Conserved Protein Domain Family
MFS_SLC15A3_4
?
cd17348: MFS_SLC15A3_4 
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters
Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Links
?
Statistics
?
PSSM-Id: 340906
Aligned: 6 rows
Threshold Bit Score: 637.217
Created: 4-Feb-2016
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter
  • Comment:NRT1/PTR family proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA).
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ##  ##  #                                 #                        
Q8N697     34 RAACGAVLLTELLERAAFYGITSNLVLFLNGApfcWEGAQASEALLLFMGLTYLGSPFGGWLADARlGRARAILLSLALY 113 human
Q68F72     31 GLACAAVLLSELLERVAFYGITSNLVLFLNGQifgWEGTQASQALLLFMGITYLVSPFAGWLADALlGRFYVILGSMVLY 110 African clawed frog
KKF28463   35 RLACAAILLAESLERIAFYGITSNLVLFLNGSpfyWEGTQASQAPLMFMGVTYLISPFGGWLADAYlGKFWTIAFSLILY 114 large yellow croaker
EMP24421   32 KAACAAVLLVEILERAAFFGIVSNLVLYLNSSnfnWGGSQASRASLLFLGASYLLSPVGGWLADVYlGRYWTITLSFLLY 111 green sea turtle
Q8IY34     32 RAAGAAVLLVEMLERAAFFGVTANLVLYLNSTnfnWTGEQATRAALVFLGASYLLAPVGGWLADVYlGRYRAVALSLLLY 111 human
XP_415099  30 RLACAAVLLAELLERVAFYGITSNLVLFLNGPpydWEGAQASQALLLFMGITYLVSPFGGWLADALlGKFGTILLSMALY 109 chicken

Feature 1                                                                       ## ###  #     
Q8N697    114 LLGMLAFPLLAApatraalcgsarlln------------ctapgpdaaarccsPATFAGLVLVGLGVATVKANITPFGAD 181 human
Q68F72    111 LLGMLLFPMVSYsgtrtafcgdiqwaqiencs--rsnassddtcpepsrrycaPALFLGLIIVGLGVGSVKANITPFGAD 188 African clawed frog
KKF28463  115 IMGMLFFPFISNedtrielcgeemafpvqpie-ctngtppsnvtcpirapycgAVVYSGLFLIAVGVGTVKSNITPFGAD 193 large yellow croaker
EMP24421  112 LVSACLLPATASldgrlflcgdmpayslqnt----cqnqsgecqqsapshycaPLMYTGLLLLALGISSVKANLTPFGAD 187 green sea turtle
Q8IY34    112 LAASGLLPATAFpdgrssfcgempasplgp------acpsagcprsspspycaPVLYAGLLLLGLAASSVRSNLTSFGAD 185 human
XP_415099 110 LLGMLAFPVIAAphtrqglcgdiplypvencsspatnatlapcsqvgttrycaAATFVGLVLVGLGVGSVKANITPFGAD 189 chicken

Feature 1                      #  ##  #                                                       
Q8N697    182 QvkdrgpeatrrFFNWFYWSINLGAILSLGGIAYIqqnVSFVTGYAIPTVCVGLAFVVFLCGQSVFItkppdgsaftdmf 261 human
Q68F72    189 QvkdrgpeatrrFFNWFYWSINLGAIISLGGVAYVqqnVEFLIGYIIPAVCIGVSFLVFLCGKTVFVtkpadgsaftdmv 268 African clawed frog
KKF28463  194 QvkdrgpeatrrFFNWFYWCINLGAIMSLGFVAYIqqnYSFELGYIIPTVCLGVSFLVFILGRTVFInkpadgsaftdmf 273 large yellow croaker
EMP24421  188 QvtdrgrnatrrFFNWFYWSINIGAVISLLVVAFIqqnVNFLIGYTIPAACVALALLVFLLAAPTFItkppagsqvsaml 267 green sea turtle
Q8IY34    186 QvmdlgrdatrrFFNWFYWSINLGAVLSLLVVAFIqqnISFLLGYSIPVGCVGLAFFIFLFATPVFItkppmgsqvssml 265 human
XP_415099 190 QvkdrgpeatrrFFNWFYWSINLGAILSLGGIAYIqqnVSFVIGYSIPAICIGISFMVFLCGQSFFItkppdgsaftdmf 269 chicken

Feature 1                                                                       #  ##  ###  # 
Q8N697    262 kiltysccsqkrsgerqsngegigvfqqsskqslfdsckmshggpfteekveDVKALVKIVPVFLALIPYWTVYFQMQTT 341 human
Q68F72    269 kilayfccsrkhtrentr---niqnnqhrhkqsrldmakashggpfredkveDVKALVKIIPVFLALIPYWTVYFQMQTT 345 African clawed frog
KKF28463  274 rilgfaccsqkpket----------nlirnkptlldsakvtyggkfpeekvdEVKSLVKILPVFFALIPYWTVYFQMQTT 343 large yellow croaker
EMP24421  268 rlawrgscgsrarrirp-----sslqseaqgadplldgksqprapsseedlaNFQVMAKILPVLLTFIPYWMVYFQMQST 342 green sea turtle
Q8IY34    266 klalqnccpqlwqrh---------sardrqcarvladerspqpgaspqediaNFQVLVKILPVMVTLVPYWMVYFQMQST 336 human
XP_415099 270 kilaysccsrkrhmehstnsegqgvlqqprkqslfemaklsrggpfredkveDVKALVKIIPVFLALIPYWTVYFQMQTT 349 chicken

Feature 1                                                   #   #                             
Q8N697    342 YVLQSlhlripe-----------isnittTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILrrhgllpSSLKRIAVGMF 410 human
Q68F72    346 YVLQSlhlri--------------pqifnNNHTLPAAWLTMFDAVLILILIPLKDKLVDPFLkkrgllpSPLKRIAVGMF 411 African clawed frog
KKF28463  344 YILQSlhlkipgsp------pnntagfhqMTFRFPAAWLTMFDAVLILMLIPLKDKVVDPILkrrgllpSSLKRIAVGMF 417 large yellow croaker
EMP24421  343 YYLQGlhlfipnif------qhnrtgssaGSYAFPDAWLLLANVVVLLILVPLKDRVIDPFLvrrkllpSVLKRMALGMF 416 green sea turtle
Q8IY34    337 YVLQGlhlhipnifpanpanisvalraqgSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLlrckllpSALQKMALGMF 416 human
XP_415099 350 YVLQSlhlkipe-----------iandtnSVHTFPAAWLTMFDAVLILILIPLKDKLVDPVLkrngllpSSLKRIAVGMF 418 chicken

Feature 1                                                           ##   #   #               #
Q8N697    411 FVMCSAFAAGILESKrlnlvkektinqt-ignvvyhaadlsLWWQVPQYLLIGISEIFASIAGLEFAYSaaPKSMQSAIM 489 human
Q68F72    412 FVMCSVLAAGILESErleivkrdkiqqq-ignvtyyaanltVWWQLPQYILIGISEIFASIAGLEFAYSaaPKSMQSVIM 490 African clawed frog
KKF28463  418 FVMWSAVAAGILETKrleivksngtidqvlgnviyyaadlpIWWQVPQYVLIGISEIFASIAGLEFAYSaaPKSMQSAIM 497 large yellow croaker
EMP24421  417 FGLTSIIVAGTLETKrlqyvknnqtisqrigedmytaatlpIWWQIPQYLLIGISEIFASIPGLEFAYSeaPKSMQGAIM 496 green sea turtle
Q8IY34    417 FGFTSVIVAGVLEMErlhyihhnetvsqqigevlynaaplsIWWQIPQYLLIGISEIFASIPGLEFAYSeaPRSMQGAIM 496 human
XP_415099 419 FVMCSAFAAGILESNrlkivkvktinqt-ignvtyhaadmpIWWQIPQYVLIGFSEIFASIAGLEFAYSaaPKSMQSAIM 497 chicken

Feature 1       ##  ##  #                                                        
Q8N697    490 GLFFFFSGVGSFVGSGLLAlvsikaigwmsshtdfgningcyLNYYFFLLAAIQGATLLLFLIISVK 556 human
Q68F72    491 GLFFFFSGIGSFVGSGLLAlvsipqigwmsnhsdlgningctLNYYFFLLAAVQAATLLLFLIISVK 557 African clawed frog
KKF28463  498 GLFFFFSGIGSFVGSGLLAlvsikeigwmsshkdfgnindcsLHYYFFLLAGIQGVTLLVFLPISVK 564 large yellow croaker
EMP24421  497 GLFFFISGVGSLLGSGLLTllsmsehgwmdcpkdygninnchMDYYFFLLAGIQTVTCMLFFWISGR 563 green sea turtle
Q8IY34    497 GIFFCLSGVGSLLGSSLVAllslpggwlhc-pkdfgninncrMDLYFFLLAGIQAVTALLFVWIAGR 562 human
XP_415099 498 GLFFFFSGIGSFVGSGLLAlvsikeigwmsnhtdfgningcqLNYYFFLLAAIQGATLLLFLIVSVK 564 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap