Conserved Protein Domain Family
COMPASS-Shg1
?
pfam05205: COMPASS-Shg1 
COMPASS (Complex proteins associated with Set1p) component shg1
The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.
Links
?
Statistics
?
PSSM-Id: 461586
Aligned: 83 rows
Threshold Bit Score: 52.197
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EDK43794      24 HLTTIYKKNGNFDKQRKELLENFkESETCKNLLLKLQIMIESKVKHDP-LILIKnKGKMAALIQGEIVNQrsgsHSLSnn 102
XP_015793131   7 KIVNDLKARGVFDEFRKECLSAVdTRPAFENLRQKIDGKVKNYLESLTwDASLN-RNQLREKLRRSLTES----DNVI-- 79 
EEC16872      20 SIVSHLKSRGLFDQLRRDCLGDVdTKPAYLNLKQRIEGYITKFLAMQTwTPDMN-KNHVRDIMRREINES----GMLS-- 92 
XP_018671965  10 RIVERLKTNGIFDEMRRDCLADIdTRPAFQNLKLRIENYVTSLLSAEVwTPTLN-KNQLRSKVRMSVMQS----GMLN-- 82 
Q68FB1        34 lIVEQLKSRGQFDGFRRDCLADVdTKPAYQNLRQKVDNFVSTHLDKQEwNADMN-KNQLRNGLRQSVIQS----GMLE-- 106 tropical clawed...
Q8IYS8        41 iIVGQLKSRGLFDSFRRDCKADVdTKPAYQNLSQKADNFVSTHLDKQEwNPPAN-DNQLHDGLRQSVVQS----GRSE-- 113 human
2_pfamImport   1 -IVNHLKSQGLFDQFRRDCLADVdTKDAFEMNLYCFENFLGNQKETHKwELKKN-KNKYCS-IKQQVARS----GMLE-- 71 
Q4RRX6        25 mIVEHLKNRGLFDEFRRDCLADVdTKPAYQNLRQKVDNFVTSHLSTQDwNPSIN-KNQMRNGLRQSVVQS----GMLE-- 97  spotted green p...
Q08CT1        24 lIVEHLKNKGHFDEFRRDCLADVdTKPGYQNLQQRVGTYVSTHLSTQEwNPTIN-KNQVRNALRQSVIQS----GMLE-- 96  zebrafish
XP_002114532  16 AFV---KSEGVFDQFRRDCNGDItQMDKYRQLEHFVQEYVNDWLLNERwTESSN-KNKHRNDLRQQVDRS----NKVK-- 85 

EDK43794     103 nttdkgtgvslsekesytqdsngpsNTILGIVDRDIqekiiesEEFQFAIKEE 155
XP_015793131  80 -------------------------ATIQHLVDQVIa------QKATTYMLSR 101
EEC16872      93 -------------------------AGMDHLVDQIVn------PKIYHVFTPE 114
XP_018671965  83 -------------------------TGVEYILHQVVd------SKMYSEFLPK 104
Q68FB1       107 -------------------------AGVDRIISQVVd------PKLNHIFRPQ 128 tropical clawed frog
Q8IYS8       114 -------------------------AGVDRISSQVVd------PKLNHIFRPQ 135 human
2_pfamImport  72 -------------------------SGVDRIISQVVd------PKINHTFRPQ 93 
Q4RRX6        98 -------------------------SGVDRIITQVVd------PKMNHTFRPQ 119 spotted green pufferfish
Q08CT1        97 -------------------------SGVDRIISQVVe------PKLQHIFRPI 118 zebrafish
XP_002114532  86 -------------------------ATLDSIISLNLr-------SRIENFRSR 106
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap