Conserved Protein Domain Family
Pep_M12B_propep

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pfam01562: Pep_M12B_propep 
Reprolysin family propeptide
This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.
Statistics
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PSSM-Id: 460254
Aligned: 210 rows
Threshold Bit Score: 71.9616
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005619041   39 DVTVPCSTDF-RgrflshvlsrpaaastgsgvvegppaaqspsghlRVARSLRRPEGaslqpgrvgrSSLYFNVTVFGEE 117 
XP_004364297   39 SLGNAVMASHhS----------------------------------RSRRSAADTAD----------ATIPLEFEAYGRT 74  
EGD74296       94 SDVSHVHVQR------------------------------------RRRRSTFEEELfgkae--ptsehHEVRFSAHGRV 135 
Q0IIY0        136 NLEIDPSIQ----------------------------------------RIRTEEREq--------iKTLNNKFASFIDK 167  tropical claw...
NP_001099890   53 HIVSPVQVDA-Sghflsygl-------------------hhpvtgsRKKRAAGGSG-----------DQVYYRISHEEKN 101 
XP_011477173   42 SVVHPVKTSA-Dgefisnev-------------------shhfnmgRHRRDLQGQPPq---------RQVYYQLSYKGRN 92  
CAG08585       51 SIVHPVKTTA-Dggfishsv-------------------shhfkggRFRRDLQACLE----------ERVYYRVTYKGRA 100 
XP_014324044   48 SIVHPVRISA-Dgefishsv-------------------shhfktgRSRRALRSLSPe---------GQVYYKLNYNGRA 98  
EEN57626       54 DVVHPVRVSP-Dgefishrv-------------------vhsehhhLHRRGAGDQGRpss----sqaDGLHYKVTVDGVD 109 
XP_011478010  242 iyvqlnvrvvlvgleiwthqnpistegeagevlsrftqwrekelvprrrhdsaqlilkksfggtagmafvstvcsrshgg 321  Japanese medaka
XP_005619041  118 LHLRLRPNRRLVVPGASVE-WQEDFRELFR--QPlr--reCVYTGD-VM---GMP---G-AAVAISNCD-G---LaGLIR 180 
XP_004364297   75 FRVTLRPNTDMVKPSARVTiYSDAGTRVEPvdVS------VAFKGS-IQ---GHS---S-SAVYATVVEsGdvvA-TMRD 139 
EGD74296      136 FDLRLVKNHRMFAHGIRAR-IIDENGKVTP--FRvd--aeNYLVGHdMS---DEA---N-SHANLYIRD-Gv--LaGFMH 200 
Q0IIY0        168 VRFLEQQN-----KVLETKwNLLQEQGVKS--VKcn--idPLFEAY-IS---ALR---RqLDSLLSEKV-R---LdSDLR 227  tropical claw...
NP_001099890  102 LFFNLTVNWEFLSNGYVVE-RRYGNLSHVK--MAassgqpCHLRGT-VL---QQGptiRmGTAALSACQ-G---LtGFFH 170 
XP_011477173   93 LKFNLTANEHLISNDYVLE-KRKDNTTEHR--FFqg--nsCHLIGT-VE---ASG---VrGTAAISTCK-G---LtGFFS 156 
CAG08585      101 LAFNLTVNPHLVSSDYVLE-RRNGGANRTE--QPssegnsCHLIGT-VE---TSE---ErGSAAVSTCG-G---LrGFFS 166 
XP_014324044   99 LMFNLTKNHHLLSTEYVLE-RRNGSASRAE--PVlsegnsCHLLGT-VE---APD---VkGTAAISTCK-G---LrGFFS 164 
EEN57626      110 LHLDLRLNPALLAPGYVLErHRGNVSRAAV--TRgpt-npCHYVGT-VPtsrDSS-------VAISTCS-G---LrGLIR 174 
XP_011478010  322 ginaFTNNRIPAFASIVAH-ELGHNLGMNH--DDgrt-csCPVDAC-IM---NSG---TtGSRNFSSCS-Ad-dFeKMIL 388  Japanese medaka
XP_005619041  181 TDSSDYFIEPLEwgQQEKEAGGRTHVVY 208 
XP_004364297  140 EDGEMYYIEPSH--RHLREAHEFDHVIY 165 
EGD74296      201 VHNNTFFVERSL--HHYPNDSSIDMIVY 226 
Q0IIY0        228 QMQDA--VEDYKk-KYEDEINKRTSVEN 252  tropical clawed frog
NP_001099890  171 LPHGDFFIEPVk-kHPLTEEGYQPHVIY 197 
XP_011477173  157 LPEGHFFIERVQksPDDAAGLPQPHIIY 184 
CAG08585      167 LPEGQYFIEPIQtsSQNATEAPEPHIIY 194 
XP_014324044  165 LPEGHFFIEPAQklPSDPAGTPEPHVVY 192 
EEN57626      175 TGKDDYFIEPVRg-HNVSAAEKHPHLIY 201 
XP_011478010  389 VTGGMCLMNVP------RPDE-----AY 405  Japanese medaka
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