5Y5A


Conserved Protein Domain Family
EST1_DNA_bind

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pfam10373: EST1_DNA_bind 
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Est1 DNA/RNA binding domain
Est1 is a protein which recruits or activates telomerase at the site of polymerization. This is the DNA/RNA binding domain of EST1.
Statistics
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PSSM-Id: 431239
Aligned: 50 rows
Threshold Bit Score: 95.5574
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y5A_A        220 PLRYLDIASTIVPSVGETFLQRGICYTHTKNFGNAAYQFVRSSLSRLPS-DAGIPNFTNLLGDPNGSLFKKLLNslddlk 298  Kluyveromyces...
XP_002493917  230 CLECLNLAILLLPSQGDPHNHIGLIERLRRNDFNIIYNFARSTMTRIHS-PNGFMNLILHLSSEMLLNTVSRAIlepekc 308 
Q6FU90        234 SKEYFDLASLLLPSSGETYLQRGMVYIQTDNLGTAVQEFIKGSLAKSPC-PAALSNFKTIILENDSTLHLRLDKlildvh 312  [Candida] gla...
EDO14661      222 SIRYFDMASLILPSVGETYLQKGMILISTENYGIASYEFIRSILSRIPN-LAGFSNLTKLLCDDKSSLRKRFESilldth 300 
CAR26928      226 SFRYLDLASLILPSIGEAHLQKGMINIQTDNLGNAIYEFTRSALSRIPS-PAGLTNFATIICEKDSNLRQRFDSvlketh 304 
XP_002554554  220 SMRYFNLATLVLPSVGEPYLQEGLIYVQARNFGFSTYSFARSALSRLPS-AAGLPNFLSSVCDPNSKIFTQVMIafqdif 298 
ABN64722      247 AIQFYKLCIVLIPALNEPYNHIGMICNTLNKQFEACIWFLRSTLTRIGNfQVGMNNFKSIIRKKPFVAKLNRINsdrfdg 326 
Q6BIA6        250 ALNFYKFCILLLPALNEPYNHIGMIYNLMDSKYDACYWFLRSQFTRLPDyKLGLTNLNTILRKDWFINHLISFNnpnkk- 328  Debaryomyces ...
EER30368      226 AIQYYNLCIMLIPALSEPYNQIGVIYNSVDDKFNAIYWFLRSHFSRLSEhQLGFANMSAILKKHWFTTALVDIVngns-- 303 
EDK40214      253 SMNFYKLCIMLLPTLHEPYNHIGMIHNIVGNKVEACYWFLRSRFTRIPNyDLGLKNLESIMVKSWFQDQLGDAFkskw-- 330 
5Y5A_A        299 vq--etikkriINMEIMEFYILPLIGSHIFPQTW--------------KNNRHSdrLKHFQTLLFDKIEIRYIkn----i 358  Kluyveromyces...
XP_002493917  309 ------rstvdSKLVKCNNYFIAIFGFHFLPQRWnd----------sqNMKFTDvsWKNIENDYRKSIATLDIhrpa-hv 371 
Q6FU90        313 sq--dlkgtkiVNREIIELYFLAIFGSYFAPDVWtnp--------kkpGFLRNGlaVKTLELTLYEKIASRYIkn----i 378  [Candida] gla...
EDO14661      301 nk--dilstriVDKEITEYYFLALFSNKFTKCIQkdipq-----ntddTLLDGRlkLNHIELALYERISTKYMkn----i 369 
CAR26928      305 lq--emegtkiINREIIEFYFLALFGAHFAPNAWlnpn------dkrcLLDGMG--TDHLKEVMLHRIRTRYLkn----v 370 
XP_002554554  299 k---qerdgrvVNREIIEIYFLVLFCANFAPALWsge---------tgKCLLSGarLQHIREQYCQKTATRYAkn----l 362 
ABN64722      327 grskteptmedDLNTMLACRVLYLYDPEEHQVDYktikk-----ttfsKLEDTL--SRHLKSSFSKLLSEGKDgs----- 394 
Q6BIA6        329 ------nkisvSKIDELNITLICLICYYYVPEYYhqsnntitknfkhsKIEGDF--FKKLFESFDKYIRRYEEed----l 396  Debaryomyces ...
EER30368      304 -------errfSNANVMNVFLVCLLGYIYCPERYkn----------gpNIVKKIp-FSKIETDLFKMISSDFDe------ 359 
EDK40214      331 --------qggDLHLTSQIVLLNLIGYHYFPQRYrhgel-----lygnETYDNVe-REYLSFEFSQSHFQQLMstsseyi 396 
5Y5A_A        359 sMIFQDLILLIGSFHmyqMINGVSsnirsi-----------qsetkFLEFIFKFFTHLIDKVIMKEFK-NCEMFQYLAMA 426  Kluyveromyces...
XP_002493917  372 kILWKQAIILISGYTilsNAKFNHewidrs----------enlleaYLQFVFHFIDEILTICTSGYSI----NTGLLPLV 437 
Q6FU90        379 eTIYNDLIIGIGGFN---LLQLFGnmgpdsrvkilksntltrnqlsYLSFVFTYITRIITDVIKEAWNgNHEVYLYLAML 455  [Candida] gla...
EDO14661      370 hTIFVSLLTVIGGYEiisLNNTNSndqlrikkis--ldeisekqlaYLKFAFDLISHIFNNVIAKGWEnNLEKYEYLAMV 447 
CAR26928      371 eTIFHSLVTVIGGFDlllIIRNGPkktpfdiksin-lkdldetclsYLKFAFDFITQVFNTVIKDCWQkNLENYQYLAMV 449 
XP_002554554  363 pLILQNEILLIAGFD---LLKTYNsankdeka-------tqkvknsFLGFSFDLISHFIDNVVVKEIE-NQQEWVYLAFV 431 
ABN64722      395 nFFLNQLVFLISI---------------------------------YYLFTYRYIDQFCTHLLDVELN-EISATNSLQCF 440 
Q6BIA6        397 nLYVKQLVVLMSFNK---LLERGSdkli---------------seqFIKFTFRYINKLLESCVSMEFD-YQNKRVVLIIL 457  Debaryomyces ...
EER30368      360 qVVLKHLVVMFGIVR---LTREDEqr------------------dkLLRFAFRYVEKVLVYLKTGDGL--MVLRFILNLL 416 
EDK40214      397 nHYVHSLSLLIMFSE---LLNENNnq-------------------kLFRLTKLYISGFLALVESIDLK-TEGFEGSLVFL 453 
5Y5A_A        427 RIMMCWIKSHKNVLkfahrSTSFCQSMVNLTNELLSs-------------nDLSISFEHLHRPTRDYFYEEDIMLKEFGP 493  Kluyveromyces...
XP_002493917  438 RLFLCWANQGGLPLnyllaNSSTFDNLVHICEVASL---------------LVNKDELCISKPQRQYYFYEDVDLKEFVP 502 
Q6FU90        456 RIIGCWIFANESVLefaksNVAFCQAYADLLNDFLAs-------------gLVSYGPDNSVKPKRSYLFEEDIQLRELGF 522  [Candida] gla...
EDO14661      448 RIVICWIKSNKSVIqyshrNRKFCDSFVNLLNNFLSs-------------kKFTEMTIPDVRPGRAYFFQEDIFLKEFSP 514 
CAR26928      450 RIVECWIKSNRAVLqfshrDEGFCKSLLQLLNDIGKs-------------kLVKVSPTANHRPKRKYFFPEDVDFKEFSC 516 
XP_002554554  432 RVVNCWLMSNKAALqfahrDVRFCDAMMRLMNSVLKs-------------pTLTRPPELNHRPRRPYFFEEDVSLRDFKS 498 
ABN64722      441 RLILNWIKENKRAYrslqdKHRTMSKIVQVSNKFLE-----------------DNSLNIPDKV---HYFQEDLMFKDFIV 500 
Q6BIA6        458 RLLSNWFKENKVILrnfqaRKSLMVNIVTLLNGMTSdiygndslsqdinreKIIHLIKSNSRPVRDYYFKEDVYFRDFLI 537  Debaryomyces ...
EER30368      417 RENAPWLQVFTs-------RRNCVVYLTAVLKRFAS---------------------DSTTRPTRMFFFEEDVNFRDCSL 468 
EDK40214      454 RLALAYIKENKPFAkyffrDAAMVVSLCSPFNEILSkc------------dWIHESVRTNSKPTRSYYYTEDVVFKDFSP 521 
5Y5A_A        494 TKFTL 498  Kluyveromyces lactis NRRL Y-1140
XP_002493917  503 IGCRF 507 
Q6FU90        523 IGDEL 527  [Candida] glabrata
EDO14661      515 IKYAL 519 
CAR26928      517 VKYAL 521 
XP_002554554  499 VKFTL 503 
ABN64722      501 IRNQF 505 
Q6BIA6        538 IKFQL 542  Debaryomyces hansenii
EER30368      469 IKYQF 473 
EDK40214      522 IKYQF 526 
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