Conserved Protein Domain Family
SpoU-like
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cd18097: SpoU-like 
SAM-dependent rRNA or tRNA methylase related to SpoU
RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349970
Aligned: 28 rows
Threshold Bit Score: 195.091
Created: 8-Aug-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative SAM
Feature 1:putative SAM binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other SPOUT methylases
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   # 
AII52429   20 LTLVLDNVRSLHNVGAAFRTADAFAvEKIWLCGITGRPpqreitKTALGSTESVAWEYApttLEALQQLKaaGYQLIAVE 99  Hymenobacter sp. A...
CBW25821  117 IHLVLDNLRSSFNVGSLFRTAEAIGiKEVHLCGYTPTPensktaKSALGTDKWIKWSYWessLDCIDALKerGASIYAFE 196 Bacteriovorax mari...
AFU99214   23 LSILVDNFTAPANVGAVFRSADAFGaGKLYLCGDTICPpnsklrRLSRAAEKYVAWEHRddaLALVRELRaaGTCIISLE 102 Simiduia agarivora...
Q6MMA4    108 LVFVLDNIRSAFNVGSIFRTAECLGaEKIYLCGYTPLPtqwkveKTAMGTQEYLAWEEApklLECLEELKdeGYRIVALE 187 Bdellovibrio bacte...
AGW14028   34 LALVCDSLRHASSAGNVLRLADAFMlEKVWLCGDAALPgspkmrRSTKGVERWVPWELAedpLPVVQQYRerGYTIICLE 113 Desulfovibrio giga...
EDY50587   27 VALLLENVQSPFNVGSIVRTAAALGvGRLYLAGNTASPrnakaqKICMGTDRYLDVQTFetlPEAVERVRadGYRLVGLE 106 Streptomyces clavu...
EKX44504   13 LVVILDNLRSAFNVGSIFRTSECLGiESIILCGYTSTPedsqtsKAAMGMDKIMPWKWMktvEEAIAEMKarNYTVVALE 92  Guillardia theta C...
CDA30390   28 IYIVLDSLKVAHNIGTILRLSDALLiKKVYICGNTIVPpnykikCSSRGAEKWVDWEYVedaTQIVKKLKsnGVEITSVE 107 Clostridium sp. CA...
EDM25535   19 VIVVLDRLRSAHNVGNIFRLADAANvEAVYTCGYTASPphpkleKTAMGTDEFVNCEHFdhsLEAVGSLKknGYRVYAVD 98  Lentisphaera arane...
ACZ41412   29 LVFLLQDLEDPVNVGAAFRIADGCEaSEIILTGKTPTPpdstiaGVGRGAHRRIPWRYVehaDEALVELKgmGYMACAIE 108 Thermobaculum terr...

Feature 1     #                     ####  #             ## #     ## #  #        
AII52429  100 QttgSVPLPEfqveagqPYALIMGNEVfGVEDEVLAlcDAAVEIPQFGTKhSLNVSVAAGVVLWEF 165 Hymenobacter sp. APR13
CBW25821  197 TeknAKALEEvre--irECAIVLGNERyGLNESVLNrsDEILKIRLDGKKnSLNVGTCGAIAMYHM 260 Bacteriovorax marinus SJ
AFU99214  103 ItehSRPLNRftl-pdgPVCLILGAEDrGVAPALLAesHAVVHIPMGGSNsSLNVGSACAVALYQF 167 Simiduia agarivorans SA1 = DSM 2...
Q6MMA4    188 TaasASDLFEkfe--sePTAFVLGNERfGLDPEVLKiiDEVRIIPLRGRKnSLNVGVTAAVAGFEW 251 Bdellovibrio bacteriovorus
AGW14028  114 LaetSVSPYDarl--pmPACLVLGNERrGVDPRILAlaHVVLELPSQGMGnSMNVGSAAAISIFEI 177 Desulfovibrio gigas DSM 1382 = A...
EDY50587  107 LadeAVPLHEadl--sgATCIAVGNEDhGISPQALGmcDAVAFIPQLGRVgSLNVATALAVACYEV 170 Streptomyces clavuligerus ATCC 2...
EKX44504   93 TvvgCPDISSfsf-prtGCALVLGNERyGIDSSHVSlcDAVVKIPCRGIKnSLNVASAYGICAYEI 157 Guillardia theta CCMP2712
CDA30390  108 VasnSIDYRQyep--kfPLCLILGREYdGVSQELLDlsDNVIHLPLLGMSnSINVSTAASVVMYYA 171 Clostridium sp. CAG:492
EDM25535   99 TidsAIDVHEaqf--sgKCAFVFGNEAlGIQQETLEacDEYIRLNAHGRKnSINVSNCAAVVLFQA 162 Lentisphaera araneosa HTCC2155
ACZ41412  109 VaegAVPYYSlky--pdRVCLVVGHEYhGVTTRTLSvcDNAVYIPMYGKIkSLNVHVALAVVAFHV 172 Thermobaculum terrenum ATCC BAA-798

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