Conserved Protein Domain Family
TIM21

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pfam08294: TIM21 
TIM21
TIM21 interacts with the outer mitochondrial TOM complex and promotes the insertion of proteins into the inner mitochondrial membrane.
Statistics
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PSSM-Id: 311963
Aligned: 13 rows
Threshold Bit Score: 176.713
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P53220    67 QVKSASTFTFSGILVIGAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLqcddgitgKERLKAYGELIT 146 Saccharomyces cerev...
Q6FMZ2    43 KLKALTSFTASSLLVVGGVGVSGVVLYLILSELFSPSGDTMLFNRAVTLVEDNEEVRKLLqcndssfkKERLKAYGELVT 122 [Candida] glabrata ...
Q6BVK1   100 RIGRAFTFSLSSVIVLGATCISVLVVYLILSELFLPSGDTRTFNKAVRMLESNELAHEALgf----kkGQRVKAHGEQHA 175 Debaryomyces hansen...
Q6CAQ9    99 KIGVFFQLSWYLGIILAALGLFGLVWYYLIMELVMPSGDVRIFNRAFKEIEKNEDVMRVL--------GGQLSSMGEGGG 170 Yarrowia lipolytica...
O94618    62 KAYRTSANIGNFSIVIFGGGVFGLIIYALVTSIW--KGEAHYGDEAFELLKANEECRYVF--------GDHMKALGEATH 131 Schizosaccharomyces...
Q7S8S5    82 KAGRAVQQTFNFGLVILGVVLTGGIAYLLFTDVFSPESKTAYFNRAVDRIRADPRCVALLsp----gdPKKIAAHGEETH 157 Neurospora crassa O...
CAP20646  79 KVAEKASNTFMYTAVVAGVGLIGAFIYVLAGEFFAQDSPQTIFNKALALVREDGRCQDIF--------GASIAGFGEETS 150
Q28HE3    87 KVKEAGRDFTYFIVVLIGIGVTGGLFYVVFEELFSSSSPSKIYGEALEKCRSHPEVIGAF--------GEPIKGYGETTR 158 tropical clawed frog
Q5U2X7    99 KVKEAGRDVTYLIVVLFGVSITGSLLYTIFKELFSSSSPNIIYGKALGKCRTHPEVISVF--------GEPVKGYGEMSR 170 Norway rat
Q9VMR0    68 KIKENTKTASYTAIIIAGLGVTCVMFFAIFRELFSSESPNNIYADALRRVVEDPRVQDAI--------GAPIKGFGETSR 139 fruit fly
Q7PPN0    66 RVKENTKTASYMGVILLGVGVTGMLFYVIFWELFSSDSPNNIYSEALERVKEEPRVKDAL--------GAPIKGYGEETR 137 Anopheles gambiae s...
Q75CX4    63 KVRAAATFSASGMLVLGAAGVAGIVLYLILSELFSPSGDTQIFNRAVSTVEGDAVARSLLqcedgvhrSERLKAYGDSVG 142 Eremothecium gossyp...
Q6CW96    63 RIRAFTTFTFSGILVIGATGLAGVVIYLIGAELFSPSGDTQIFNRAVSKVENDEVARRLLkcndtetsTERLKAYGEILT 142 Kluyveromyces lacti...
P53220   147 NDKWTRNRPIVSTKKLDKEGRTHHYMRFHVES--KKKIALVHLEAKESKQN--YQPDFINMY--VDVPGEKRYYLIKPK 219 Saccharomyces cerevi...
Q6FMZ2   123 NDRWTRNRPIVSTQKIDKYGKCHHFMRFHLES--KKKLGLVHVEAVDSEQN--YKPNFVSMY--IDIPGEKRFYIIRPK 195 [Candida] glabrata C...
Q6BVK1   176 -DKWARNRPAQSVRTRGADGKDYLFMKFQVESp-SGKYGTVTLEQVDRTF---WSSEFLYIA--LDMPGNKRIYIKEPK 247 Debaryomyces hanseni...
Q6CAQ9   171 -GRWGRNQPPVSKRGIDKYGREHIWMNFYVSG--DINEGRAKLELVQNTDSklSSERFVYRYfvVDIPGHKRIYIAGNA 246 Yarrowia lipolytica ...
O94618   132 PLR--RTHGILTSRVWDHHGVEHLVLQFHLIG--NERKGHVFGRLVNVQ----GDYKWEYLF--VDVANYGKIIIFDHT 200 Schizosaccharomyces ...
Q7S8S5   158 -NKWRRARPIAATVEKDNRGVEHLKMHFHVEG--PRGSGVVGLHLTKQPGH--WEHEYQTFY--VDVRGHQRIYLENKE 229 Neurospora crassa OR74A
CAP20646 151 RGR----RRHVAHHKYEKDGMQRIRVLFHVKG--DRDEGIAQAEMEQRD----GDWEWRFLYveNKRRPKTTHVLIDNR 219
Q28HE3   159 RGR----RQHVSHMEYVKDGIKCMRLKFYIEGlePRKQGTVHTEVKENPES--GKYEFQYIFveIDTYPRRTIVIEDNR 231 tropical clawed frog
Q5U2X7   171 RGR----RQHVSFTEYANNGLKRIRVKFYIEGsePGKQGTVHAEVEENPRS--GQFDFRYIFv--DVAPKRSIVVEDNR 241 Norway rat
Q9VMR0   140 RGR----RQHVAHSSYERNGKPHMRMQFYVQG--LRNKATVQLESRRSDS---GKLEYRYLFvqLDHYPRTTIILEDNR 209 fruit fly
Q7PPN0   138 RGR----RTRVAHTQYVKDGVEHIRMQFHVQG--FRNRGTVHLEKRKTDA---GGYEYRYLFvqLDYNPHSPIILEDNR 207 Anopheles gambiae st...
Q75CX4   143 DDRWTRNRPISSTRRLDASGREHYYMRFHVET--GRRRGVVSLEAQQSDDS--YQPEFVRMY--LDVPGEKRHYLIRPE 215 Eremothecium gossypi...
Q6CW96   143 DDRWTRNRPISSTRRIDKEGKEHYLMRFHVES--KQKMGIVHVEAKESDVN--YQPDFVSMY--LDIPGEKRHYLIKPK 215 Kluyveromyces lactis...
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