6HC2


Conserved Protein Domain Family
NuMA_LGNBD
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cd22298: NuMA_LGNBD 
LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
NuMA, also called nuclear matrix protein-22 (NMP-22), nuclear mitotic apparatus protein 1 (NUMA1), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of spindle poles and the alignment and segregation of chromosomes during mitotic cell division. It is involved in the establishment of mitotic spindle orientation during metaphase, and elongation during anaphase in a dynein-dynactin-dependent manner. NuMA, in complex with LGN, forms NuMA:LGN hetero-hexamers that promote spindle orientation. The model corresponds to the LGN binding domain (LGNBD) of NuMA. LGN (named for leu-gly-asn repeats) is also known as G protein signaling modulator 2.
Links
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Statistics
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PSSM-Id: 412093
Aligned: 8 rows
Threshold Bit Score: 78.0228
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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LGN binding
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:LGN binding site [polypeptide binding site]
Evidence:
  • Comment:LGN is also known as G protein signaling modulator 2 (GPSM2)
  • Structure:6HC2; Homo sapiens NUMA1 in complex with GPSM2, forms a heterohexamer; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  ######                   ###  ## # #####    ###### #     
6HC2_B         13 LLSLPGYRPTTRSSarrsqagvssgapPGRNSFYMGTcQDEPEQl-DDWNRIAELQQRNR 71   human
Q14980       1870 LLSLPGYRPTTRSSarrsqagvssgapPGRNSFYMGTcQDEPEQl-DDWNRIAELQQRNR 1928 human
NP_001177854 1896 LLSLPGYRPATRSSlrrsqa--gssssLGRSSIYLGTcQDEPEQl-DDWNRIAELQQRNR 1952 chicken
XP_014348536 1985 VFKLPGYRPSTRSStrrsli-gdgataSAMSTFHLHScQNEPDQl-EDWNRIAELQQRNR 2042 coelacanth
XP_007909988 1816 LLSLPGYRPSTHGStrsst---fgsvvSNANTLYPGScQDEPEHl-DDWNRIAELQRRNG 1871 elephant shark
NP_001081559 1981 LNNLPGYQHPTRRSarl-------sqtGGRSSFYMSTcQDEPDPq-DDWTRIAELQARNK 2032 African clawed frog
NP_001316910 2159 LQNLPGYRRSTVHSvg---------ppRATSTFCIGA-ENEPEHaaDDWMRIAELQSRNK 2208 zebrafish
XP_006825523 1287 LASLNCTLDTTDKQt-----------tGRAGFVYMGGcEDEPEH--FDWDRVSEMQRRNT 1333 Saccoglossus kowalevskii

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