Cervical cancer is the second most common cancer in women worldwide and the most common cancer in many low- and middle-income countries. However, precancerous lesions - cervical intraepithelial neoplasia or CIN - can be treated and cervical cancer prevented. This document summarizes the new evidence-based WHO recommendations about the use of cryotherapy to treat women with CIN. It also addresses the use of different techniques of cryotherapy for CIN and provides recommendations for treatment of CIN in women who are pregnant, as well as for women who are HIV-positive.

Contents

• Acknowledgements
• Declarations of interest
• Executive Summary
• Specific recommendations and their strength and quality of available evidence
• Introduction
• Methods
  • Formulating questions and determining outcomes
  • Expert guideline panel
  • Preparation of the evidence profiles and grading of the evidence
  • Development of recommendations
• Results
• Recommendations
  • Use of cryotherapy for prevention of CIN
  • Lesion size
  • Lesions extending into the endocervical canal
  • Cryotherapy technique and procedure
  • Providers
  • Use of cryotherapy during pregnancy
  • Retreatment of CIN lesions with cryotherapy
  • Education
• Discussion
• References
• Appendix A Search strategy for OVID MEDLINE
• Appendix B Summary tables for each recommendation
• Appendix C References used in creating the GRADE tables for the recommendations
• Evidence base

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