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WHO recommendation: Calcium supplementation during pregnancy for the prevention of pre-eclampsia and its complications. Geneva: World Health Organization; 2018.

Cover of WHO recommendation: Calcium supplementation during pregnancy for the prevention of pre-eclampsia and its complications

WHO recommendation: Calcium supplementation during pregnancy for the prevention of pre-eclampsia and its complications.

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5Research implications

The GDG identified important knowledge gaps that need to be addressed through primary research, which may have an impact on this recommendation. The following questions were identified as those that demand urgent priority:

  • What is the minimal dose and optimal commencement schedule for calcium supplementation to achieve a positive effect on pre-eclampsia and preterm birth?
  • What are the biological mechanisms underlying the relationships among calcium supplementation, pre-eclampsia, haemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome and preterm birth?
  • What is the most effective, acceptable and feasible regimen of recommended supplements (iron, calcium and folic acid)?
  • Can an intervention package with standardized guidance on nutrition be developed that is evidence-based, sustainable, reproducible, accessible and adaptable to different cultural settings?
  • What are the effects, feasibility, acceptability and equity implications of healthy eating and exercise interventions in LMICs?

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Bookshelf ID: NBK535802

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