Conserved Protein Domain Family
DoH
?
smart00664: DoH 
Possible catecholamine-binding domain present in a variety of eukaryotic proteins.
A predominantly beta-sheet domain present as a regulatory N-terminal domain in dopamine beta-hydroxylase, mono-oxygenase X and SDR2. Its function remains unknown at present (Ponting, Human Molecular Genetics, in press).
Links
?
Statistics
?
PSSM-Id: 214768
Aligned: 41 rows
Threshold Bit Score: 74.7665
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q9VH23        292 HKDMQVSWEVFG--PQITFQLSGQVGG----ND-YMSFGISGSdvsSQMIGSDVVVAYIDD-----IRGYTVDYN--ITS 357  fruit fly
O45247        398 CDDIRSSWSLLSd-NQIHVELTGKVNAt---NK-YVAMGFSTN---GTMGNTSVIECSSFDn---sNFSMTFSYN--LVN 464  Caenorhabditi...
O45247        217 DGNIGASYQVISd-NQIAFEIFGPANTtvneNV-YVALGFSDD---EKMANISVIECSNLPs---eTAPTMKFSY--NPG 286  Caenorhabditi...
O45247        586 NNVDTVAYKVLNd-SYIEFEISSTQSSs--sGV-YTALGFSND---GKMNPANVIECSSLGsqplsMKFSTNSGY--SND 656  Caenorhabditi...
P90724         55 SIVTWRPVTTNTteTKIAIELRSSTe-----AG-YIALGFGRF---SQMKDADVYYCTSGGv---fGTAAMKAMH--APP 120  Botryllus sch...
Q18594         49 ECNFAFSSISNG--THTEIEIFGNSVId---KT-WLAIGYSAD---KKMEDDFVVFCIRDDa----GTNMNKLDQ--MAG 113  Caenorhabditi...
Q9SSF3         54 PQNFILRYARTAe-NTWSFILSAPDS-----SA-FIGIGFSTN---GQMIGSSAIVGWIPSd---gGSGTVKPYL--LGG 118  thale cress
Q9M363         63 WNTFVLRYSENR--DNVMTIIVSALYT----TG-WVGIGFSKE---GRMVGSSAMIGWISKk----GHAKIKQYY--LQG 126  thale cress
XP_002081701  247 SCTSITVVTVRG--DVFEFEIQSGKGT----NAaYVAVGLSDD---AKMGDDLTTEC-VPEn----GRVNLYSSL--TS- 309  Drosophila si...
NP_497005      38 SNGMGVAWSLLDd-ETLLLELFVNSDEe--kGR-YVAVGFSND---EHMgnepvie----csaignQKPSMKFSFdkTNG 106  nematode

Q9VH23        358 LAPCVqvlgqnkgvcRDDVVGGLDS----Fql-----nTYSRKDGINTISFRRTLKSSDDg----DKEIFLDRSNYVIWA 424  fruit fly
O45247        465 APDYSn---------LRSTSDVSGL----Ftn-----rRVQFVDGVLYCSADVAVVGDANdq--tVFKYDPATKYSIIMA 524  Caenorhabditi...
O45247        287 F--------------KNARIDGEPP----IrakfiqqsIGRISDGSIYCKGVVNVGGEAEnp--qIFKWNKNQGYHLMFA 346  Caenorhabditi...
O45247        657 RISGE----------EAIRSQYITN----T--------ETSYVDGKIYCKGTVRSDGNSNa---aIFKYTPKQQYHLIIA 711  Caenorhabditi...
P90724        121 DA-------------MPLENGMVLN-------------KISQVNARINCQFERRMSVTKPdsvneYDYDISKETFHILVA 174  Botryllus sch...
Q18594        114 LAYNGkhsnemtgtiENIKKNKNDK----Fgldl-emkEYEKDEQTLYCKMAHRVEPIID--------RFNVSKVEILMA 180  Caenorhabditi...
Q9SSF3        119 KSPGEv---------NPDQGDLTIVng---------slKIESVSSRLYMRFQLTATLPRQ-------SLLYAVGPAGFFP 173  thale cress
Q9M363        127 TERDQv---------VPDQGELQLQkv---------ppVVALHGAMIYLAFQVKFAVRVP-------RRAVILAFSTAYP 181  thale cress
XP_002081701  310 -ASPY----------SAVRSNVNQNsarlL--------DASIVDGVIYCRVQRDAVTNVQg----RTFDLRNGKYHLLVA 366  Drosophila si...
NP_497005     107 KGN------------ERIAGDYTAH----Fsn-----nTAVFENGVLYCKSNVKVSGSSEns--nVFKFDPSTQYHLLLA 163  nematode

Q9VH23        425 FGP---LDSNNEPAFHT-Yy--pKSDIVIDFNTTEP 454  fruit fly
O45247        525 TGDtstKGNVKGLGYHK-Kk---RSVAPLQLLSDYT 556  Caenorhabditis elegans
O45247        347 AGF----SADTGLTQHW-GscvsILTFLDQVNNLGF 377  Caenorhabditis elegans
O45247        712 KGT----ASPGGLGYHG-Tn---RYISTARLLTDLG 739  Caenorhabditis elegans
P90724        175 DG-----PFQDALQYHD-Wr--eVTDTKVNFTSKFG 202  Botryllus schlosseri
Q18594        181 KGT----WMKGGLSYHG-Nt--rNNTGIIDLSGESK 209  Caenorhabditis elegans
Q9SSF3        174 SS------PDFRLREHR-F----VTTTTINYNTGSQ 198  thale cress
Q9M363        182 SK-------LGRLTKHD-D----KTTVIVDFSKASG 205  thale cress
XP_002081701  367 SGS---SLKENSVGYHDiGr--lPSAQPINLAEVQD 397  Drosophila simulans
NP_497005     164 NGK----TTAKGLGYHK-Dq--sSVSRKLRLSESSP 192  nematode
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap