Conserved Protein Domain Family
DUF2045

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pfam09741: DUF2045 
Uncharacterized conserved protein (DUF2045)
This entry is the conserved 250 residues of proteins of approximately 450 amino acids. It contains several highly conserved motifs including a CVxLxxxD motif.The function is unknown.
Statistics
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PSSM-Id: 462872
Aligned: 21 rows
Threshold Bit Score: 213.736
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFJ47588      29 QQWCEAFSFLFL-AAPGSRHallEHQDDMLWFVtATNVLgPGTp---------PVTLRRntsseLAPELrlg-gsAFTSV 97 
KRH52131      43 RFWHDVFDLYFV-CGKESRG---RQDDDLVFFV-RKLGS-HGSgsnnktesvdPYFVRR-----WAPKLsdlvdeTSIDV 111
XP_004238070  42 RFWHGVMDVYFI-RGRESRG---RQEDDLVFFV-KKLHL-QKHgsnenesansPYFVRR-----WAPKLddligaSASDV 110
ANM58640      43 NFWHGVFDVYFV-RCMESRR---RQDDDLLFFV-RKLSC-KSYgltenedapaPYFVRR-----WAPKLdellgeSLAEV 111
XP_002320676  43 RFWHDVLDLYFI-RGKESRR---KQDDDLVFFV-RKRNT-QGYgfndsvesaaSYFVRR-----WAPKLdnlvseSSAEV 111
XP_003573754  66 KFWHEMLDLFFV-RGRVSKS---REEDDLVFFV-NSMKT-HGFed------ppPFFVRR-----WAPKLeklinvSASEI 128
XP_009387109   4 EFWHEVLDLYFI-RGRVSKG---REEDDLVFFV-RKMNL-HGYgysddvedgsPFFVRR-----WAPRLekvvgeDSACV 72 
XP_004994312  17 gRWADVLQQHFVe---------tEAGDDLIFFV-PRNLElSGSkdk----dqaQLKVYRrggtrPLPKR------GCSEI 76 
XP_009026491 119 TFWTFLFQTYFL-----NADdqkSKQDDMLFFV--KQFTiSGFkip-----snDVEVYRsn-ssNLPSL------LSLDV 179
EKC43130       6 SFWTDIFTKYFIdPSKLPDDq----RDDMLFYV-RKTHNpKNKsft----frpEIEVYRrd-skSLPAL------EDKTI 69 
EFJ47588      98 DWALSLQLNLVVQ-AKYILTVVQCRqetlaavaqghatsghyNPSNQQRDQLNTVVaqRRVYASPMAADVNLeeakSGQP 176
KRH52131     112 DWRRSFYLNLIAH-TSFSVTVAICShqdl---------lnhrAGEDTPLSPIYKVV--KTVYASPSRVNFQLds-kKEVE 178
XP_004238070 111 DWRRSFYLNLIAQ-TSFSVTVAICSqqvl---------qnyqTGKDRPLSPIYKVV--KTVYASPSRINFHLds-rKEVE 177
ANM58640     112 DWRKSFYLNMIAH-TSFTVTVAICSneal---------ktyqGSKDTKLSPIYKVV--KTVYASPSRVNFHLds-kKEVE 178
XP_002320676 112 DWRRSFYLNLIAH-TSYTVTVAICSqqvl---------rnhqAGQDTQLSPIYKVV--KTVYASPSRVYFHLds-kKEVE 178
XP_003573754 129 DWERSFYLNLVAH-TSYTVTVAICSigdl----------rnrAEKSKRLPPVYKVS--KTVYASPTRVNFRLdr-rKAVE 194
XP_009387109  73 DWRRSIYLNLIAH-TSYTVTVAICSkqdl---------eqrqSGQDISLSPIYKVV--KTVYASPSRVDFQLdh-kKAAE 139
XP_004994312  77 NWKETVCLNTLMQaVSFELTTALCK-----------------ETEARTLRPVQSSA--KEVYASPSYRSMDV----KGSG 133
XP_009026491 180 NWEETVYLNLILHhFQYHVTCAVCT-----------------RTGRNELQVLKKFT--QVVYPSPSYRGAEV----KGTS 236
EKC43130      70 DWEETVYMNIISHqLVYTATCAVCT-----------------RTSEHHLQILRKFS--QRVYPSPSKRRMDD----KGTE 126
EFJ47588     177 LKACYPDVCFAVDNFEDAFQDVILSRsDDCYCVMLHVHSSTDGSteipqlstvpteegansvnqsattfstpaaaqlpld 256
KRH52131     179 TTPAYPDICFAIDDFDSTFDAVVLTEkDHCYCVVLNAHDGAAFPsekvsndcstsdss--------------slqvhtis 244
XP_004238070 178 TTSAYPEICFAVDDFDSTFDAVVLTDvDHCYCVLLNAHDGAAFPrerirqdcspadt----------------sssdtss 241
ANM58640     179 TTPAYPEICFAVDDFDSTFDAVVLTDkDHCYCVLLNSHDGAAFPsatvkdssdsn--------------------tnadp 238
XP_002320676 179 TTPAYPDICFAVDDFDSTFDAVVLTEsDHCYCVLLNAHDGAAFPsdkelqdgssssnf--------------cqkndtsp 244
XP_003573754 195 TVPAYPNICFSVDDFDDPFDAVVLSDpEHCYCVILNAHDGAAFPeetkskndssniq----------------cgansgs 258
XP_009387109 140 TLPAYPNICFSVDDFDDTFDAVVLSErNHCYCVLLNAHGGPAFPtdedlpecnssrp----------------vnvhkdv 203
XP_004994312 134 DVITYPDLFFTVDDFDAFFEKYKVHP-SQTFTLELTA--RIGDF------------------------------------ 174
XP_009026491 237 EEITYPYIYFTIDNYEEAFSDLIMRD-SELLCVELVAKDQRDKF------------------------------------ 279
EKC43130     127 EELTYPNIYFTVDNFEEAFGDIVVRD-GELVSVELTASDRHGRA------------------------------------ 169
EFJ47588     257 icpverRAVLFSAYVTR-----------EQIagylasRVAETPK-----PSILNRLLARQRPed---------------- 304
KRH52131     245 akkkdtKLTLFSGFVSY-----------QMV------RDAYDAG-----RSRFGSLLSVVHS------------------ 284
XP_004238070 242 gkaptsKITLFSGFVSY-----------QMV------RDAYDAG-----RSGFGSLLSL-HS------------------ 280
ANM58640     239 rtvkdpKVTLFSGFVSY-----------QMV------REAYEGG-----RNRFGSLLSLGHI------------------ 278
XP_002320676 245 gkeknsKLTLFSGFVSY-----------QMV------REAYDAG-----KSRFGSLLG--QS------------------ 282
XP_003573754 259 nqvnppKRTLFSGYVSY-----------QNV------REAYDAG-----KSKFGSFLSLGQD------------------ 298
XP_009387109 204 eeakpsKLTLFSGFVSY-----------QMV------REAYDAG-----KSRFGSLLSMGHG------------------ 243
XP_004994312 175 ------ETILFTGSIAHstaspsnglvaEYM------SHARDRRkg-gaYSWISRN------------------------ 217
XP_009026491 280 ------KCVLFQGSVKY-----------PDL------RKGYDDKrssqnKSLYHKLSSSFRWlsnnsipcnssnktsmds 336
EKC43130     170 ------QGVIFLGAVRY-----------EVL------KKVYDARls-ltSKMMQTM--SLGMik---------------- 207
EFJ47588     305 ----------vKPRREKVVMIGPGS-VGRAEVL 326
KRH52131     285 -----------SGKTDRIYMKGPGG-RGEVEVA 305
XP_004238070 281 -----------VGKTDRIYMKGPGG-RGEVEVA 301
ANM58640     279 -----------TGKADRLYMRGPGG-RGEVEVA 299
XP_002320676 283 -----------PGKTDRLYMKGPGG-RGEVEVA 303
XP_003573754 299 -----------NTKPDKLFMRGPEG-RGEVEVA 319
XP_009387109 244 -----------HTKTDKIYMRGPGG-RGEVEVA 264
XP_004994312 218 -----------QDDLVFFNIKAPTGaAGYVEMA 239
XP_009026491 337 pdddddgegvaYQRVEFLKMRGPDG-KGITEIG 368
EKC43130     208 ----------qNKRVEFVRMRGPKS-KGHAEIA 229
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