Conserved Protein Domain Family
7tm_7

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pfam08395: 7tm_7 
7tm Chemosensory receptor
This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family.
Statistics
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PSSM-Id: 462463
Aligned: 75 rows
Threshold Bit Score: 85.1479
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IPU5  37 LGILYSLTRVFG--LMATanwsprGIKRVRQSLYL-RIHGCVMLIFVGCFSPFAFWCIF-----QRMAFLRQNRILLMIG 108 fruit fly
Q9VYZ2  11 LRFWMGLILVLGfsSHYY------NPTRRRLVYSR-ILQTYDWLLMVINLGAFYLYYRYam-tyFLEGMFRRQGFVNQVS 82  fruit fly
Q9VEU0  10 LCLLLKYWQILA--LAPFr----tSEPMVARCQRW-MTLIAVFRWLLLTSMAPFVLWKsa--amYEATNVRHSMVFKTIA 80  fruit fly
O18280  46 LGPLYSYMMVLG--LNHT------HSSARNTMFKW-PLTIYNYLTLAILTAATIRRISQik-qkSATNEEKDAAFHVLNP 115 Caenorhabditis elegans
Q17990  48 LYPIYYLLLILG--LNQSir---pNNSLLFRIYSW-LVFCLLLFTTLRKFNQVGVRPNGtr-enLQEFFANPRSMITLCN 120 Caenorhabditis elegans
Q9VB26  12 AFPYLDIFSVFA--LTPPpq---sFGHTPHRRLRWyLMTGYVFYATAILATVFIVSYFNiiaidEEVLEYNVSDFTRVMG 86  fruit fly
Q8IMN6  14 ARPYLQVLSLFG--LTPPaef-ftRTLRKRRRFCW-MAGYSLYLIAILLMVFYEFHANIvs-lhLEIYKFHVEDFSKVMG 88  fruit fly
Q8IN22  11 LRFMSFYARFLS--LVCFrlr-kqKDNNVWLEEIWsNRSRWKWISVTLRIVPLCIYAFTya-ewISNRMLITEKFLHSCS 86  fruit fly
Q8IN23  24 LRSCFLYGTFFG--VITF------RIERKDSQLVAiNRRGYLWICLVIRLLASCFYGYSyd-awSGQYE---DMYLRAFF 91  fruit fly
Q9VD74  18 LFCSCHYGRILG--VICFdigqrtSDDSLVVRNRHqFKWFCLSCRLISVTAVCCFCAPY--------VADIEDPYERLLQ 87  fruit fly
Q8IPU5 109 FNRYVLLLVCAFMTLWIHCFKQAEIIGCLNRLLKCRRRLRRLMHTRKLk---DSMDCLATKGHLLEVVVLLSSYLlsmaq 185 fruit fly
Q9VYZ2  83 TCNVFQQLLMAVTGTWLHFLFERHVCQTYNELSRILKHDLKLKEHSRF----YCLAFLAKVYNFFHNFNFALSAImh--- 155 fruit fly
Q9VEU0  81 LATMTGDVCISLALLGNHLWNRRELANLVNDLARLHRRRRL-----------SWWSTLFLWLKLLLSLYDLLCSVpf--- 146 fruit fly
O18280 116 TFVLTLCHALLMFSGLAAGFLLLKLQKQREKMYHVLDQGLGRNRNEEHd--sHHFKLNKLFISISFSFAAALSFVqia-t 192 Caenorhabditis elegans
Q17990 121 ALIMLSGLLASLQLYTLGAKRLKPLKILCQ--FSLNVRTKQAERRQ------FMINTFLAVFSGLLALTMAATYAmsk-- 190 Caenorhabditis elegans
Q9VB26  87 NIQKSLYSIMAIANHLNMLINYRRLGGIYKDIADLEMDMDEASQCFGGq--rQRFSFRFRMALCVGVWMILMVGSmp--- 161 fruit fly
Q8IMN6  89 RTQKFLIVAIATCNQLNILLNYGRLGLIYDEIANLDLGIDKSSKNFCGk--sHWWSFRLRLTLSIGLWMVIIIGVip--- 163 fruit fly
Q8IN22  87 LVVSIPCYLSIIHLKICHGPEVTKLVNQYLHIFRLGTLDIRRRSQFGG----GRELFLLILSVCCQIHEYVFILV----- 157 fruit fly
Q8IN23  92 GFRLIGCLICSVIILVMQFWFGEELINLVNRFLQLFRRMQSLTNSPKN----RFGDRAEFLLMFSKVFSLLFVFMa---- 163 fruit fly
Q9VD74  88 CFRLSASLICGICIIVVQVCYEKELLRMIISFLRLFRRVRRLSSLKRIgfggKREFFLLLFKFICLVYELYSEIC----- 162 fruit fly
Q8IPU5 186 piQILKDDPEVRRNFMYACSLVFVSvcqailQLSLGMYTMAILFLG-HLVRHSNLllakiladaehifessqkagfwPNR 264 fruit fly
Q9VYZ2 156 -wGLRPFNVWDLLANLYFVYNSLAR------DAILVAYVLLLLNLS-EALRLNGQ----------------------QEH 205 fruit fly
Q9VEU0 147 lkGAGGRLPWSQLVAYGVQLYFQHVa-----SVYGNGIFGGILLML-ECYNQLE-----------------------REE 197 fruit fly
O18280 193 kmRYLDLPDTPDLINRKIYFVILEGy----vIFIASSCISLVAILFfQLCRILQFsigqlieem----vpkekeecpLPE 264 Caenorhabditis elegans
Q17990 191 wgYILYIVGTPNLDTETIFCVLLDSya---lFVSRAAISALAILFY-QHCSVIRRsikhlinem----vpaeqdecpLPE 262 Caenorhabditis elegans
Q9VB26 162 -rLTMTAMGPFVSTLLKILTEFVMIm----qQLKSLEYCVFVLIIY-ELVLRLRRtlsqlqeef-----qdceqqdmLQA 230 fruit fly
Q8IMN6 164 rlTLGRAGPFFHWVNQVLTQIILIMl-----QLKGPEYCLFVLLVY-ELILRTRHvleqlkdd------ledfdcgaRIQ 231 fruit fly
Q8IN22 158 ---IASRLCGFQHIIWWVSYTYVFI---------ICNSIMCFGFIWhLSLGVLYAelndnlrf------esgfqtafLRK 219 fruit fly
Q8IN23 164 --FRLMLSPWFLLTLVCDLYTSVGTgm---iTHLCFVGYLSIGVLYrDLNNYVDCqlraqlrslng-ennsfrnnpqPTR 237 fruit fly
Q9VD74 163 ----QLWHLPDSLSLFATLCEIFLEigslmiIHIGFVGYLSVAALYsEVNSFARIelrrqlrsler-pvggpvgrkqLRI 237 fruit fly
Q8IPU5 265 QELYKgqqkwlalelwrllHvhHQLLKLHRSICSLCAVQAVCFLGFVPLECTIHLFFTYFMKYskFILRKYGR-----SF 339 fruit fly
Q9VYZ2 206 DTYSD--------------L--MKQLRRRERLLRIGRRVHRMFAWLVAIALIYLVFFNTATIYlgYTMFIQKHdalglRG 269 fruit fly
Q9VEU0 198 PTNLA-----------------RLLQKEYSWL-RLIQRFVKLFQLGIFLLVLGSFVNIMVNIYafMSYYVSL------HG 253 fruit fly
O18280 265 QSLQQ--------------I--HDVQIHYQEISNAKLYIEQNFSFSLFYTYGCCIPLTCLLGY--IAFRNGI------QA 320 Caenorhabditis elegans
Q17990 263 SSLQK--------------I--HDCQISYQRIFNGKAVIEEYYSFVLFYSYGVCIPIFCFLMF--VGMSAQS-------I 317 Caenorhabditis elegans
Q9VB26 231 LCVAL-----------------KRNQLLLGRIWRLEGDVGSYFTPTMLLLFLYNGLTILHMVN--WAYINKFLy---dSC 288 fruit fly
Q8IMN6 232 ELCVT--------------L--KQNQLLIGRIWRLVDEIGAYFRWSMTLLFLYNGLTILHVVN--WAIIRSIDp---nDC 290 fruit fly
Q8IN22 220 QQRIR--------------V--QKSMALFKEISSVVTSLQDIFNVHLFLSALLTLLQVLVVWY--KMIIDLG-------F 274 fruit fly
Q8IN23 238 QAISN--------------L--DKCLYLYDEIHQVSRSFQQLFDLPLFLSLAQSLLAMSMVSY--HAILRRQ-------- 291 fruit fly
Q9VD74 238 VEYRV-----------------DECISVYDEIERVGRTFHRLLELPVLIILLGKIFATTILSYevIIRPELY-------A 293 fruit fly
Q8IPU5 340 PLNYFAIAFLVGLFTNLLLViLPTYYSERRFNctreIIKGGGLAF-----PSRITVKQLRHT--MHFYGLYLKnVEHVfA 412 fruit fly
Q9VYZ2 270 RGLKMLLTVVSFLVILWDVV-LLQVICEKLLA----EENKICDCP-----EDVASSRTTYRQweMSALRRAIT-RSSP-E 337 fruit fly
Q9VEU0 254 VPLTISNNCLVLAIQLYAVI-LAAHLCQVRSA----KLRKKCLQL-----EYVPEGLTQEQAmaSTPFPVLTP-TGNV-K 321 fruit fly
O18280 321 DMAETFSVAIWLTNTMLALM-LFSIPAFMIAE----EGDKLLTASfkmyhETLCEERDLLVLsqMSFLSFQMH-ATKL-T 393 Caenorhabditis elegans
Q17990 318 CWSEVVSIVIWIVNAILVLL-LFSLPAFMINE----DGDRLVASSfrmyhETFHEERDLTVLsqMTFFTFQIH-STKL-T 390 Caenorhabditis elegans
Q9VB26 289 CQYERFLVCSTLLVNLLLPC-LLSQRCINAYN----CFPRILHKIrc--tSADPNFAMLTRG--LREYSLQME-HLKL-R 357 fruit fly
Q8IMN6 291 CQLNRLGSITFLSFNLLLTC-FFSECCVKTYN----SISYILHQIgc--lPTAEEFQMLKMG--LKEYILQMQ-HLKL-L 359 fruit fly
Q8IN22 275 SDFRIWSFSLKNLIQTLLPVlAIQEAANQFKQ----TRERALDIF------LVGKSKHWMKS--VEIFVTHLN-LSEF-R 340 fruit fly
Q8IN23 292 YSFNLWGLVIKLLIDVVLLT-MSVHSAVNGSR----LIRRLSFEN-----FYVTDSQSYHQK--LELFLGRLQ-HQEL-R 357 fruit fly
Q9VD74 294 RKIGMWGLVVKSFADVILLT-LAVHEAVSSSR----MMRRLSLEN-----FPITDHKAWHMK--WEMFLSRLN-FFEF-R 359 fruit fly
Q8IPU5 413 VSACGLFKLNNAILFCIVGAILEYLMILIQFDKVL 447 fruit fly
Q9VYZ2 338 NNVLGMFRMDMRCAFALISCSLSYGIIIIQIGYIP 372 fruit fly
Q9VEU0 322 FRILGVFILDNSFWLFLVSYAMNFIVVILQTSFEH 356 fruit fly
O18280 394 LTAGNFFMMNRKIMISLFSAIFTYFLILVQFDAEK 428 Caenorhabditis elegans
Q17990 391 LSACNYFYMDRSILLSLFSAILTYFLILWEFDIKN 425 Caenorhabditis elegans
Q9VB26 358 FTCGGLFDINLKYFGGLLVTIFGYIIILIQFKVQA 392 fruit fly
Q8IMN6 360 FTCGGLFDINIKLFGGMLVTLCGYVIIIVQFKIQD 394 fruit fly
Q8IN22 341 VNLLGLFNVSNELFLIIVSAMFCYLVFVTQCVIVY 375 fruit fly
Q8IN23 358 VFPLGLFEVSNELTLFFLSAMVTYLVFLVQYGMQS 392 fruit fly
Q9VD74 360 VRPLGLFEVSNEVILLFLSSMITYFTYVVQYGIQT 394 fruit fly
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