Conserved Protein Domain Family
7tmA_KiSS1R
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cd15095: 7tmA_KiSS1R 
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.
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Statistics
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PSSM-Id: 320223
Aligned: 19 rows
Threshold Bit Score: 386.638
Created: 15-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              #  ##            ######
Q969F8     43 WLVPLFFAALMLLGLVGNSLVIYVICRHKPMrt-vTNFYIANLAATDVTFLLCCVPFTALLYpl-pgWVLGdfmCKFVNY 120 human
ACD44939   50 WLVPLFFALIMLVGLIGNSLVIYVISKHRQMrt-aTNFYIANLASTDIMFLVCCVPFTATLYpl-psWVFGdfmCKFVAY 127 bullfrog
EMP23809   59 WLVPLFYALIMLLGLVGNSLVIYVVSKHRQMrt-aTNFYIANLATTDIIFLVCCVPFTATLYpl-psWIFGdfmCKLVNY 136 green seaturtle
Q6BD04     46 WLVPLFFSLIMLVGLVGNSLVIYVISKHRQMrt-aTNFYIANLAATDIIFLVCCVPFTATLYpl-pgWIFGnfmCKFVAF 123 Nile tilapia
XP_787561  35 WLVPTIFSVITLAGLAGNFVVIYTIYCHTKNrt-vTSYYILNLALTDIAFLLCCAPFTASVYat-ptWLFGrfmCKFVFY 112 purple urchin
XP_793011 305 WLVPLIFGIITVVGVSGNAIVCYVISRHVQMrt-aTNYYIMNLAITDIAFLVCCAPFTAAVYat-nnWIFGrfiCKFVMY 382 purple urchin
XP_796286  37 VIVPLIFVIIAVFAIAGNSLVIFIVLRYRKMrqsvTNFYILNVAVGDLVYMLACAPLTAALYad-yqWRFGnflCKFNAF 115 purple urchin
ACY92556   42 VVVPAVWGIFSLLGLIGNIFIVIVVFKYSHMrt-vTNYYIVNLACTDIAVLLLCVPFTSSVYafhtaWVFGdamCRFVAW 120 Saccoglossus kowal...
EEN69710   21 WVVPVLFALIGVVGVGANALVIYVSNKFNELkt-aTNRYIVGLAVVDLAFLFVCAPFTASLFat-tsWALGksmCKFIFY 98  Florida lancelet
EEN49849    3 WVVPLVFSIITLVGVTGNGLVIYVIARYGQMkt-vTNYYLLNLAVVDLSFLLCCVPFTAIIFat-ndWMFGsfmCKFVFY 80  Florida lancelet

Feature 1      ##  #                                            # #####                       
Q969F8    121 IQQVSVQATCATLTAMSVDRWYVTVFPlrALHRRtPRLALAVSLSIWVGSAAVSAPVLAlhrl--------spgpRAYCS 192 human
ACD44939  128 LQQVTVQATCITLTAMSADRCYATLYPlrSLRHRtPRVAMIVSMCIWIGSLLLSTPIIPyqkiqk----gywygpRTYCI 203 bullfrog
EMP23809  137 LQQVTAQATCITLTAMSMDRCYATLYPlqSLRYRtPRVAMGVSVAIWISSFLLSLPIAMyhrtev----gywyglRTYCI 212 green seaturtle
Q6BD04    124 LQQVTVQATCITLTAMSGDRCYVTVYPlkSLRHRtPKVAMIVSICIWIGSFVLSTPILMyqriee----gywygpRQYCM 199 Nile tilapia
XP_787561 113 MMQVSAQSTCITLTAMSVDRYQAIVYPlkSLRNRtPQIALVVSVGIWTCSALLAIPVAVyfdavq-----ntdgqVTRCE 187 purple urchin
XP_793011 383 MMQVTAQATCMTLTAMSIDRYQAIMRPlrSLGTRtQSGVLVVSACIWGALIAIPIAVYFdvkq---------fefGPVCI 453 purple urchin
XP_796286 116 LQHVTVQATCATLTVMTVDRYYVITNPftSRQTRtILRAGVICCIVWIVSGLMHVPAALiygttkpgehnyynepVIYCT 195 purple urchin
ACY92556  121 TQLASWQATCLTLTVISADRYYAIVYPirSIKYRtPRAAVLINISIWIFSYTITTPTLYlyrvev----yafdrdHAFCI 196 Saccoglossus kowal...
EEN69710   99 FMQVTVQAMCVTRCALTLDRYFAVVHPisSINYRsPRFAVTVCALIWIVALLMSAPLAAnldlhq----tewhgtQTYCM 174 Florida lancelet
EEN49849   81 FMQVTFTATGLTLAALSLDRYYAIIHPigSMYYRtPRTAFLVNAVVWAAAFVLASPVAVayqqwe----gnfqgpRTYCT 156 Florida lancelet

Feature 1                #  ### ### ##                                                        
Q969F8    193 EAFpsr---alERAFALYNLLALYLLPLLATCACYAAMLRHLGrvavrpa----------padsalQGQVLAERAGAVRA 259 human
ACD44939  204 EQFptd---tmKKACILYQFLAVYLLPLLTICLCYSLMLKRVGrpvvep------------mdnnyQVQLLSERTIAMRS 268 bullfrog
EMP23809  213 EAFask---sqERSIILYTFLAIYLLPLLTICLCYSVMLKRVGrpivep------------idhnyQVQHLSERSVATKA 277 green seaturtle
Q6BD04    200 ERFpsk---thERAFILYQFIAAYLLPVLTISFCYTLMVKRVGqptvep------------vdnnyQVNLLSERTISIRS 264 Nile tilapia
XP_787561 188 EVWpnk---mmFPGYAIYTFLLVYAIPLSIISVCYTIVLLRLWkqiq---------------pceeTRSSSQTRFLNQKR 249 purple urchin
XP_793011 454 EDWpnk--qymYPAYGLFTVIVLYVIPLFIIVVCYVSMLRTLWrtslp-------------geeeaCQSQNHRRAHKQKR 518 purple urchin
XP_796286 196 HTHtsn---rfIKFYSIYVIGVTYVIPLAIISVCYGLILAHLWklskggitatsgkaanrkgkaevLSEGSSVQTATKKW 272 purple urchin
ACY92556  197 EYFasdskanfNTVYVTVYALLSYFLPLVVIFVCYMLMIVRLWrts-----------------gptEDAIMSEQAVRQKK 259 Saccoglossus kowal...
EEN69710  175 ERWdsh---agQITYWITVVLLTYVLPLAIGIRSCIAVVEKLWgrna---------------vdpnIGPQIRNRILIKRR 236 Florida lancelet
EEN49849  157 DHWsnq---nwRKAYWVIMVVLCFVIPLAVCTFTSAHVFHRLWkksasq-----------plvtsnQHRALMRKRKVGER 222 Florida lancelet

Feature 1                     #  ## ##  #               ## ###  #  ##                     
Q969F8    260 KVSRLVAAVVLLFAACWGPIQLFLVLQalgpag-swhprsYAAYALKTWAHCMSYSNSALNPLLYAFLGshFRQAF 334 human
ACD44939  269 KISKMVIVIVLLFTICWGPIQLFSLFQgfypg----fqanYATYKIKTWANCMSYANSSINPIVYGFMGasFRKSF 340 bullfrog
EMP23809  278 KVSKMVVVIVVLFTVCWGPIQLYLLFQgfyds----fqanYETYKIKTWANCMSYANSSINPIVYAFMGdsFRKSF 349 green seaturtle
Q6BD04    265 KVSKMVVVIVLLFAICWGPIQIFVLFQsfypn----yqpnYATYKIKTWANCMSYANSSVNPIVYGFMGasFQKSF 336 Nile tilapia
XP_787561 250 RITRMVLAVIIAFAVCWLPLHIINLWQrldkn----fpknELTLALQTTAYCMAYANSCVNPFVYAFVGgrFRERV 321 purple urchin
XP_793011 519 RVTLMVLSVVIVFAACWFPVYVVNLWFrfdpn----fpktNFMYGVKVFAHLLTYANSCINPFVYSFMGrnFQRYF 590 purple urchin
XP_796286 273 KTTRIVLIVVMLFAICWAPIHAINLWNdvdpn---ypheaKYIYAFRMFCLILAYSNSCVNPVVYALAGnsFQVYF 345 purple urchin
ACY92556  260 KITRMVLVVVILYAVCHLPNHVLNLLFrwnyevfadpdnkMLLKVVRILAHTLVYFNSIINPIVYNVLGdnFRKSL 335 Saccoglossus kowalevskii
EEN69710  237 KVCLMVITMVVIFAICWLPTQVLLLWQedf-------pftLVTFSWKIAALILTYLQSAISPIVYIAFGhtFRRKL 305 Florida lancelet
EEN49849  223 TVCRMVVAVVVIFTICWAPNHIINLWVllddd----fpetWVMFGVKVAALCLSYANSSINPIIYAFMGenFRKRF 294 Florida lancelet

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