Conserved Protein Domain Family
HMG-box_SoxC_SOX12
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cd22038: HMG-box_SoxC_SOX12 
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 12 (SOX12) and similar proteins
SOX-12, also called SOX-22, is a transcription factor essential for embryonic development and cell fate determination. It binds to the sequence 5'-AACAAT-3'. SOX-12 belongs to the group C of SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438847
Aligned: 3 rows
Threshold Bit Score: 185.266
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure evidence that Mus musculus SOX-4 binds DNA
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ## ## ##   #  #   #      ###  ##  #  ##                 #           
O15370        29 EPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYK 108 human
NP_001025449  42 DPNWCKTPTGHIKRPMNAFMVWSQIERRKIMEQWPDMHNAEISKRLGKRWKLLPDYEKIPFIKEAERLRLKHMADYPDYK 121 zebrafish
XP_006010601  41 EPGWCKTPSGHIKRPMNAFMVWSQIERRKIMEQWPDMHNAEISKRLGRRWKLLQDMEKIPFIKEAERLRLKHMADYPDYK 120 coelacanth

Feature 1        # ###   
O15370       109 YRPRKKSK 116 human
NP_001025449 122 YRPRKKSK 129 zebrafish
XP_006010601 121 YKPRKKGK 128 coelacanth

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