2O70,3O7I


Conserved Protein Domain Family
OHCU_decarbox

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pfam09349: OHCU_decarbox 
OHCU decarboxylase
The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyze the conversion of OHCU into S(+)-allantoin. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalyzed by urate oxidase (pfam01014) and step two is catalyzed by HIUases (pfam00576).
Statistics
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PSSM-Id: 462765
Aligned: 244 rows
Threshold Bit Score: 97.9817
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2O70_B               7 NALAYEDFVKLFGNVVEKCPLISAAIWSYrPFKDLADIEARISEFIHSLPDSGKEGILRCHPDLAGrdLQSGTLTPESQE 86  zebrafish
BGI:SBI_04707       14 NAASAGAAEDVLLACCGSRRWARLLVAHR-PYPDLDALLAAGDEASYDLTPADLDEALADEAVVGQ---LAAAIPMDGAG 89 
jgi:Srot_3065       11 NELNKPALLRVLLEVCQSPAWRNDLCDNR-PYPDVDSLLESSDKFLADITEIELEESLINHPRIGA--K---NAGPRSAR 84 
WP_005515771        13 NELPRRRAVHALFECCCCLSWSTRIADGR-EYRTYTELLAAADAELHALSEPEIEQALQGHPRIGS--R---ARSRPSFR 86  Rhodococcus
jgi:Srot_0394       11 NALEPKSAVSALFECCHCVVLAERLAKAR-PYASRSDLFSLADHELFRVDEETLGQIVASHPGVGS--R---PKSKASEG 84 
WP_005064897        13 NQMPDTRAVHALYECCGSVTWARKVAATR-PFADHDALFRCADNELFALSEESLNEMLTAYPPLGK--R---PGSVRSHA 86  Terrabact...
AHC27621            11 NALPERKAVHALYECCNSYVLARELVRGR-PYPDHDALFRRADAALFELPESAVDQILDACPDIGR--R---PRSAKSQA 84 
jgi:Mvan_5382       12 NALPMRRAVHAVFECCYSVPLAADLARAR-PFDTHDRLFRFADTLLFGLSEESIDSILQAYPDVGK--R---PGSEKSQA 85 
tigr:MSMEG_6116     13 NALPLRRAVHAVFECCCCVTLATDLAKGR-PYPDHASLFAKADELLFSLGEASMDTILQAYPCVGS--R---PHSEKSRG 86 
CeBiTec:CGLY_12770  14 NRMTPTQVADMIGDLLYSPQLGAAIAAAA-PFRSLEHVLDAAHRELLRLPRVEILASIQAHPVLGE--K---TTDSYSRE 87 
2O70_B              87 EQSQAGmtTLDSAEIVHMYRLNSEYKERFGFPFVICARLN-NKa---DIVRQLSERLKNrRTAELECAIEEVKKICSLRL 162 zebrafish
BGI:SBI_04707       90 ARAAL----------TALRAAHTEYERRFGHVFVICLDGLhPDemrnRVLAEIHARLDNeRDAERVKAAEELRRIARGRL 159
jgi:Srot_3065       85 EQSRFAs-TIDEAAFAEFAALNQQYEDKFGYLFLIAAEGRsAA----EIMDVLKGRLKNdVATERGVMRVELAKINRLRL 159
WP_005515771        87 EQCAVW--VEDAAVMHTLEDAAAAYEELFGFRYVWFSDGRdGR----ALLADLTARMTHdVDTERKVRTTELARITRTRL 160 Rhodococcus
jgi:Srot_0394       85 EQCAIW--DQDHAVMSRLHAVVGQYEAHFNRPFLIYAGELsAG----EVIAVAEQRLHNdEETEGKVVRNELAKVHRHRL 158
WP_005064897        87 EQCAIR--DETPGMMAALRAAAHRYEHHFGHRFVMHMCGQdGA----SVLRAISDRMHHdADTERKVTRNELAKINRTRL 160 Terrabact...
AHC27621            85 EPCAVW--DDDAELMAALSAASRQYAQRYGFTFVMFVDGHcAR----DVLAAVTDRMHHdIETERKILRNELAKIGRSRL 158
jgi:Mvan_5382       86 EQCAIV--DDRPEMMAELAAASKKYLDHFGFGFVMFINGYcAD----DVLASMHDRMHNdYETERKVVRNELARINRTRL 159
tigr:MSMEG_6116     87 EQCAVW--DADATVMAQLDEAARRYCERFGFGFVMYVGDScAR----DVLAAMDLRLHNdHETERKVVRNELSRINRARL 160
CeBiTec:CGLY_12770  88 EQSFIL--DSPPEVLVEIADLCQRYEARFHHIFLVCAQGIgGH----EVLLLLKRRLENpTVTEWETTVRELGRINVLRL 161
2O70_B             163 H 163 zebrafish
BGI:SBI_04707      160 A 160
jgi:Srot_3065      160 Q 160
WP_005515771       161 E 161 Rhodococcus
jgi:Srot_0394      159 E 159
WP_005064897       161 E 161 Terrabacteria group
AHC27621           159 E 159
jgi:Mvan_5382      160 E 160
tigr:MSMEG_6116    161 E 161
CeBiTec:CGLY_12770 162 R 162
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