Conserved Protein Domain Family
RWD-RWDD4
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cd23817: RWD-RWDD4 
RWD domain of RWD domain-containing protein 4 (RWDD4) and related proteins
RWDD4, also called protein FAM28A, is a target of the tumor suppressor MicroRNA (MiR)-506 in bladder cancer cells. Downregulation of RWDD4 suppresses bladder cancer cell proliferation, migration and invasion. RWDD4 has also been identified as a modifier of metastasis in human prostate cancer.
Links
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Statistics
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PSSM-Id: 467653
Aligned: 63 rows
Threshold Bit Score: 138.03
Created: 14-Aug-2017
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6NW29     8 EMELEALRSIYEGDESFRElsPVSFQYRIGENgd-pKAFLIEISWTETYPqtPPILSMNAFFNNtISSAVKQSILAKLQE 86  human
Q5DEU0     8 EEEAQVLKSIFSEDELTISg-DYNLEYKVGEHgt-iSSFVIQIQWPTGYPnvMPYISMDCFYNQhVPQDVKEKIVAELVS 85  Schistosoma japonicum
EDV29309  11 TEEAEVLCSIYESDENFKKisDQRFSFMFGDEgs-pKSFLVHIIWTENYPdaLPEFNLDAFYNNhLNSTQKKSIVDRLLL 89  Trichoplax adhaerens
KER22634   6 QEEAEVLASIYDPNELSVSd-DYTVEYKLGEHgt-pKSMILTIQWPDGYPtvLPTISLDSFYNGhLSTAVKLLVVKELNA 83  Opisthorchis viverrini
ESO02421   3 KEEYEVIKSIYEGDTKFTEvnPTTFSYKFDSEss-qKSFLVEFHWLENYPevPPDINLEFFCNKfLCKKTKNKIKEFVHD 81  Helobdella robusta
CDS42991   8 AEEKAVLKSIYTPDELSISd-DYKIQFRLGTPgt-lGSFVVNITWPKGYPfiPPVVDLDEFCNHhVPQSMRDSIIKELNE 85  Echinococcus multil...
CBY22912   8 EEELEALDAIFEDDECYEKisETEFSYKITPEgesgKNVKIDFKWGENYPeeAPEFGLESFYNThLTDATKECILEFLAN 87  Oikopleura dioica
CDS26710   5 AEEKIVLESIYTSEEISITd-DYKIQFRLGTPge-lESFVVNITWPLDYPsiPPIIDFNEFCNRnMPSALQQSLISELNE 82  Hymenolepis microstoma
TKR65145   8 EMELEVLNSIYEGDDRFRQsdPTKFQYKFGDEgh-yQSFIMEVIWTENYPesVPEVNLDVFYNSqITREVRDVIKDKVLA 86  Steinernema carpoca...
THD20348   6 AEEREVLQSIYEENELKFTd-DYTLEYRLGELdt-lRSLVLKISWPEGYPdiPPIISLDSFYNGhISSTLKDTILQDLNL 83  liver fluke

Q6NW29    87 AVEAnLGTAMTYTLFEYAKDNKEQF 111 human
Q5DEU0    86 VAEDqLGSALTYILVEYIKENHERF 110 Schistosoma japonicum
EDV29309  90 ESQElIGSALTYTLFEWIKEHLDEL 114 Trichoplax adhaerens
KER22634  84 LAQEqLGTAMTFSLIDYARENAERY 108 Opisthorchis viverrini
ESO02421  82 QAEPmLNSAMLYTIIEAIKEKVDTL 106 Helobdella robusta
CDS42991  86 LALEnSGEPLTFTLIEHLRDNIEEY 110 Echinococcus multilocularis
CBY22912  88 QAEEnLGDPMIYTLIEGVKDNIDDL 112 Oikopleura dioica
CDS26710  83 IASQnVGESHTFILIEHLRDNFEKY 107 Hymenolepis microstoma
TKR65145  87 EAKNnLGMASTFSLIEFVKENFDDL 111 Steinernema carpocapsae
THD20348  84 LAAEqLGTALTFSLIDQLKENSEKY 108 liver fluke
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