Conserved Protein Domain Family
CEP19

?
pfam14933: CEP19 
CEP19-like protein
This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.
Statistics
?
PSSM-Id: 373400
Aligned: 16 rows
Threshold Bit Score: 144.389
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q389Q9       186 KSIGLRVQPVEILIFYTY-----NGRPRRRFIPLdGLLHENSPIAPLLRRLVRShgmlvseSQLRSYLQRLQELMRKsve 260 Trypanosoma brucei
EDV24154       5 KHCGIRYSPPTLVIFYISd---eTGSTHRRSMPI-RGINSSSNSEDLLDQLMQR-------SKNSYYLSKISKSQLK--- 70 
XP_002435860  10 KKIGIRFKGPALIVVYETp----SGKLHQRTMPI-RDMSKNSNVRNVAESLRDR---------HAAIFGSASLVQVE--- 72 
XP_002593462   8 RKCGIRFDPPALFVTYTDk---sAGKTRCRTMPI-RNFTKTSTVTRFVEDFRKN-------PRHKKYLEDVPKSQLE--- 73 
Q4V8Z3         6 KRCGVKFTPPSIIIIYENk---tSGKMRKRVIPV-RNFSQYSDCSRAAERLKHH-------VRHSVYLECVSLAQLE--- 71  zebrafish
EEB10572       6 VKCGIRVEPPGLVIVYKTn---dEKKLKRKIIPL-KKYTPFVDVDVTFEKLRQR-----------NDLKQIPSIKIK--- 67 
EFX79849      19 RKIGLKLDPLSLILLYQDg----EVKVRKRFMPI-RNLKSQADPWARAEELKLR---------HMTYLAAVPTVILT--- 81 
XP_001633900   5 KKFGVKYEPPTLVLFYVDk---aTDKLHRRSIPV-RKFDGDSSIQNTANELKKS-------SHHGKFIEGIPQKQIE--- 70 
EFC50786      11 LRIGIRLKLCALVIEYTTiskkgKKELRHRKIYL-EDYIVQNYPELEEDELVEHiksnvlmKHHKNLASHIPENQTT--- 86 
XP_001567783 177 TRMGVRSMPPTLYIEYERp----AGVSRVRCIHLrANLRPNMPTAQLARRLATTheallseAQFQSLLIRCQRLQGQipv 252
Q389Q9       261 shastvKPEGPLqpqfdwkqqigysdnapaahnTGEEEQHMTSAKTGEPEVNKADVGllyrd-peaalKNVDLNDADDIT 339 Trypanosoma brucei
EDV24154      71 ------RLIGKLin-----------------hlTLAEEPETEINSNDNAIKEDNPFKrastt-vdekvLNEDFNKVDEVE 126
XP_002435860  73 ------KMLRLA----------------------QESMKGKSLDECLEIVAKEFTLN-----------PEEDLNKVDDDT 113
XP_002593462  74 ------KLLRLL----------------------QDNLRGMSLDQSLNEIRKEYSID-----------PNEDLNKVDEET 114
Q4V8Z3        72 ------RLHLLL----------------------RDHLQGASLEESLAAHRHQE--------------EEEDLNKLSDEE 109 zebrafish
EEB10572      68 ------KMIRLL---------------------QEITINGKTMEEGVEIIKNDYELK-----------LNENLNKLSTKE 109
EFX79849      82 ------KLISIA----------------------QQVMIGLDVDEAVRQVTQRFSVD-----------VERDLNVVSEPE 122
XP_001633900  71 ------KLLKLI----------------------QDKIKGLEPKPNPTENKPAAQLD-----------PDKNLNKLGDDE 111
EFC50786      87 ------KMIRKLvdfttksfl---ppdnrpqsiQNQSKPSPNTNNTTSKYHHQGDDDnfdedeedsetQQKDLNKLDDVT 157
XP_001567783 253 ssaataPPTGTGvqasm-----------valpsTTADSPSPSALTARSSKPQKADLGllyrd-pdaalENVDLNDADDVT 320
Q389Q9       340 LQEFKAKMNEGFMQNALRPGDPGYVYDKRLDVNPTE---RSEWD 380 Trypanosoma brucei
EDV24154     127 LDRIKKKMDVSFEANRIKPGDDTFQYDLDVEFERVDv-dACSWD 169
XP_002435860 114 LQRKKDLMNLTFEKNCKKPGDPDFKYDVEEDFDLEGaieTSGWD 157
XP_002593462 115 LRKKKTAMEDSFEKNRKKPGDPDFEYEVERDFQPVE---TCEWD 155
Q4V8Z3       110 LSRRKAQMDDLFQRNRRRRGDPDFVYDLEVEFGEGSvkeTCSWD 153 zebrafish
EEB10572     110 LNVQKELMDTLFIKNQIKKDDVDFVYDKRIQFSGEKi--NSDWD 151
EFX79849     123 LKRQKELMELTFISNVIGPSDPRFVYDKQVAFHRPDr--VSDWD 164
XP_001633900 112 LNKVKAAMDIDFEKNRIRPGDEDFEYDKEVDFGDAGk-iESGWD 154
EFC50786     158 LRRVKAEMDKKF--NVIRPGDEGYEYDKEVDFENVPk-qQSSWD 198
XP_001567783 321 LQEFKEVMNERFKANVVRPGDPGYIYDKRVAVAKAAq--KSEWD 362
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap