3LXU


Conserved Protein Domain Family
TPPII_N

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pfam12583: TPPII_N 
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Tripeptidyl peptidase II N terminal
This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with pfam00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.
Statistics
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PSSM-Id: 403697
Aligned: 7 rows
Threshold Bit Score: 192.453
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LXU_X              1035 SNGSSAAGST--ATAAAVTTANGAKPKAPatpQAATSV--TNPAAGDGISVQNDPPVDS-SGSPASPKKGKANADDYAES 1109 fruit fly
WGS:AAQB:GK21633-PB 1036 GNNNSSSNATp-AAAAVAVNANAAKPKAQ---QATVSV--NSPAAGDGVNTQTEPPVEN-GTGPGSPKKGKTSADDYAES 1108
WGS:AAPP:GF11981-PB 1035 GNGSSNAAST--AAAAAAATATAAKPKAPatpPAATSV--GNPAAGDGVNVQSDAPVEN-GGCPASPKKGKSNADDYAES 1109
XP_002016267        1109 GNGNSSANATvaAAAPAAVSANTTKPKAPatpPAATSInpANSAAGDGVATQTDTPAEG-NGSPASPKKGKTNSDEYSEI 1187
WGS:AAPU:GI19561-PB 1038 ANGAAASNAN---PAAAAASTNGVKPKPAstiQEEASA--ANSAGGDGVTSQTDGPANGcSGTPSSPQKGKAGADDYAES 1112
Q7Q974              1020 KKTSSTANAT--TGAANAVTNNATNGNIVan--------aGSNGTGNNVITATNGAANGsLPNGTAVKENRSKWDEYCEG 1089 Anophe...
ETN57947             968 VKKSTGSSSTvaTGSNGSGANNGG----------------GSPSCSSSEANGAEGAANT--------KENKAKWDEYIEG 1023
3LXU_X              1110 FRDFQCSQIVKCELEXAEKIYNDVVAAHPKHLQANLLLIQNIES-NQLK-SQLPLTFVNAQKT 1170 fruit fly
WGS:AAQB:GK21633-PB 1109 LRDFQCSHIVKGELELAEKIYQEVVAAHPKHLQAHLLLIQNIES-NQLKpNQLPLAFALGKEQ 1170
WGS:AAPP:GF11981-PB 1110 LRDFQCSYINKCELEMAEKIYGEVVAAHPKHLQAHLLLIQNIES-SQLK-AQLPLTFANAQNS 1170
XP_002016267        1188 LRDFQCTHIVKCEPEMAEKIYNEVVEAHPKHLQAHLLLIQNIEA-AQLK-SAFPLTFTNGQKS 1248
WGS:AAPU:GI19561-PB 1113 LRDFQCSHIAKCDLEKAEKIYNDVIAAHPKHLPAHLQLIQNIES-SELK-SLLPFAFVAAQQN 1173
Q7Q974              1090 LRDYQTAQISKLDAENAENVYQALLKDNPNHLAAHLAMADHFDS-TDLK-QNLPYTFTASFDA 1150 Anopheles gambiae str. ...
ETN57947            1024 LRDFQTAQIAKLDADNANNLYTKLLEEHPNHLAAHLAMVENIESgSDLKtTNLPYAFINSLDA 1086
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