2I2R


Conserved Protein Domain Family
BTB_2

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pfam02214: BTB_2 
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BTB/POZ domain
In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.
Statistics
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PSSM-Id: 426665
Aligned: 34 rows
Threshold Bit Score: 95.7355
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2I2R_B  43 IVLNVSGRRFQTWRTTLErYPDTLLGSTEKe--FFFNEDTKEYFFDRDPEVFRCVLNFYRT---GKLHYPrYECISAYDD 117 Norway rat
Q18986   7 VKLDVGGKIFKTTIFTLC-KHDSMLKTMFCtdvPVTKNEEGSVFIDRDSKHFRLILNFLRDg-qIALPDS-DREVREVLA 83  Caenorhabditis elegans
O70479  30 VQLNVGGSLYYTTVRALTr-HDTMLKAMFSgrmEVLTDKEGWILIDRCGKHFGTILNYLRDd-tITLPQS-RQEIQELMA 106 house mouse
O16706   5 VQLDVGGTIFKTSKSTLT-KFNGFLKIMLEsdiGLKIDESGSIFIDRSPKHFDLILNFMRDg-dVVLPSC-ELTVKELLA 81  Caenorhabditis elegans
P91564   5 IKLDVGGTIFKTSKDTLTk-FHSFFKTMLEcktGPKIEKTGCIFIDRSPKHFELILNLMRDg-dLPLPED-ERELRELMA 81  Caenorhabditis elegans
O16711   8 IRLNIGGTIFETSKSTLTk-FDGFFKTLLEtdiPIQKDDSNCIFIDRSPRHFEKILNYLRDgadVDLLPEsEKEVREILK 86  Caenorhabditis elegans
O16612   6 VKLNVGGTVFETLKSTLTk-HDGFFKALIEtdvPAEKDDSNCFFIDRSPKHFETVLNYMRSg-dVVLPDS-KKDMLELKK 82  Caenorhabditis elegans
O16613   8 VKLNVGGTVFVTLKSTLTk-HHGIFKALVKtemPAEDGDS--FFIDRSPKHFETVLNYIRSg-dVDLPDS-ENELKELKR 82  Caenorhabditis elegans
O16708  99 VNLNVGGKPFATLKTTLQ-KFEGNLKELPEi--QGESLPTARIFIDRPYKHFETILNFLRDg-dVILPES-MESLKELLH 173 Caenorhabditis elegans
O16630   2 IRLDVGGRKFSTNRSTLTk-FDGYFRKLPKlkdESSTTTR--IVIDRSPKHFETVLNFMRDg-sVDLPES-LKHLRQLLR 76  Caenorhabditis elegans
2I2R_B 118 ELAFYGILPEiIGDC 132 Norway rat
Q18986  84 EASYFLLDPL-IELC 97  Caenorhabditis elegans
O70479 107 EAKYYLIQGL-VSTC 120 house mouse
O16706  82 EAQFYLLDEL-IELC 95  Caenorhabditis elegans
P91564  82 EAQFYWLDGL-VLMC 95  Caenorhabditis elegans
O16711  87 EAQFYLLEGL-MELC 100 Caenorhabditis elegans
O16612  83 EAEYYLLSNL-AKLC 96  Caenorhabditis elegans
O16613  83 EAEYYSLEKL-ATLC 96  Caenorhabditis elegans
O16708 174 EAILYKLSGL-SEKC 187 Caenorhabditis elegans
O16630  77 EAIFYGLEKL-IECC 90  Caenorhabditis elegans
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