Conserved Protein Domain Family
Pho86

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pfam11124: Pho86 
Inorganic phosphate transporter chaperone Pho86
Pho86p is an ER chaperone required for chaperoning multi-pass membrane proteins through the ER membrane compartment. It is essential for growth when phosphate levels are limiting, being involved in the regulation of Pho84p, a high-affinity phosphate transporter which is localized to the endoplasmic reticulum (ER) in low phosphate medium. When the level of phosphate increases Pho84p is transported to the vacuole. Pho86p is required for packaging of Pho84p in to COPII vesicles. This entry also includes the Uncharacterized protein C12B10.02c from S. pombe, which is thought to be an orthologue of S. cerevisiae Pho86.
Statistics
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PSSM-Id: 463226
Aligned: 29 rows
Threshold Bit Score: 166.327
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK43680       3 EQKDIDLNKPLDESAPATLSKSTLTPNLTRATTTLHGDRFKQAQAQLSRFVLLHPIAVSVYTIFFPSIIGRSLWEYIEIS 82 
XP_001385214   3 IQKVVDLNKPLDADAKATLEKSSLKPELAQAALALHGDRYRQLQSRLNRFLFWHPVFIIVFSIAIPTVLTYKLWDYISIS 82 
CCE40459       3 TQKDIDLNTPLDARAPSTLSKSALTPELTKAAVTLHGDRYKQSQANLTRFIIWHPYSLALYSLIFPSILVYALWDYISIS 82 
EGW33141       3 IQKEVDLNEPLDAHEAPTLSKTPLKPEFAKAALILHGDTYKQLQAKLNRFIFWHPIAIIAYFLLIPAALLYNLWDFVEVS 82 
EGV60253       3 IQTKIDLNKPVKSAPDPKLEVVALRPEFSEAALLLYGDYFRQCQTTLTKSILWHKQVVSIGLGVVSAYLYYILADYIEVS 82 
Q6BUK3         3 IQKDVNLNEPLNDKIPPTLGKTSLTPELSQAALILQGDYYSQLQGKCNRYVFWHPISTTFLVISTSIFTYYRLYDYISVS 82  Debaryomyces ha...
XP_004194708   3 IQKEVNLNVPLDVNKKATLSRTELTPDLAEASLVLHGDYYRQLQGKCNKYLFWHPLSLFILISGGLSFFLFRVREWIEVA 82 
EDK39636      17 AQKFVDLNEPLNPEAKPTLAKSSLTPEYAEASLILHGDYYRQLQGSCNRYIFWHPISMSIWVVGLVAAAAYFLRDYYAIS 96 
EEQ38394       3 KQVELNLSTPLKAEADPTIKPIPLEPALATAALTLHGDFYRQLQSKANHHIFWHPITQFVLTSTLCGFAYYTYSELIEIS 82 
Q10436         5 QRKRIDIRRP-------TLAELSSIRSIAMNALNGQSRNLSQK-------IFWHPLYLAVFGLVFMG------------- 57  Schizosaccharom...
EDK43680      83 DTALELF-WLLVRNkrdfVFALISAIPIIAAVFATFGTLAYFLGDELGTIANQF------VQKKYCDLIFGFNVREFAsi 155
XP_001385214  83 DSPVELLsFLIKSNd--fRFQILASLPLLAAVMGFVGITCFWVSEELRYISDKM------IQEGFAGEIFGFNIKTFSel 154
CCE40459      83 DNLVELY-FIASRNkrdfIFHIIKSGPTIAGIFGIFGFIAYILGDEVGAITDRY------VAQKYCDYTFGFDVKEFA-- 153
EGW33141      83 DSAWEFF-LLGKKNpkdfIYGIIAAFPMVAGIFATFGLITYIMGDDIGNITSAF------VAQKYCDKVFGFDIKKFAql 155
EGV60253      83 ESVGEFFsIAIHSAd--lKVNILFTSAVILGFIAFVGLISVMISDEFRIISENL------VKKSYVEDVFGFDLVKYSkl 154
Q6BUK3        83 ESFGEFFsFFIKSRd--fQFQVMGIFPWLVCVFGIVGIVTHFVSDVYKDISVKL------PQLKYIEKIFGFNLKEYArl 154 Debaryomyces ha...
XP_004194708  83 DSIGEFFkFFIKSRd--fQVEIFKTFPLAISIFGIIAVIAFMLSDVFRVISDDL------PKPEYSHALYGFDITKFAns 154
EDK39636      97 NGLLDFFaQFVARSd--mKFELIYLLPCTVLIFAFIGLSAHLLSDDLRDIADKL------DQPDRIEELYGFDLRKFAke 168
EEQ38394      83 DSIPEFL-FLAWNN----KYLVSSFFPVIIFLIGTIGIISFLVTDEFRVVSDSL------TDDATMSKIFRFPLRIYAny 151
Q10436        58 --------IYRLTNmvegNTKLRTFVLLILVSAVFLTLIEFPCRNVYAKISTEDnqpdgcLAEENLKHFYMARID----- 124 Schizosaccharom...
EDK43680     156 EDDfegnnnsnsnsnsnddndgvevktkeknnqkrklNKSQMKanlekGKNSEVVSYRGSPIAVASVVPDYEQSKPDYFI 235
XP_001385214 155 PSEptttqd---------------------------------vklyenGVNTQIILYRDSPIAICTVTPDLVNSTVENFI 201
CCE40459     154 --------------------------------------QDPKTpllknGKNSELIIYKDQPIAIGTLKPDWEQSTPDNFI 195
EGW33141     156 TGHetdvds---------------------------------ikllkkGLNTQIIMYRESPIAICTVVVDEEQSTPESFI 202
EGV60253     155 EGDskvlke---------------------------------kkilanGSNSQVVLFQEQPIAIITLKPIYDKSNDSHLV 201
Q6BUK3       155 SQStllkq--------------------------krklTPKEVvflknGANTHIVMYRDSPIAIITLIPLLDESSETEFV 208 Debaryomyces ha...
XP_004194708 155 ge--------------------------------mklTPKEKAaf--hGDYTQIIIYRDSPIAVITLRPLLDVSTDSNFV 200
EDK39636     169 DPNsr--------------------------------lSPKQKallqnGENTHLIVYRNSPIAVITLKPLLDNSTEANYF 216
EEQ38394     152 DENdksqnsl--------------------------------afiesaSQSTELIEYRESPIAIVTVIPLPDKSTSEVFY 199
Q10436       125 ---------------------------------------------------------KERVIGIIGILPANAPGAYQNTP 147 Schizosaccharom...
EDK43680     236 IKITGVHVRKVFQKVDFDQMLIEWAVLRSRQLYQDflkNGhhntsrvKDGSILITIDAYSFDKHFEKLLAKNGFKAIDVN 315
XP_001385214 202 VKISGLHIRKVFAKVDFDDLLIDWSIFRAREIYQDyvkSK----------NLKIVVDSYSFDKKFESTLLAKNFVIVDES 271
CCE40459     196 VNITGIHVRKVFKKVDFDQLLIEWAVLRARELYQEyllQKks---ktKNGTIFVVTDAYSFDKEQEGTLIRCGFKLLSSS 272
EGW33141     203 VEITGLHVRKVFENVDFHELLIEWAVLRTRELYEEyakQKkv---ktQEGTILITTDAYSFDKRLQTCLYNTNFGVMSKD 279
EGV60253     202 IKVSGLSVRRVFKPLNFEQILIEWALSRSNDLLTEylkAKkvk--ktSGCKVSLLVDCYTFDTEFAKFLESNRFNKIDST 279
Q6BUK3       209 IKITGLHVRKAFVKVDFDVLLLEWSYDRARDILKEygpNKd--------AKITLLADAFSFDNLLIKTLENQSFQKISSS 280 Debaryomyces ha...
XP_004194708 201 VRITGLHVRKVFAKADFETLMLEWSFTKARQIFQQhvkKSk-----vAGCKIQLLIDAFSFDRFYINALTKNSFGKVSSS 275
EDK39636     217 VRITGLHVRKVFVKADFHTLLIDWALLRSRQLFHEyskKKsd----vDSCKINILVDAYSFDKTYIKFLQSRSFGRVSSS 292
EEQ38394     200 ARITGLHVRKVYAKAGLQNELMEIAKLKAKSLCSRyvaDNki---ktKSMRIVLLAEGYTTDSIMTKIFKENNFKALEST 276
Q10436       148 TIVHWTVIPKFYQYA---FDLLDSALREAKEMGADvvsAR-----------------VYSTDPML-KAFERKDFTPVVDE 206 Schizosaccharom...
EDK43680     316 YTVNALDkdkkvg------------riyelL-YKLFGISTDTFALIL 349
XP_001385214 272 LELNPYkevst--------------kiqklI-HSFFGVSRRTLELDI 303
CCE40459     273 LELNPFspslk--------------syekfL-NRLLGISRDTFGLLL 304
EGW33141     280 VELNRFsdtln--------------kpkeiL-HKLLGVSRDTFGLAL 311
EGV60253     280 YNYNPIgeita--------------plkglL-NKTFRSGRDTYGVHI 311
Q6BUK3       281 FTLNSFEddsesktgi------lsyitstgA-YKTFGITKDTYRLTL 320 Debaryomyces hansenii
XP_004194708 276 YVLNPMVaketkksdkpvssqgilakissmLtHKVFNISRDTYGVTI 322
EDK39636     293 TLLDkskkgs---------------nliqsL-NKLLGITRDTFGVTI 323
EEQ38394     277 TNVNPFSdkqsadti-------lklipvsfL-MKIFGIYRVTYELEL 315
Q10436       207 AFD---------------------------Y-LSFFGLRRLVLQKNL 225 Schizosaccharomyces pombe 972h-
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