Conserved Protein Domain Family
7TM_GPCR_Srz
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pfam10325: 7TM_GPCR_Srz 
Serpentine type 7TM GPCR chemoreceptor Srz
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.
Links
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Statistics
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PSSM-Id: 431214
Aligned: 54 rows
Threshold Bit Score: 144.27
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O45618  28 VLIFIILFLFYILVFPFYVYVNKVNKERDKNAFVFPITNHFFEM---TKNAFIGYIYFPVNCFFAVALIYkk-----sfF 99  Caenorhabditis elegans
O62051  25 LVIFLIIVICFLTIFPFYVYVNKKNQNSDKTALLFPMTNHFYEM---IRKTYFIFVYFFGALISMPMLEGs-------nY 94  Caenorhabditis elegans
O45615  25 YGILITGFFLNLLIFPFYMYVYKKNKENDGTTPLSPVTNHFYKM---VRTVYALPMCSIVIYILKTFIAVen-----pvI 96  Caenorhabditis elegans
Q65CL7  26 RVIDYGTIIIFFAIFPFYVYVHKINDVKDREALVFPITNHFYKT---VVLMIIGYVIVVLLVLFLATNSIls------yI 96  Caenorhabditis elegans
O45642  26 SEIQYIAVVCQLIVFPFYVYVHKANNIRDREVVVFQITNHFYKCvvaMNIGYVLFGIFVLCTLAEGLLIY---------I 96  Caenorhabditis elegans
Q9TYW8  26 ISTLVCILCCYIVLFPFYVYVNKVNRKRDEAAFIFPITNHFYKM---VKTSYIIFTCGLLLVLFGFSLDIdfndasifsL 102 Caenorhabditis elegans
Q5WRL4  11 SITNCVFMVISFLIYPFFVAVFRKNHAKDKGKAIFPVFNHFYKSikkIQIVNAIYILYFFFTLFMAFFGAt-------fF 83  Caenorhabditis elegans
Q93869  28 GIPLIFLWFCYLSIFPFFLAVFHLNKEKEKETAVYHIIYYFVVT---VKRMYALQLFQLTIFPAIAYFETy-------wI 97  Caenorhabditis elegans
Q86D22  28 ALLGGICAIVFCVIFPFYIVVYRTNRQRERSTPIFPIIKHIHST---VVRTYFLLFGCFVIIIISFALSSm--------L 96  Caenorhabditis elegans
O17926  28 AVLVGTCSIVFCFIFPFYIVVFRSNRQRDRSTPIFPIIKHFYST---VVRTYILHFGFYVIVIICFALNSs-------tL 97  Caenorhabditis elegans

O45618 100 VVPFLIVMVIIIFCLHVITQIFYLLIIVLAFERFLLYFLKSTERTLQIIQTFIhrHFNSFYAIFAIKDALYIISWLVSSG 179 Caenorhabditis elegans
O62051  95 ATGSLIFLIGSYFALYIIVQVFHLLIFLLALQRFLLYYYPSTGKHVKSVQMIIfkKIKYIYAVFAMKEVICLCIFVVCNS 174 Caenorhabditis elegans
O45615  97 GDLLMDIIYVFLYIMYLIIQVYHLLIFLLAVGRFLLYFFPKTKETVLSAQNILqrKVKYIYALFIVKDFIFLLCLEIGNS 176 Caenorhabditis elegans
Q65CL7  97 GFLSLPAWALVIVTYHLIVEVFHVLISLLAIEKFLIYFFPSWEKNVLIVQKFVqkYILLLYLGCCLK---YALLYALESW 173 Caenorhabditis elegans
O45642  97 SLIIFPIGIVYVFIEMIIADVFHLLISLLAMEKFFIYFFPRWEKTVISIQKYIhkYIVFVYLACCSR---YMLSAVIGSS 173 Caenorhabditis elegans
Q9TYW8 103 KSIFLMLLFLITCILYVISEVFNYLISILALEKFIVYFSPRAEHFVKRVQNVQmkFIKCFYLAIGVKELVVNTSMLLMNK 182 Caenorhabditis elegans
Q5WRL4  84 VFLIPVLLIVFPLVTGLMHDVNEFLLGLLSIQRFCLYFMPNYEKYLNISVEALnvVVRNLYICFIIKSVMLIILPYIYT- 162 Caenorhabditis elegans
Q93869  98 QVVILIMYPPTGWILTLTNRVNQSFMGILAIQRFTLYFYPSSEKYVKITPTTLqwIIFIEYLYFLAEPLLLVYFAHISNL 177 Caenorhabditis elegans
Q86D22  97 LILVFLIAILSAAYLVMVSKVNHLLMGILAIQRFGICFHPRSENYLKITHETLnwIVAIGYAYFVLEKVVSFWMYFCEF- 175 Caenorhabditis elegans
O17926  98 FILVFLFLILWAAHLTMSNKVNQLLMGILAIQRFCICFHPRSENYLKITHGTLnwIVFIGYAYFLLEKVIFFLMCLRDF- 176 Caenorhabditis elegans

O45618 180 NYQ-----FWLEFSYMTVYFATLIFIFTSAFFYIPIMISVRKLTN-LT-SAKQSNPEKYIFWQTIVIFICKSIAIPIIVD 252 Caenorhabditis elegans
O62051 175 IGCsgrkkLLAEMVYFSTFSVLNLLILIASFLYLPITISIHKLSR-LStNQERNKPQKYILWQTIFIFLSKAVFIPAFIV 253 Caenorhabditis elegans
O45615 177 IGSkr-rvELAKNCYAAIFFSINLLIIISAILYIPIVRSVGKLAI-VL-SAKQSKPQKYILWQTMIVFIFKMVTSFVFID 253 Caenorhabditis elegans
Q65CL7 174 FGGg----RGWELSYGISYYSLYILLFISVLLYIPVIISVRKLSH-LQ-SAQLNNPQRYIMIQIIVVFIVKIVNIIPRSF 247 Caenorhabditis elegans
O45642 174 LEP-----YGWKFLGPIVQHFLTIILFISVLLYIPVIISVRKLSH-LQ-SAQLSNPQQYIMGQIIVVFFFKIL---MFIP 243 Caenorhabditis elegans
Q9TYW8 183 NGVadirkSNEAIVLAITLGSTSALIFFSALLYIPITISVRRLAH-LP-SVKQSSPQKYIFWQTITVFIFKSFLIATALY 260 Caenorhabditis elegans
Q5WRL4 163 --------ANILTYTTLILLFQNLFVFLCALLYIPILISIRKARH-LS-SFKLHRPQNYIMYQLLLALFAKCIYAIHIFQ 232 Caenorhabditis elegans
Q93869 178 KHLn----YQIDMYF---FFGEHIFLILSNSLYVPIIISIRKLTH-LT-SAQQNKPQKFIMCQCLLIVVEKIIFGICIFF 248 Caenorhabditis elegans
Q86D22 176 --------EDVKVFYMFSYISMHLFLLISALAYIPLILNIWKTSKhLK-SAQLHKLQNHIMCQFLLIIASKFIYIPIFLF 246 Caenorhabditis elegans
O17926 177 --------EAAKVFYMFSYISMHLFLLISALTYILLILNIWKKSKhLT-SAKLNKPQNYIMCQFLLIIASKFINIPIFFF 247 Caenorhabditis elegans

O45618 253 FFI---HSESTIGVlvdFLIISDLVTTPLIIQLSYLGCNK 289 Caenorhabditis elegans
O62051 254 LA----LPSTDFVNslvLMVVTDVLVVPLIIQISYLCCNK 289 Caenorhabditis elegans
O45615 254 FFL---DKAAVTFElipYIILTDIVITPLIIQISYLGFNK 290 Caenorhabditis elegans
Q65CL7 248 VAFlykDPLYQILI---VPSLSDIVAVPLIVQVSYLGSNK 284 Caenorhabditis elegans
O45642 244 DSVhifLKEGTLHSv-lMVSTNDSTTIPLIAQLSYLGCNK 282 Caenorhabditis elegans
Q9TYW8 261 LFH---NGQGIVSEl-iLILVVDVIITPVIIQISYLGCNK 296 Caenorhabditis elegans
Q5WRL4 233 SPLhelNEVIL------KYQYLDICHVSFFPQISYLLCNK 266 Caenorhabditis elegans
Q93869 249 KLSseyHTMKA------ISTTRDMYVSIFVIQLSYILCNK 282 Caenorhabditis elegans
Q86D22 247 NGDw--FA---------VNEALDGYISIFLIQASYLVCNH 275 Caenorhabditis elegans
O17926 248 NRDw--FA---------FNEGLDGYISIFLIQVSYLVCNH 276 Caenorhabditis elegans
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