Conserved Protein Domain Family
SIT

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pfam15330: SIT 
SHP2-interacting transmembrane adaptor protein, SIT
SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.
Statistics
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PSSM-Id: 464650
Aligned: 31 rows
Threshold Bit Score: 64.7147
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007482750 180 HLLPIIFGILLMF-VAVSILVWRMMLRQKKEAEKLAKE----------Q--TTeegicYAHLTLQQRtfrdthlDFPEEE 246
XP_004175261   8 WGALAFLSLALLVsLTLNIVHYIKKKQAKMHKDYEESNpsyd--gyhtEddPV-----YGNLNQ----------DILEEC 70 
Q3UU67        12 WGLLAFLGLALVIsLIFNISHYVEKQRRDEIYRY-SDDyiprvdeyyvEdaPI-----YGNLENIIP-------EPLDEN 78  house mouse
XP_013007180  12 WGLLVLLGLALIIlLIFNISHHVEKQRQDKMYRY-SDDyipradeydiEdtPI-----YGNLDNVIL-------DPIDED 78 
XP_005602073  12 WAILAFLGLALVVsLIFNISCYVEKQRQGITYRF-SDDyisredeyyiEdtPI-----YGNLDNVIP-------EPMDEN 78 
XP_024847707  16 WAILAFLGLALTIsLIFNIFHCVEKQRQEKICTY-SDDyfpredeydlEdsPI-----YGNVDNVAL-------EPVDEN 82 
XP_023396173  12 WGLIALLGLALVIsLIFNISHYVEKQRQEKLYRY-SDDyiprddeyyiEdtPI-----YGNLDNVVP-------EPTDEN 78 
XP_004036074  12 WGLLALLGLALVIsLIFNISHYVEKQRQDKMYSY-SSDhtrvd-eyyiEdtPI-----YGNLDDMIS-------EPMDEN 77 
XP_017202604  12 WGLLAFLGLALVIsLIFNISHYVEKKRQDYMYRYSDDYiprvdedyixDt-PI-----YGNLDNIIP-------EPIDEN 78  rabbit
XP_016153177   8 WGVLAFLSLALLVsLSLNISHCMKKKQA-KMHKD-YKEnnpsydgydtEdyPV-----YGNLNQ----------DILEEC 70  Collared flycat...
XP_007482750 247 ASPKASNRVNSSYNEVE--YVTMASLRGENISYDTLSLDMPDQ 287
XP_004175261  71 CYEQMKSQPQRPVNQLQ-------VESANQMCYASLDHSVKRK 106
Q3UU67        79 CYEQMKGRPQRSASDPQevAAPAQVPAEAQMCYASLDHSVKGK 121 house mouse
XP_013007180  79 CYEQMKARPERSVNNAQevASSTQVTAEAQMCYASLDHSFKGK 121
XP_005602073  79 CYEQMKARPERSVNQLRaaPTPAQATNEAQMFYSSLEHSLEGK 121
XP_024847707  83 CYEQMKARPDRSVNKLQd-aPPSQETA-VRVCYASLDHNNEGK 123
XP_023396173  79 CYEQMKARPERSVNKRQeaSIPAQAASDTQMCYASLNHSAKGK 121
XP_004036074  78 CYEQMKARPEKSVNKMQeaTPSAQATNETQMCYASLDHSVKGK 120
XP_017202604  79 CYEQMKARPERSINETQevPPSTQATTETQMFYASLDHSFKGK 121 rabbit
XP_016153177  71 CYEQMKSQPPRPVNQLQ-------VEPANQMCYASLDHSAKGK 106 Collared flycatcher
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