Conserved Protein Domain Family
NDFIP1
?
cd22305: NDFIP1 
NEDD4 family-interacting protein 1
The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP1 has been shown to play a role in a variety of processes, including inflammation, immune signaling, and nuclear trafficking.
Links
?
Statistics
?
PSSM-Id: 412069
Aligned: 7 rows
Threshold Bit Score: 363.093
Created: 8-Jul-2020
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
 
PPxY motif
Feature 1: PPxY motif, 6 residue positions
Conserved feature residue pattern:P P Y P P YClick to see conserved feature residue pattern help
Evidence:
  • Comment:PPxY motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                ## #                     ## #                           
NP_001027505   6 SSRYQQLQNEEEPGEnpq-astDAPPPYSSIAGESSGLFDYKDElgFPKPPSYNVATSLPSYDEAERTKAEATIPLVPGR 84  Xenopus tropicalis
XP_007900176  37 SNRYQALQNEEEPVEvsesvaeAAPPPYSSIAADSAAFFDYKEDssFPKPPSYSVATSLPTYDEAERTKVEATLPLVSGR 116 Callorhinchus m...
XP_414658      8 SGRYQQLQNEEEPGEaap-vvsDAPPPYSSISAENTAYFDYKDEsgFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGR 86  Gallus gallus
NP_001086285   7 SSRYQQLQNEEEPGEnaq-asaDAPPPYSSIAGESSGLFDYKDElgFPKPPSYNVATTLPSYDEAERSKAEATIPLVPGR 85  Xenopus laevis
Q9BT67        16 GSRYQQLQNEEESGEpeq-aagDAPPPYSSISAESAAYFDYKDEsgFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGR 94  Homo sapiens
NP_955960      5 RSGYQQLTNEEESAEgfq-qtaDAPPPYSSLGASNAAFFEYKEDevYPKPPSYNVATSLPSYDEAERSKAEATVPLVTDR 83  Danio rerio
XP_006003274   5 NNGYQQLQNEEEPGEssq-aitDAPPPYSSIAGENAAYFDYKEEsgFPKPPSYNVATSLPSYDEAERTKVEATIPLVSGR 83  Latimeria chalu...

Feature 1                                                                                        
NP_001027505  85 DDDFVARDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTSSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYF 164 Xenopus tropicalis
XP_007900176 117 DDDFSGRDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYF 196 Callorhinchus m...
XP_414658     87 EEDFVTRDDFDDSDQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYF 166 Gallus gallus
NP_001086285  86 DDDFVARDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTSSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYF 165 Xenopus laevis
Q9BT67        95 DEDFVGRDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYF 174 Homo sapiens
NP_955960     84 DEDFIARDSFEDTDQLRVGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLVKWVLIVRFSTYFPGYF 163 Danio rerio
XP_006003274  84 DDDFVARDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYF 163 Latimeria chalu...

Feature 1                                                        
NP_001027505 165 DGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPDnf-sTLPRTRVLFIY 211 Xenopus tropicalis
XP_007900176 197 DGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPDtf-aSLPRTRVLFIY 243 Callorhinchus milii
XP_414658    167 DGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPDtf-sTLPRTRVLFIY 213 Gallus gallus
NP_001086285 166 DGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPDnf-sTLPRTRVLFIY 212 Xenopus laevis
Q9BT67       175 DGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPEtf-sNLPRTRVLFIY 221 Homo sapiens
NP_955960    164 DGQYWLWWVFLVVGFLLFFRGFVNYSRDRNMADhsmsTLPRTRVLFIY 211 Danio rerio
XP_006003274 164 DGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPDtf-sTLPRTRVLFIY 210 Latimeria chalumnae

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap