1NUN


Conserved Protein Domain Family
beta-trefoil_FGF10
?
cd23320: beta-trefoil_FGF10 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 10 (FGF10) and similar proteins
FGF10 plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. It is required for normal branching morphogenesis. It may play a role in wound healing. FGF10 interacts with fibroblast growth factor receptors FGFR1 and FGFR2, as well as fibroblast growth factor-binding protein 1 (FGFBP1). FGF10 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
?
Statistics
?
PSSM-Id: 467006
Aligned: 6 rows
Threshold Bit Score: 261.016
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
heterodimer
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NUN; Homo sapiens FGF10 in complex with FGFR2b, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1        #######    # #   #            # #        ######  #         #              #     
1NUN_A         9 HLQGDVRWRKLFSFTKYFLKIEKnGKVSGTKKEnCPYSILEITSVEIGVVAVKAInSNYYLAMNKKGKLYGSKEFNnDCK 88  human
XP_007890403  60 YLEGDVRWRKLFSFTKYFLKIDSnGKVGGTKKEnCPFSILKITSVDVGVVAIKAInSNYYLAMNKKGKIYGSKEFNiDCK 139 elephant shark
6015141       72 HLQGDVRWRKLFSFTKYFLKIEKnGKVSGTKKEnCPYSILEITSVEIGVVAVKAInSNYYLAMNKKGKLYGSKEFNnDCK 151 human
NP_001131038 112 HLQGDVRSRKLFSYTKYFLQIDGnGTVSGTKREnCPYSILEITSVDVGVVAVKAInSNYYLAMNRRGKIYGSKVFNiDCK 191 African clawed ...
NP_990027     76 HLQGDVRKRKLYSYNKYFLKIEKnGKVSGTKKEnCPFSILEITSVEIGVVAVKSIkSNYYLAMNKKGKVYGSKEFNsDCK 155 chicken
XP_006005973  62 HLQGDARRRKLFSFSKYFLNIDKnGRVSGTKKEnSIYNILEITSVEVGVVAIKAIhSEYFLAMNYKGKTYGSKEFNdDCK 141 coelacanth

Feature 1          ###  ####                                       # # 
1NUN_A        89 LKERIEENGYNTYASFNWQHngrQMYVALNGKGAPRRGQKTRRKNtSAHFLPMV 142 human
XP_007890403 140 LKERIEENGYNTYSSMKWKHnerQMFVALNGKGSPRRGHKTRRKHpSAHFLPIV 193 elephant shark
6015141      152 LKERIEENGYNTYASFNWQHngrQMYVALNGKGAPRRGQKTRRKNtSAHFLPMV 205 human
NP_001131038 192 LKERIEENGYNTYASHNWKNnerQMFVALNGKGVPKRGPKTRRKNtSAHFLPIV 245 African clawed frog
NP_990027    156 LKERIEENGYNTYASLNWKHngrQMFVALNGRGATKRGQKTRRKNtSAHFLPMV 209 chicken
XP_006005973 142 LKERIEENGYNTYASLKWKHkgkQMFVALNGKGAPKRGSKTRRKHiSAHFLPMV 195 coelacanth

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap