5TOO,5EGH,5TCD,5VEM,4LQY,5M0E


Conserved Protein Domain Family
Phosphodiest

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pfam01663: Phosphodiest 
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Type I phosphodiesterase / nucleotide pyrophosphatase
This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Statistics
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PSSM-Id: 396300
Aligned: 67 rows
Threshold Bit Score: 112.9
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5TOO_A  21 VVGLVVDQMRWDYLYryyskyGEGGFKRMLN---TGYSLNnvHIDYVPTVSAIGHTSIFTGSVPSIHGIAGADWY----- 92  Elizabethkingia menin...
Q7MEK0  30 VLQITVDGLRGDLLDrykhnfAEKGFRYLMD---EGVYYTnaHYQHGNTETIVGHVSLATGAPPSVHGMVGNVWY----- 101 Vibrio vulnificus YJ016
Q84EY0  27 VVQLVIDQLRGDLIFqhqqqfGNGGFNYLLS---HAIDYHntHHPHANTTTCAGHATVATGSFPALHGIVNNEWY----- 98  Fluoribacter gormanii
Q89ZL4  29 VVGLTIDQLRTDYLEafsslyGERGFKRLWK---EGRVFHnaEYTFSGVDRASAMAAIYSGSTPSVNGIISNRWM----- 100 Bacteroides thetaiota...
Q55320  42 VVGMVIDQMRWDYLYrfyaryGNGGFKRLIN---EGFSAEntLIPYTPTLTACGHSSIYTGSVPAINGIIGNNWF----- 113 Synechococcus elongat...
Q6N507  30 LILFIPDGLRAKSVSp----eTAPAMAALRD---QGVNFKn-PHSLFPTFTMANGSAMATGHYLGDTGTFSNTIYtgysv 101 Rhodopseudomonas palu...
Q47910  31 VVGLVVDQMRWDYLYryydrySENGFKRLLN---EGFSSEntLIDYVPTYTAIGHSTIYTGSVPAINGIAGNDFI----- 102 Myroides odoratus
Q6A8W7  44 YVFLLVDGMGQENLEhf--rhLAPTLSEMKN---CHD-----LTCYVPSTTATSLSCIGTGAVPGCHGVVGYTFR----- 108 Cutibacterium acnes
Q73VT6  42 VLVLLVDGLGWQLLAql--agDAPLLAAVRA---GEVGRLtrLDCTFPSTTPTSLVSLATGAAPGQHGILGFTLR----- 111 Mycobacterium avium s...
O50518  58 NCVFLIDGLGWEQLRah--peDAPFLSSLLGssrGGTGRP--ITAGYPATTATSLASVGTGLPPGAHGLPGYTVR----- 128 Streptomyces coelicolor
5TOO_A  93 DKELGKS-VYCTSDETVqpvgttsn--------------svgqhspRNL---WSTtvtdqlglatnftSKVVGVSLADaa 154 Elizabethkingia menin...
Q7MEK0 102 DRQKERL-VYNVEDENYamlnshagvnkateidptqktalkdgrspQPI---LTTtfsdelalssngkAKVFSVSVKDrg 177 Vibrio vulnificus YJ016
Q84EY0  99 DRKSRQM-VYCMEDLKTnilqtshtr------------iaipgrspKNL---YVStlsdev--vlsqkGRVFGVSLKDrs 160 Fluoribacter gormanii
Q89ZL4 101 DVATLRP-VNSTDDAAFmgyytd------------------qtcapTKL---LTStiadelkiatqgkGIVYAIAPFCda 158 Bacteroides thetaiota...
Q55320 114 DPQLGRD-VYCVEDKSVktvgsss---------------neglmspKNL---LVTtvtdelrmatnfrSKVISVSIKDrg 174 Synechococcus elongat...
Q6N507 102 PPAGNTVvPFIENDDVLgd-------------------------idNHFdgnYLN-------------EESLLKLARDk- 142 Rhodopseudomonas palu...
Q47910 103 IQATGQN-MYCTQDDSVqavggeg---------------kvgqqspKNL---LVStitdqlklatnfqSKVIGIAIKDrg 163 Myroides odoratus
Q6A8W7 109 APSGRVMnALSWVNGDD-----------------------------PEV---IQP-------------HPTAFESLVAa- 142 Cutibacterium acnes
Q73VT6 112 VPGTDRVlNHVRWRDDPa----------------------------PDA---WQP-------------LPTWFERLAAa- 146 Mycobacterium avium s...
O50518 129 NPDTGALmNQLRWQPWTa----------------------------PGP---WQP-------------YPTVFGLAHAa- 163 Streptomyces coelicolor
5TOO_A 155 silpaGHN-PT---GAFWfddTTGKFITStyytkelpkwvndfnnkNVPAQLVANgwntllpinq---------ytesse 221 Elizabethkingia menin...
Q7MEK0 178 aislgGH--AG---KAFWfskATSEFVTSnyyydqtpqwvtqwnaeKIPAQYSGQkwsltlpq------------drytl 240 Vibrio vulnificus YJ016
Q84EY0 161 aialaGH--AG---KAFWfdtTNGGFIAStyyykqypqwvknwnknYHPQDYdwhlsrsk---------------seyqn 220 Fluoribacter gormanii
Q89ZL4 159 aifaaGHA-GN---GAFWinpTTGKWSGTtyygefpw-wasqyndrQAIDSRISSvtwepvfp------------rgmyt 221 Bacteroides thetaiota...
Q55320 175 ailpgGHT-AN---GAYWyddMTGSFISSthymqqlptwvndfnaqRLPNKYFEQdwntlypiet---------ytesta 241 Synechococcus elongat...
Q6N507 143 -----GLS-TA---AIGKl-gPTLLFDHTdradkpgphsividdatGSPKGAPLPddfkaeldklglplkppargenaka 212 Rhodopseudomonas palu...
Q47910 164 gilpaGHF-AN---AAYWldgKTGDWITStyymkdlpkwvkgfnkeKVVDQYYKQgwktlypidt---------yvlsta 230 Myroides odoratus
Q6A8W7 143 -----GVTvSSigpARFQ----RSGLTRAs----------------LRGPRFIpir------------------------ 173 Cutibacterium acnes
Q73VT6 147 -----GVRaRAvlpSSFL----GSGLTEAayr------------gaRLVPAEPAD------------------------- 180 Mycobacterium avium s...
O50518 164 -----GVH-AAqvsSPTFantPLTKVALSggef----------------------------------------------h 191 Streptomyces coelicolor
5TOO_A 222 dnvEWEGLLG-SKKTPTFpytdlakdyeakkglirttpfgntLTLQMADAAIdgnq--mgvdDITDFLTVNLASTDYVGH 298 Elizabethkingia menin...
Q7MEK0 241 qeiSQEHKVDlAGFARTFphpygpasfkyfstmltlspagdeITANFAQRVLekeq--lgkgDTTDYLAVSFSSNDYVIH 318 Vibrio vulnificus YJ016
Q84EY0 221 ansPVFHHED-ELFGQTFphhitqapspeyfkslsrtpkadqLTADFAEQLLtkerl-gqssGKTDYLGISFSGVDAIGH 298 Fluoribacter gormanii
Q89ZL4 222 flpDWRDVV--------Fkykfdddrnnkf-rrfitspfvndEVNALAEEAIgkgs--vgmdDITDLLALTYYAGNYAHK 290 Bacteroides thetaiota...
Q55320 242 dakPYERTFK-GAKTSSFphlfkqyankny-smmasmpqgnsFTLEFAKAAIpaek--lgqtGNTDFLAVSLSSTDYVGH 317 Synechococcus elongat...
Q6N507 213 gdaKTPGTLVaNVVQQAY------------------------FADVAAKAVLplf----kqrGKPFVLVFWSRDPDGSQH 264 Rhodopseudomonas palu...
Q47910 231 ddnLYEETFK-GEKTPTFprdlvklkkengyelikstpqgntLTLDFAKRAIeneqlgnnplQVTDFLAVSLSSTDYIGH 309 Myroides odoratus
Q6A8W7 174 dedDVDERVY-KTLK---------------------------ASRSGDA----------------SLTYVYERSLDHVGH 209 Cutibacterium acnes
Q73VT6 181 ---DYPRLVG-EELR-----------------------------------------------AGPGLVYGYTAELDTAAH 209 Mycobacterium avium s...
O50518 192 grlSGEDRMD-CAAEQ--------------------------LARADR-----------------ALVYTYYAEVDGAGH 227 Streptomyces coelicolor
5TOO_A 299 NFG-------PN--SIEVEDTYLRLDRDLADFFNNLDKKvgk-gnYLVFLSADHGAAHSvgfmqAH-KMP---TGFFVED 364 Elizabethkingia menin...
Q7MEK0 319 MYG-------PN--SLETEDNLIRLDRTLAKLFDAVDKQvgldntL-IVLSADHGVPEAspnarQI-GLR---QAQYFDQ 384 Vibrio vulnificus YJ016
Q84EY0 299 QFG-------PN--SLESEDNLSELDKTLAHLFAVIDKHvglnntL-IVLTAAHGVNDGpt--yLK-AHH---MDEINPI 362 Fluoribacter gormanii
Q89ZL4 291 SVQ-------EC--AMEIQDTYVRLDRSIANLLDLLDKKvgl-qnVLIFVTSTGYTDSEstdsgLY-KIP---TGEFHLN 356 Bacteroides thetaiota...
Q55320 318 QFG-------PN--SIELEDTYLRLDKDLEDFFNYLDKTigk-gnYLLFLTADHGATHVpgflrNK-MPG---GRLLLKV 383 Synechococcus elongat...
Q6N507 265 NQGdslneltPGinGPTSLAGIRNADNNLAQLRKALDELgls-asTNIIVSADHGFSTIskqskTSpSAKasyGDTPAGF 343 Rhodopseudomonas palu...
Q47910 310 QFA-------IN--SIEIEDTYLRLDRDIADFLAYLDQNigk-gnYTLFLSADHGAAHNpkffaDQ-KGNsgyFDTKAIR 378 Myroides odoratus
Q6A8W7 210 GEG-------WQ--SAAWRSRLMWVDELVGALLDELDPG------TALVVTADHGMVDIpd--dHR-------------- 258 Cutibacterium acnes
Q73VT6 210 LFG-------IG--SPQWHTAAAAVDALLSGLLEALPPN------AALLVTADHGGLNVppearVD-------LDSDPRL 267 Mycobacterium avium s...
O50518 228 RFG-------VD--SDTWRGQLGHVDRLVQRLAEQLPPR------SALYVTADHGMVDVpfdeeHR-IDF---DEDWELK 288 Streptomyces coelicolor
5TOO_A 365 Mk-----------kEMNAKLKQkfgadNIIAAAMNyqvyfdrkVLADSKLELDDV-----------RDYvmt-------- 414 Elizabethkingia menin...
Q7MEK0 385 Ktll-------stqIEQRLKQEfglskDAIRLYAQpyiylnheVIAKSKASLADV-----------QALiaeev------ 440 Vibrio vulnificus YJ016
Q84EY0 363 Nipqm-----eqyiRASLKSRYalpeqTLMSITPPnilslihkVINNHKIELNEV-----------KRYiahal------ 420 Fluoribacter gormanii
Q89ZL4 357 Rct----------aLLNMFLMAtygegKYVEAYHDqqiylnhkLLEQKQLNLTEV-----------QEKsadflmqfsgv 415 Bacteroides thetaiota...
Q55320 384 Qt-----------dLDSLIFNEfkvrcNFTIINNQvif--dtdAIKEAKADYAKI-----------KQStidyl------ 433 Synechococcus elongat...
Q6N507 344 LpmgflaidlakalKLPLFDPNngnapVGDNAHPKagngvlgkDPAKPDLVVATNggsdliylptgDKKlagrtiralle 423 Rhodopseudomonas palu...
Q47910 379 K-------------DLNEKLASkfgvaDLVKSLANyqvhlnyeVIEANDVEEDEV-----------IAAaikll------ 428 Myroides odoratus
Q6A8W7 259 --------------VMVEDEGGlladvALLAGEPRfr----hiYTRRPDEVAQRW-----------RRVl---------- 299 Cutibacterium acnes
Q73VT6 268 Aa-------------------------GIRVVAGEprvrylhtEPGAAPDVQAAW-----------SELld--------- 302 Mycobacterium avium s...
O50518 289 A--------------------------GVALLGGEgrarhvyaVPGARNDVLFCW-----------REVl---------- 321 Streptomyces coelicolor
5TOO_A 415 --elkKEpsVLYVLSTDeiwessIPepikS-RvingynwKRSGDIQIISKDGYLSAYSKKGT----------------TH 475 Elizabethkingia menin...
Q7MEK0 441 -skleGV--AYAITSSDiennrvVDsritK-LiknnyhpQRSGDIYLVFGARSYINDMDGLTia-------------sTH 503 Vibrio vulnificus YJ016
Q84EY0 421 -tlqpGIfkAYALPITD------IEkdwlSaKvnkmyfpNRSGDIYLIQPPNQSYGTKGKDRv---------------AH 478 Fluoribacter gormanii
Q89ZL4 416 neaysAHrlLLGSWTPEiy---rIRngyhR---------KRSGDLVIDVLPGWTIVSENGNEnk------------vvRH 471 Bacteroides thetaiota...
Q55320 434 -vkqdGV--LNAVDIKNmga-vtIPqeikN-KiingynaRRSGDVYIILDAGWYPTLTPGTG-----------------H 491 Synechococcus elongat...
Q6N507 424 qdyvsGL--FVDDSLGS------FPgalpL-SalnlkgkAATPTPAIVVNFRSYASGCAEPTvcsvqvadtvlrqgqgMH 494 Rhodopseudomonas palu...
Q47910 429 -kkvdGV--AFVVDMNEaae-ssVPqilrE-RiingynfKRSGAIQLILEPQWFSGSKDGKGt---------------TH 488 Myroides odoratus
Q6A8W7 300 -----GD--RAQVVIGDd----aVAad--lfGpvdvstrSRFGDVLAITRGDWAIMSRATPKelt----------lvgMH 356 Cutibacterium acnes
Q73VT6 303 --------gRAAVYSRVq----aVAtg--mfGpvadrhlPRLGDVVVVCSGDTAVLASAHEPpeta--------rlvgFH 360 Mycobacterium avium s...
O50518 322 -----GE--QFWVASRDe----aIAagwfG-PgiddrvyDRIGDVVAAARDDVLVIASEREPkesa---------mvgNH 380 Streptomyces coelicolor
5TOO_A 476 SVW 478 Elizabethkingia meningoseptica
Q7MEK0 504 GSP 506 Vibrio vulnificus YJ016
Q84EY0 479 GSP 481 Fluoribacter gormanii
Q89ZL4 472 SYi 474 Bacteroides thetaiotaomicron
Q55320 492 AAW 494 Synechococcus elongatus PCC 7942 = FACHB-805
Q6N507 495 GSF 497 Rhodopseudomonas palustris
Q47910 489 GSW 491 Myroides odoratus
Q6A8W7 357 GSL 359 Cutibacterium acnes
Q73VT6 361 GAA 363 Mycobacterium avium subsp. paratuberculosis
O50518 381 GSM 383 Streptomyces coelicolor
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