Conserved Protein Domain Family
CobD_Cbib
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pfam03186: CobD_Cbib 
CobD/Cbib protein
This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein. This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate.
Links
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Statistics
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PSSM-Id: 460839
Aligned: 467 rows
Threshold Bit Score: 124.489
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011933664      1 MIaAAGFDWLIGDPHWSPHPVVWMGRAIHWLRQrlePwaGdrpRALRL-------SGgliTAALVLTSAGAGWLIERlwl 73  Synechococcu...
WP_014433656     19 LL-AIGIDWLWGDPGNRWHPVAWMGTAIAGLRR---Ca-P---QRgrga---alfYG---LCLAGGGAAASAWMVRLls- 83  Caldilinea a...
jgi:Haur_1057     9 LL-ALACDALLPELPNQLHPVVWMGKWIKRGEQ---FapSnead--------rlvWG---AIWLGAGMGLSAGLAARipk 73 
jgi:Caur_2573    15 LL-ALVLDFALGDPPNQLHPVSLMGHWLKWGER---LapAtpla--------rlaWG---GGWLYGGWWLVGRVASRlpr 79 
jgi:RoseRS_0564  15 LI-ALIADALLGDPPNAWHPVALMGRWMHLGER---FapQgata--------rllWG---GMWLTAGAAATGSVVALlpd 79 
Q53WA0            4 LL-ALLLDALFGEPPSRLHPVVWMGRYLAWAWR---Rvrg-------------fpSG---AFYWALGALLFALPAFLld- 62  Thermus ther...
WP_012204652     48 PV-ALLIDRLWGEPPVWIHPVVAMGRLLAAVGR---RlaP---REEHVrdwprfaLG---AVAWCLLALLFFTIYAFiq- 116 Delftia acid...
CAS:CtCNB1_1850  46 LV-ALLLDRLWGEPPVWLHPVVLMGKLLGWSGQ---AlaP---RAEVQrdylrfcLA---AIVWCALAALFFMVYGLaq- 114
WP_013457030      4 LL-AALLDAVFREPPARLHPVVGIGRLLAGLEcfwr---------------agagAG---ALAWLAGAAAVLALSSLaw- 63  Oceanithermu...
Q1AYA9            9 LL-ALLLDLALGEPPERAHPVVWTGRLVSLLER---KapSgpra--------allWG---AL-LAAAAALLPALAAAaa- 71  Rubrobacter ...

WP_011933664     74 qsSG---------LWqwaagvilIVALASALAARSLHDSVMAVVKALpakgdEEPTLARERLS-WIVGRETKQLSGNEIL 143 Synechococcu...
WP_014433656     84 daLSrmpmpvavlLE--------AVLLKMTFSLRGLLTAGGSVKAALe---qGELDAARRLLAwHLVSRDVSQLDASQVA 152 Caldilinea a...
jgi:Haur_1057    74 ----------hplAQ--------ALAAQSLLAYRALDRAVGEVQTALv---aDDLAEARRLLSwHLVSRDTAELSPSEVA 132
jgi:Caur_2573    80 ----------hllVQ--------GACVSLLLAYRGLDRAVAGVEQALr---tGNLAEARHLLGwHLVSRPTADLSAAEVA 138
jgi:RoseRS_0564  80 ----------hpvVR--------GLAASTLMAYRGLDRAVGEVQTALe---rGDLAEARRLLGwHLVSRPTADLRADEVA 138
Q53WA0           63 llLRplaw--gwvVL--------GLLLKPLFSLRMLLLEVFGVEKALe----EGLEAGRRRLS-RIVSRRTEDLSAEEVR 127 Thermus ther...
WP_012204652    117 wlLPpmpwwlgalVL--------GVLLKPLLSWRMLRDEVLAVEAALq----QSLPAGRERLT-WLVSRDTARLDAGQVR 183 Delftia acid...
CAS:CtCNB1_1850 115 fmLGfapwwlwglVM--------GVLLKPLLSWRMLKDEVLAVEAALq----QSLPAGRERLS-WLVSRDTTQLDAATVR 181
WP_013457030     64 wgVSaleapgralLA--------GLLLWPAFSLQMLTGEVAAVEAALs----RDLDEARARLA-RLVSRDTRGLDAAGVR 130 Oceanithermu...
Q1AYA9           72 lrLPlpr----lpAE--------AFLLKCCLSCRALEEAALGVARPLe---aGDLERAREALR-SLVSRDRSALDASLAA 135 Rubrobacter ...

WP_011933664    144 RAAAETASENAVDGVFAPLFWMlvgva--lwsaGwlqspgplALAwgFKASSTLDSMLGYR--------RGRLRWLGTAG 213 Synechococcu...
WP_014433656    153 AATIESLAENLSDGVLAPLLYYalmpraewglpA--------AYA--YRFLNTADAMLGYR--------DAEREWLGKAS 214 Caldilinea a...
jgi:Haur_1057   133 AAAIESLAENLSDSVIAPLFWYlaa-----glpG--------LAA--YRMSNTFDAMWGYR--------NQRFEYLGKVA 189
jgi:Caur_2573   139 GAAIESLAENLSDSIIAPLLAFlvg-----glpA--------LAI--YRLTNTADAMWGYR--------TERYEYLGKIA 195
jgi:RoseRS_0564 139 GAAIESLAENLSDSLVAPALALlvg-----glpA--------IAV--YRLSNTADAMWGYR--------NERYEYLGKTA 195
Q53WA0          128 EAALESLAENLSDSLLAPLLYYalf-----glgG--------AAL--YRYANTADAMWGYPehg----------arGAFA 182 Thermus ther...
WP_012204652    184 ESAIETLAENLSDSVLAPLFWFava-----glpG--------AAL--YRLANTADAMWGYPgwrgqgddRRHWQWAGKWT 248 Delftia acid...
CAS:CtCNB1_1850 182 ESAIETLAENLSDSVIAPLFWFava-----glpG--------AAV--YRFANTADAMWGYPgwrgqgkrRRHWQWAGKWA 246
WP_013457030    131 MAALETLAENLSDSLVAPLFYFvlf-----glpG--------AWL--YRYANTADAVWGYRtp-----rYRRWGW---LA 187 Oceanithermu...
Q1AYA9          136 SAAVESLAENLGDALVAPLLFYaag-----glpA--------AAL--HRGANTADAMVGYR--------G-RYERLGKAA 191 Rubrobacter ...

WP_011933664    214 ARLDDALTWLPCRLVMVTLPLIsrswwfwpSL----------VRAAERDGAADPSPNAGRSEAIYAHCAGVELGGWNRY- 282 Synechococcu...
WP_014433656    215 ARLDDLANLIPARVTALLIIAC--------ARaadgs-srhaWRIWRQDARQTASPNAGHPMAAMAGALGVALEKVDHYv 285 Caldilinea a...
jgi:Haur_1057   190 ARCDDALNLVPARLTAGLLWLV--------AHgqr----qrtWQVVWRDHGKTASPNAGWPMAAMAGALDTQLIKIGHYa 257
jgi:Caur_2573   196 ARCDDAFNLVPARLTALLLALA--------THlingr-gwhaWQTALRDARHTASPNAGWPMAAMAGALDTVLTKRDHYa 266
jgi:RoseRS_0564 196 ARLDDALNLLPARLTAALIAAA--------AQivcgr-gmiaWQIARRDAGRTASPNAGWPMAAMAGALDTTLTKRGHYt 266
Q53WA0          183 ARADDLLNLLPARLTGLLLCPP--------GL----------WGRLLQEARKTPSPNAGFPMAALALRLGVRLRKRGAYa 244 Thermus ther...
WP_012204652    249 ARADDLLNWIPARLTALLL-----------ALsglaagrrpgWGALRHDARITPSPNGGWPMGAMARLLGVRLGKPGVYv 317 Delftia acid...
CAS:CtCNB1_1850 247 ARADDVLNWIPARITAMWL-----------ALlag----glsWTGLRRDAAVTPSPNGGWPMGAMAQALGVQLSKPGVYr 311
WP_013457030    188 ARADDLLNWIPARLTGLLLAPR--------GL-----------AALRREAGRTPSPNAGWPMGALALALGVRLEKRGAYv 248 Oceanithermu...
Q1AYA9          192 ARLDDALNLLPARLAALLLAAA--------SGgra----reaWRAALAGHRATQSPNAGWPIAAAAGSLGLVLRKPGHYa 259 Rubrobacter ...

WP_011933664    283 -GntwIEKpLlgaggAQaDPRGVRTILSLS 311 Synechococcus sp. WH 7803
WP_014433656    286 lG---AGS-P-----NP-DSGDIGRALRLV 305 Caldilinea aerophila
jgi:Haur_1057   258 lG---DGL-T-----QP-DPALMQTARQLA 277
jgi:Caur_2573   267 lG---DGS-C-----IP-DAAMIGQARRIV 286
jgi:RoseRS_0564 267 lG---SGS-R-----LP-DAAMIGEARRIA 286
Q53WA0          245 lN---PLA-P-----SP-KASHTRKALWLV 264 Thermus thermophilus HB8
WP_012204652    318 lN---PAG-R-----VP-QAAELQQAVAHA 337 Delftia acidovorans
CAS:CtCNB1_1850 312 lN---PQG-R-----AP-QAADLKLSVKLA 331
WP_013457030    249 lH---PSG-R-----AP-EPADLRRALVRV 268 Oceanithermus profundus
Q1AYA9          260 lG---APG-R-----EP-AAGDIRRAVSLY 279 Rubrobacter xylanophilus DSM 9941
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