NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
National Clinical Guideline Centre (UK). Care of Dying Adults in the Last Days of Life. London: National Institute for Health and Care Excellence (NICE); 2015 Dec 16. (NICE Guideline, No. 31.)
Drug | Preparation | Units/pack | Cost/pack | Cost/unit(a) | Usual 24 hour dose | Cost/day | Source(b) |
---|---|---|---|---|---|---|---|
Alfentanil | 1 mg/2 ml solution for injection ampoules | 10 | £3.50 | £0.35 | 0.5-no max | £0.35 | eMIT109 |
Atropine | 600 micrograms/1 ml solution for injection ampoules | 10 | £11.70 | £1.17 | 0.4mg | £1.17 | NHS Drug Tariff, December 2014347 |
Buprenorphine | 10 micrograms/hour transdermal patches | 4 | £31.56 | £7.89 | Changed every 7 days | £1.12 | NHS Drug Tariff, March 2015348 |
Buprenorphine | 200 microgram sublingual tablets sugar free | 50 | £5.04 | £0.10 | 800-1200mcg | £0.80 - £1.20 | NHS Drug Tariff, March 2015348 |
Clonazepam | 1mg/ml injection ampoules | 1 | £6.00 | £6.00 | 1-8mg (depending on indication) | £6.00 - £48.00 | Palliative Care Formulary (PCF5)441 |
Clonazepam | 2 mg tablets | 100 | £8.97 | £0.09 | 0.5mg | £0.09 | NHS Drug Tariff, March 2015348 |
Cyclizine | 50 mg tablets | 100 | £11.26 | £0.11 | 150 mg | £0.33 | NHS Drug Tariff, December 2014347 |
Cyclizine | 50 mg/1 ml solution for injection ampoules | 5 | £8.65 | £1.73 | 150mg | £5.19 | NHS Drug Tariff, December 2014347 |
Dexamethasone | 2mg/5ml oral solution sugar free | 150ml | £42.30 | £0.28 | 4mg | £2.82 | NHS Drug Tariff, March 2015348 |
Dexamethasone | 4mg/ml ampoules for injection | NA | NA | £1.99 | 2-16mg | £1.98 - £7.96 | BNF 2015246 |
Dexamethasone | 2 mg tablets | 50 | £49.45 | £0.99 | 4mg | £1.98 | NHS Drug Tariff, December 2014347 |
Dexamethasone | 500 micrograms tablets | 28 | £60.50 | £2.16 | 4mg | £17.28 | NHS Drug Tariff, December 2014347 |
Diamorphine | 10 mg powder for solution for injection ampoules | 5 | £14.05 | £2.81 | 5 - no max dose | £2.81 | NHS Drug Tariff, March 2015348 |
Diazepam | 5 mg/2.5 ml rectal solution tube | 5 | £7.35 | £1.47 | 5-30mg | £1.47 - £8.82 | NHS Drug Tariff, March 2015348 |
Diclofenac | 100mg suppositories | 10 | £3.03 | £0.30 | 100 mg | £0.30 | NHS Drug Tariff, March 2015348 |
Diclofenac | 75 mg/3 ml solution for injection ampoules | 10 | £8.26 | £0.83 | 100 – 150 mg | £0.83 - £1.66 | NHS Drug Tariff, March 2015348 |
Domperidone | 10 mg tablets | 30 | £2.06 | £0.07 | 30mg | £0.21 | NHS Drug Tariff, December 2014347 |
Domperidone | 10 mg tablets | 100 | £6.87 | £0.07 | 30mg | £0.21 | NHS Drug Tariff, December 2014347 |
Domperidone | 5 mg/5 ml oral suspension 200 ml | 200 | £13.32 | £0.07 | 30mg | £2.00 | NHS Drug Tariff, December 2014347 |
Fentanyl | 100 microgram buccal tablets sugar free | 28 | £139.42 | £4.99 | Variable 100-800mcg | £4.99 - £39.92 | NHS Drug Tariff, March 2015348 |
Fentanyl | 25 micrograms/hour transdermal patches | 5 | £18.00 | £3.60 | 1 patch every 3 days | £1.20 | NHS Drug Tariff, March 2015348 |
Fosaprepitant | 150 mg per vial powder for reconstitution (vial) | 1 | £47.42 | £47.42 | 150mg | £47.42 | BNF December 2014246 |
Furosemide | 10mg/ml ampoules for injection | NA | NA | £0.50 per 2ml ampoules | 40-160mg | £1.00 - £4.00 | Palliative Care Formulary (PCF5)441 |
Glycopyrronium bromide | 0.2 mg/mL solution for injection ampoules | 3ml | £1.50 | £0.50 | 0.6 mg | £1.50 | BNF December 2014246 |
Granisetron | 3.1mg/24 hours patches | 1 | £56.00 | £56.00 | 1 patch for 5 days | £11.20 | BNF December 2014246 |
Granisetron hydrochloride | 1mg/mL solution for injection ampoules | 3 | £2.40 | £0.80 | 9 mg | £7.20 | BNF December 2014246 |
Haloperidol | 5 mg/1 ml solution for injection ampoules | 5 | £1.82 | £0.36 | 1.5mg | £0.36 | NHS Drug Tariff, March 2015348 |
Haloperidol | 500microgram capsules | 30 | £1.18 | £0.04 | 1.5mg | £0.12 | NHS Drug Tariff, March 2015348 |
Haloperidol | 1.5 mg tablets | 28 | £2.50 | £0.09 | 1.5mg | £0.09 | NHS Drug Tariff, December 2014347 |
Haloperidol | 5 mg/5 ml oral solution | 100 | £6.41 | £0.06 | 1.5mg | £0.09 | NHS Drug Tariff, December 2014347 |
Hydromorphone | 10mg/ml ampoules for injection | NA | NA | £9.00 | 2mg – no max | £9.00 | Palliative Care Formulary (PCF5)441 |
Hyoscine butylbromide | 20 mg/1 ml solution for injection ampoules | 10 | £2.92 | £0.29 | 60mg | £0.87 | NHS Drug Tariff, December 2014347 |
Hyoscine hydrobromide | 400 micrograms/1 ml solution for injection ampoules | 10 | £30.51 | 3.05 | 0.4mg | £3.05 | NHS Drug Tariff, December 2014347 |
Ketorolac | 30 mg/1 ml solution for injection ampoules | 6 | £3.99 | £0.67 | 60-90mg | £1.34 - £2.01 | eMIT109 |
Levomepromazine | 25 mg/1 ml solution for injection ampoules | 10 | £20.13 | £2.01 | 6mg | £2.01 | NHS Drug Tariff, March 2015348 |
Lorazepam | 1 mg tablets sublingual | 28 | £2.52 | £0.09 | 0.5-4mg | £0.09 - £0.36 | NHS Drug Tariff, March 2015348 |
Metoclopramide | 10 mg tablets | 28 | £0.97 | £0.03 | 30mg | £0.09 | NHS Drug Tariff, December 2014347 |
Metoclopramide | 10 mg/2 ml solution for injection ampoules | 10 | £3.15 | £0.32 | 30mg | £1.92 | NHS Drug Tariff, December 2014347 |
Metoclopramide | 5 mg/5 ml oral solution 150 ml | 150 | £19.60 | £0.13 | 30mg | £3.90 | NHS Drug Tariff, December 2014347 |
Midazolam | 10 mg/2 ml solution for injection ampoules | 10 | £1.60 | £0.16 | 10-60mg (but can be higher) | £0.16 | eMIT109 |
Midazolam | 2.5 mg/0.5 ml oromucosal solution pre-filled oral syringes | 4 | £82.00 | £20.50 | 10-30mg | £82.00 - £230.00 | NHS Drug Tariff, March 2015348 |
Morphine sulfate | 10 mg/1 ml solution for injection ampoules | 10 | £9.36 | £0.09 | 10mg – no max dose | £0.09 | NHS Drug Tariff, March 2015348 |
Morphine sulfate | 10mg/5ml oral solution | 300ml | £5.45 | £5.45 | 10mg – no max dose | £0.09 | NHS Drug Tariff, March 2015348 |
Octreotide | 500 micrograms/1 ml solution for injection ampoules | 5 | £135.47 | £27.09 | 0.25mg | £54.18 | NHS Drug Tariff, December 2014347 |
Olanzapine | 2.5 mg orodispersible tablets | 28 | £1.12 | £0.04 | 2.5-10mg | £0.04 - £0.16 | NHS Drug Tariff, March 2015348 |
Olanzapine | 10 mg orodispersible tablets | 28 | £3.43 | £0.12 | 2.5-10mg | £0.12 | NHS Drug Tariff, December 2014347 |
Olanzapine | 5 mg orodispersible tablets | 28 | £2.73 | £0.10 | 2.5-10mg | £0.10 | NHS Drug Tariff, December 2014347 |
Olanzapine | 5 mg orodispersible tablets | 28 | £3.66 | £0.13 | 2.5-10mg | £0.13 | NHS Drug Tariff, December 2014347 |
Ondansetron | 8 mg 0rodispersible tablets | 10 | £80.26 | £8.03 | 8mg | £8.03 | NHS Drug Tariff, December 2014347 |
Oxycodone | 10 mg/1ml solution for injection ampoules | 5 | £8.00 | £1.60 | 5-no max dose | £1.60 | NHS Drug Tariff, March 2015348 |
Oxycodone | 10 mg/ml oral solution sugar free | 120ml | £46.63 | £0.39 | 10- no max dose | £0.39 - maximum dose given | NHS Drug Tariff, March 2015348 |
Oxycodone | 50mg/1ml solution for injection ampoules | 5 | £70.01 | £14.01 | 5-no max dose | £14.01 - maximum dose given | NHS Drug Tariff, March 2015348 |
Palonosetron | 0.05 mg/ml solution for injection ampoules | 5 | £55.89 | £11.18 | 0.25mg | £55.90 | BNF December 2014246 |
Prochlorperazine | 12.5 mg/1 ml solution for injection ampoules | 10 | £5.23 | £0.52 | 2.5mg | £0.52 | NHS Drug Tariff, December 2014347 |
Prochlorperazine | 3 mg tablets | 28 | £1.03 | £0.04 | 6mg | £0.08 | NHS Drug Tariff, December 2014347 |
Prochlorperazine | 5 mg/5 ml oral solution | 100 | £3.34 | £0.03 | 5mg | £0.15 | NHS Drug Tariff, December 2014347 |
- a
Cost per unit for oral solutions is presented as £ per ml.
- b
Cost sources are given as they were when presented to the Committee.
- Unit Costs - Care of Dying Adults in the Last Days of LifeUnit Costs - Care of Dying Adults in the Last Days of Life
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