline condition |
Jackson 2004238 | Not guideline condition |
Jennings 2001 241 | Systematic review is not relevant to review question or unclear PICO |
Jennings 2003242 | Systematic review: methods are not adequate or unclear |
Johnson 2013245 | Not guideline condition |
Kallet 2007248 | Systematic review is not relevant to review question or unclear PICO. Systematic review: literature search not sufficiently rigorous. Systematic review: quality assessment is inadequate |
Kamboj 2005250 | Not guideline condition |
Kamboj 2014249 | Not guideline condition |
Keeley 2009254 | Systematic review is not relevant to review question or unclear PICO |
Kehl 2004256 | Systematic review is not relevant to review question or unclear PICO |
Kestenbaum 2014258 | Systematic review: literature search not sufficiently rigorous. Systematic review: quality assessment is inadequate |
King 2011259 | Systematic review is not relevant to review question or unclear PICO |
King 2011260 | Systematic review is not relevant to review question or unclear PICO |
Kurita 2011268 | Systematic review is not relevant to review question or unclear PICO |
Lauretti 1999272 | Not guideline condition |
Leblanc 2014278 | Not guideline condition |
Lebon 2009279 | Systematic review: literature search not sufficiently rigorous. Systematic review: study designs inappropriate |
Legge 2006282 | Systematic review: methods are not adequate or unclear |
Lennernas 2010283 | Not guideline condition |
Lorenz 2008299 | Systematic review: quality assessment is inadequate |
Sayed 2014404 | Not guideline condition |
Maltoni 2012304 | Palliative sedation |
Marinangeli 2004308 | Not guideline condition |
Mazzocato 1999311 | Not guideline condition |
Mcnamara 2002315 | Not guideline condition |
Mercadante 1998316 | Not guideline condition |
Mercadante 2002 319 | Not guideline condition |
Mercadante 2004320 | Not guideline condition |
Mercadante 2007322 | Not guideline condition |
Mercadante 2012318 | Not guideline condition |
Mercadante 2013321 | Not guideline condition |
Miller 2014323 | Not review population |
Moore 1994325 | Not guideline condition |
Morgan 1994326 | Incorrect study design |
Morita 2005329 | Not guideline condition |
Mystakidou 2004338 | Not guideline condition |
Mystakidou 2005336 | Not guideline condition |
Naing 2013339 | Systematic review is not relevant to review question or unclear PICO |
Naqvi 2009340 | Systematic review: methods are not adequate or unclear |
Nava 2013343 | Not guideline condition |
Navigante 2003344 | Not in English language |
Nicholson 2007349 | Systematic review is not relevant to review question or unclear PICO |
Oxberry 2009362 | Systematic review: methods are not adequate or unclear |
Parlow 2005365 | Not guideline condition |
Peterson 1996368 | Not guideline condition |
Philip 2006369 | Not guideline condition |
Plonk 2005371 | Incorrect study design |
Popiela 1989372 | Not guideline condition |
Raffa 2012382 | Systematic review: methods are not adequate or unclear |
Rauck 2009385 | Not guideline condition |
Ripamonti 1999392 | Systematic review: methods are not adequate or unclear |
Ripamonti 2000393 | Incorrect interventions |
Rodrigues 2004395 | Not guideline condition |
Rodriguez 2007396 | Not guideline condition |
Salas 2012401 | Not guideline condition |
Schultheis 2005405 | Incorrect study design |
Sim 2014411 | Systematic review: literature search not sufficiently rigorous |
Simon 2010413 | Not guideline condition |
Simon 2012412 | Not English language |
Sittl 2003414 | Not guideline condition |
Smith 2002416 | Not guideline condition |
Stiefel 2004422 | Systematic review: methods are not adequate or unclear. Systematic review is not relevant to review question or unclear PICO |
Thomas 2009430 | Not guideline condition |
Tse 2012436 | Incorrect interventions |
Twycross 1985440 | Not guideline condition |
Uronis 2008443 | Systematic review: methods are not adequate or unclear |
Uronis 2008442 | Not guideline condition. Systematic review is not relevant to review question or unclear PICO |
Viola 2008451 | Systematic review is not relevant to review question or unclear PICO |
Wang 2012464 | Systematic review is not relevant to review question or unclear PICO. Systematic review: quality assessment is inadequate |
Wiffen 2014467 | Not guideline condition |
Williams 2011471 | Systematic review: methods are not adequate or unclear |
Wootton 2004474 | Systematic review is not relevant to review question or unclear PICO |
Wyne 2011475 | Systematic review is not relevant to review question or unclear PICO |
Xu 1997476 | Not guideline condition |
Yates 2013479 | Systematic review: methods are not adequate or unclear |
Zeppetella 2000485 | Not guideline condition |
Zeppetella 2001486 | Not guideline condition |
Zeppetella 2010487 | Not guideline condition |
Zerzan 2010488 | Incorrect study design |
L.5.1. Nausea and Vomiting
Author | Exclusion reason |
---|---|
Bruera 200066 | Incorrect population, not in the last days of life. |
Clark 201398 | Cochrane review- protocol only. |
Corli 1995113 | Incorrect population, not in the last days of life. |
Currow – unpublished data120 | Incorrect population, not in the last days of life. |
Darvil 2013129 | Systematic review, did not match our protocol. Found no studies of levomepromazine in the last days of life. |
Davis 2002131 | Narrative review |
Davis 2010 | Systematic review, different PICO question: not limited to the last days of life. |
Dean 2001132 | Narrative review |
Dietz 2013134 | Systematic review- did not match our population, included studies focused on chemotherapy/radiotherapy induced nausea. |
Dorman 2010136 | Systematic review, did not match our protocol. |
Eisenchlas 2005143 | Incorrect population, not in the last days of life. Open label prospective study design. |
Feuer 1999158 | Systematic review, different PICO question: not limited to the last days of life. Included unpublished data but limited data presented and none relevant to this PICO. |
Fowell 2004164 | Study design description only. |
Glare 2004181 | Systematic review- Incorrect population, not in the last days of life. |
Glare 2008179 | Narrative review |
Glare 2011180 | Narrative review |
Hardy 1998197 | Incorrect population, not in the last days of life. |
Hardy 2002196 | Incorrect population, not in the last days of life. |
Harris 2010199 | Narrative review |
Heegaard 2014202 | Conference abstract- Systematic review, limited write up available. |
Herndon 2002205 | Narrative review |
Laugsand 2011271 | Systematic review, different PICO question: opioid-induced nausea only, not limited to the last days of life and included interventions not included in our protocol, such as reducing dose of opioid. |
Laval 2000273 | Incorrect population, not in the last days of life. |
Laval 2012274 | Incorrect population, not in the last days of life |
Magee 2014303 | Conference abstract- Systematic review, limited write-up available. |
Mangili 2005305 | Incorrect population, not in the last days of life. |
McLean 2013314 | Systematic review- did not match our population, included studies focused on post-operative nausea. |
Mystakidou 1998335 | Incorrect population, not in the last days of life. |
Mystakidou 2010337 | Incorrect population- patients receiving chemotherapy/radiotherapy. |
O'Neill 1999356 | Opinion piece. |
Perkins 2009367 | Systematic review, did not match our protocol. Found no studies of haloperidol in the last days of life. |
Prommer 2012375 | Literature review. Found no controlled studies of haloperidol in the last days of life. |
Prommer 2012376 | Literature review. |
Tatum 2009429 | Systematic review- summarised another Cochrane whose protocol did not match. |
Tuca 2009437 | Incorrect population, not in the last days of life. |
Tygat 2009 | Systematic review, did not match our protocol. Found no studies of hyoscine butylbromide used for nausea in the last days of life. |
L.5.2. Noisy Respiratory Secretions
Table 98Studies excluded from the clinical review of Noisy respiratory secretions
Study | Exclusion reason |
---|---|
Ahamed 201115 | Not the protocol condition: breathlessness rather than respiratory secretion |
Bailey 201440 | Intervention does not match the protocol - staff training |
Campbell 201382 | Comparison does not match the protocol - people with death rattle compared with people without death rattle |
Chapman 201190 | Narrative review |
Clark 200999 | Narrative review |
Clary 2009101 | Background (general pharmacological management at the end of life) |
Furst 2012169 | Background (general pharmacological management at the end of life) |
Hipp 2009209 | Narrative review |
Hirsch 2013215 | Qualitative (focus group) study |
Kintzel 2009261 | Systematic review without quality assessment |
Lindqvist 2013292 | Background (Delphi consensus on drugs needed for dying people) |
Lokker 2014298 | Systematic review (cross-checked for references) |
Lundquist 2011300 | Related to communication about dying |
Manthous 2013306 | Commentary |
Nunn 2014354 | Background (symptom management) |
Radbruch 2012378 | Background (pharmaceutical management of dying people) |
Sheehan 2011409 | Prognostic study for noisy respiratory secretions (factors predictive or protective) |
Shimizu 2014410 | Survey study |
Smucker 2010417 | Commentary (related to long term care) |
Twomey 2013438 | Narrative review |
L.6. Anticipatory Prescribing
Table 99Studies excluded from the clinical review of Anticipatory prescribing
Reference | Reason for exclusion |
---|---|
Amass 2005 22 | Opinion piece |
Anon 20112 | Opinion piece |
Anon 20081 | Opinion piece |
Anquinet 201527 | Indirect topic of questioning: related to terminal sedation in home settings |
Bailey 200538 | Indirect intervention where anticipatory prescribing in a hospital setting was 1 component of a multiprofessional intervention |
Butler 2013 77 | Narrative review |
Finucane 2014160 | Descriptive date indirect to context of access. |
Griggs 2010189 | Indirect topic of questioning: related to nursing staffs beliefs of a ‘good death’ |
Jack 2013235 | Indirect topic of questioning: evaluation of hospice at home service |
Lawton 2012 276 | Non controlled intervention. |
Oliver 2010 359 | Indirect topic of questioning: comfort care packs not consisting of pharmacological interventions in the terminally ill |
Radly 1998380 | Opinion piece |
Scott-Ation 2009 406 | Not qualitative research |
Stone 2013423 | Indirect context. |
- Excluded clinical studies - Care of Dying Adults in the Last Days of LifeExcluded clinical studies - Care of Dying Adults in the Last Days of Life
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