Conserved Protein Domain Family
FTO_CTD

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pfam12934: FTO_CTD 
FTO C-terminal domain
This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure. This domain is alpha helical with three helices that form a bundle.
Statistics
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PSSM-Id: 432887
Aligned: 7 rows
Threshold Bit Score: 224.272
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002287957    366 GTWQYIRDKTKQVLDAStk-------fNSSEKTCQASKKTFEKFVahVRLQQLLMNEVEFEWLRQWYVQGSKHASLHP-Y 437
XP_015223912    123 GTLDYIQRRCQEALKFL----------RSDLDSGTHTLRSLEPSV--LQHCEEIHNEVEFQWLRQYWFQGRRYEKFCS-W 189
XP_012409272    326 GTLDYILKQCQLVMQNV----------WDDMEPKTMHLRSLEPSV--VKQGEEIHNEVEFEWLRQFWFHGHRYKKCTD-W 392
jgi:OSTLU_17601 251 DTFQYIKRRCIDALAIVpd--------------lERENKPLDAKQ--IQFLADVHREVEFQWIRMFHLQGEAHAAWHDtY 314
ABY26524        334 DTFDYVRGRCERALAVLpslkwragrwPKGTKPPRDASSTQLSDA--VRVLGETHREVEFQWIRMFWLQGTRHAAQHDgY 411
XP_003060875    338 DTFEHIKTRCERALRLLpgikkiaqvgPGPGDDLAAFARS-------AQMMGETHRECEFQWIRMFWLQGSRHAASHSaY 410
XP_004347827    456 gTRDYIVNLCNSAIADA-----------------LISGSHFDLMS--VTKVQQALTEVECGWIRQFWAHGLRHARIQA-F 515
XP_002287957    438 WHQPIEVLCDSYSNMEQRSVDLLVR-MKRASHDNKTEtfnt-elsEDLFDVFIETLTERSNQRSGWTARYRDPIFGEIPA 515
XP_015223912    190 WRKPMEELEEAWRKMEIMTQLALAE-AEDAARTMERR--------REVAQVLLPFLTERQERRQLWRARCHSRLAQTLPP 260
XP_012409272    393 WHLPMSELEGLWKKMECVTNAVLCE-IRKEGLPMEQK--------NEIITDLLALLTTRQELRMEWCMRCQSRIAQNLPE 463
jgi:OSTLU_17601 315 WTRKIAELTEAWDRMEACFRVILSK-LKRSSRSPESP--------PRAYAMLLYALKTVKELRDEYTKRTKASAYASLPP 385
ABY26524        412 WTRRIEELTQAWDVMELGLRFAMDAcARAADGKAKAE--------PRAFEMLRYLLETIAELREEHDARTQSGAYAQVPD 483
XP_003060875    411 WRQRIAELTQAWDAMELGYRWALDA-LRAGASTGAMP--------LRAYDVVSYLLEETRELRAEHARRSRAGAYEAMPA 481
XP_004347827    516 WKRVIESLELQWQQLESLTRQSLDSiTRHMSEALHTAtksenariATICDALLKAFEHRLRLREQWANFYSSPDFDHMEN 595
XP_002287957    516 DERPFPCPLLDRtgdmtldeslkKGQMPEDLENVIAKLRE 555
XP_015223912    261 DEAPMCRPDWHDdd--------sSMPLPFDLKAIIDALER 292
XP_012409272    464 EQRPICWPYWEDdd--------pEMPLPFNLSNIILELQG 495
jgi:OSTLU_17601 386 SQRPVDLPAYDN-----------TSPLPFELKPVIYFLEE 414
ABY26524        484 DCKPVDLPGFDD-----------SSPLPRNLRPVLNTLER 512
XP_003060875    482 DCRPVDEPKFDE-----------KSPLPFDLGPVLATLAG 510
XP_004347827    596 DLLPVRRPHFSA-----------SSPLPEALEPKIAQLVk 624
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